LONP2 (NM_001300948) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	LONP; LONPL; PLON; PSLON
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001300948, the custom clone sequence may differ by one or more nucleotides ATGTCATCAGTGAGCCCCATCCAGATCCCCAGTCGCCTCCCGCTGCTGCTCACCCACGAGGGCGTCCTGC TGCCCGGCTCCACCATGCGCACCAGCGTGGACTCGGCCCGCAACCTGCAGCTGGTGCGGAGCCGCCTTCT GAAGGGCACGTCGCTGCAAAGCACCATCCTGGGCGTCATCCCCAACACGCCTGACCCCGCCAGCGACGCG CAGGACCTGCCGCCGCTGCACAGGATTGGCACAGCTGCACTGGCCGTTCAGGTTGTGGGCAGTAACTGGC CCAAGCCCCACTACACTCTGTTGATTACAGGCCTATGCCGTTTCCAGATTGTACAGGTCTTAAAAGAGAA GCCATATCCCATTGCTGAAGTGGAGCAGTTGGACCGACTTGAGGAGTTTCCCAACACCTGTAAAATGAGG GAGGAGCTAGGAGAACTATCAGAGCAGTTTTACAAATATGCAGTACAAATTTTAGATGCTGTGAGCCTAG AGGAGCGGTTCAAGATGACTATACCACTGCTTGTCAGACAAATTGAAGGCCTGAAATTGCTTCAAAAAAC CAGAAAACCCAAGCAAGATGATGATAAGAGGGTTATAGCAATACGCCCTATTAGGAGAATTACACATATC TCAGGTACTTTAGAAGATGAAGATGAAGATGAAGATAATGATGACATTGTCATGCTAGAGAAAAAAATAC GAACATCTAGTATGCCAGAGCAGGCCCATAAAGTCTGTGTCAAAGAGATAAAGAGACTCAAAAAAATGCC TCAGTCAATGCCAGAATATGCTCTGACTAGAAATTATTTGGAACTTATGGTAGAACTTCCTTGGAACAAA AGTACAACTGACCGCCTGGACATTAGGGCAGCCCGGATTCTTCTGGATAATGACCATTACGCCATGGAAA AATTGAAGAAAAGAGTACTGGAATACTTGGCTGTCAGACAGCTCAAAAATAACCTGAAGGGCCCAATCCT ATGCTTTGTTGGCCCTCCTGGAGTTGGTAAAACAAGTGTGGGAAGATCAGTGGCCAAGACTCTAGGTCGA GAGTTCCACAGGATTGCACTTGGAGGAGTATGTGATCAGTCTGACATTCGAGGACACAGGCGCACCTATG TTGGCAGCATGCCTGGTCGCATCATCAACGGCTTGAAGACTGTGGGAGTGAACAACCCAGTGTTCCTATT AGATGAGGTTGACAAACTGGGAAAAAGTCTACAGGGTGATCCAGCAGCAGCTCTGCTTGAGGTGTTGGAT CCTGAACAAAACCATAACTTCACAGATCATTATCTAAATGTGGCCTTTGACCTTTCTCAAGTTCTTTTTA TAGCTACTGCCAACACCACTGCTACCATTCCAGCTGCCTTGTTGGACAGAATGGAGATCATTCAGGTTCC AGGTTATACACAGGAGGAGAAGATAGAGATTGCCCATAGGCACTTGATCCCCAAGCAGCTGGAACAACAT GGGCTGACTCCACAGCAGATTCAGATACCCCAGGTCACCACTCTTGACATCATCACCAGGTATACCAGAG AGGCAGGGGTTCGTTCTCTGGATAGAAAACTTGGGGCCATTTGCCGAGCTGTGGCCGTGAAGGTGGCAGA AGGACAGCATAAGGAAGCCAAGTTGGACCGTTCTGATGTGACTGAGAGAGAAGGTTGCAGAGAACACATC TTAGAAGATGAAAAACCTGAATCTATCAGTGACACTACTGACTTGGCTCTACCACCTGAAATGCCGATTT TGATTGATTTCCATGCTCTGAAAGACATCCTTGGGCCCCCGATGTATGAAATGGAGGTATCTCAGCGTTT GAGTCAGCCAGGAGTAGCAATAGGTTTGGCTTGGACTCCCTTAGGTGGAGAAATCATGTTCGTGGAGGCG AGTCGAATGGATGGCGAGGGCCAGTTAACTCTGACCGGCCAGCTCGGGGACGTGATGAAGGAGTCCGCCC ACCTCGCTATCAGCTGGCTCCGCAGCAACGCAAAGAAGTACCAGCTGACCAATGCTTTTGGAAGTTTTGA TCTTCTTGACAACACAGACATCCATCTGCACTTCCCAGCTGGAGCTGTCACAAAAGATGGACCATCTGCT GGAGTTACCATAGTAACCTGTCTCGCCTCACTTTTTAGTGGGCGGCTGGTACGTTCAGATGTAGCCATGA CTGGAGAAATTACACTGAGAGGTCTTGTTCTTCCAGTGGGTGGAATTAAAGACAAAGTGCTGGCGGCACA CAGAGCGGGACTGAAGCAAGTCATTATTCCTCGGAGAAATGAAAAAGACCTTGAGGGAATCCCAGGCAAC GTACGACAGGATTTAAGTTTTGTCACAGCAAGCTGCCTGGATGAGGTTCTTAATGCAGCTTTTGATGGTG GCTTTACTGTCAAGACCAGACCTGGTCTGTTAAATAGCAAACTGTAG
Restriction Sites	SgfI-MluI
ACCN	NM_001300948
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001300948.1, NP_001287877.1
RefSeq Size	4826 bp
RefSeq ORF	2427 bp
Locus ID	83752
UniProt ID	Q86WA8
Protein Families	Druggable Genome, Protease
Gene Summary	In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017] Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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