SRPK2 (NM_001278273) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	SFRSK2
Vector	pCMV6 series
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for NM_001278273, the custom clone sequence may differ by one or more nucleotides ATGTCAGTTAACTCTGAGAAGTCGTCCTCTTCAGAAAGGCCGGAGCCTCAACAGAAAGCTCCTTTAGTTC CTCCTCCTCCACCGCCACCACCACCACCACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGA GGAGATCCTGGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTACTGCAAAGGTGGATATCATCCA GTGAAAATTGGAGACCTCTTCAATGGCCGGTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTCTA CTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAAAGTTGTAAAAAGTGCCCAGCA TTATACGGAGACAGCCTTGGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCCA AACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAAGATTTCAGGCATGAATGGGATACATGTCTGCA TGGTCTTCGAAGTACTTGGCCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCAAGGCCTCCCAGT ACGTTGTGTGAAGAGTATCATTCGACAGGTCCTTCAAGGGTTAGATTACTTACACAGTAAGTGCAAGATC ATTCATACTGACATAAAGCCGGAAAATATCTTGATGTGTGTGGATGATGCATATGTGAGAAGAATGGCAG CTGAGGCCACTGAGTGGCAGAAAGCAGGTGCTCCTCCTCCTTCAGGGTCTGCAGTGAGTACGGCTCCACA GCAGAAACCTATAGGAAAAATATCTAAAAACAAAAAGAAAAAACTGAAAAAGAAACAGAAGAGGCAGGCT GAGTTATTGGAGAAGCGCCTGCAGGAGATAGAAGAATTGGAGCGAGAAGCTGAAAGGAAAATAATAGAAG AAAACATCACCTCAGCTGCACCTTCCAATGACCAGGATGGCGAATACTGCCCAGAGGTGAAACTAAAAAC AACAGGATTAGAGGAGGCGGCTGAGGCAGAGACTGCAAAGGACAATGGTGAAGCTGAGGACCAGGAAGAG AAAGAAGATGCTGAGAAAGAAAACATTGAAAAAGATGAAGATGATGTAGATCAGGAACTTGCGAACATAG ACCCTACGTGGATAGAATCACCTAAAACCAATGGCCATATTGAGAATGGCCCATTCTCACTGGAGCAGCA ACTGGACGATGAAGATGATGATGAAGAAGACTGCCCAAATCCTGAGGAATATAATCTTGATGAGCCAAAT GCAGAAAGTGATTACACATATAGCAGCTCCTATGAACAATTCAATGGTGAATTGCCAAATGGACGACATA AAATTCCCGAGTCACAGTTCCCAGAGTTTTCCACCTCGTTGTTCTCTGGATCCTTAGAACCTGTGGCCTG CGGCTCTGTGCTTTCTGAGGGATCACCACTTACTGAGCAAGAGGAGAGCAGTCCATCCCATGACAGAAGC AGAACGGTTTCAGCCTCCAGTACTGGGGATTTGCCAAAAGCAAAAACCCGGGCAGCTGACTTGTTGGTGA ATCCCCTGGATCCGCGGAATGCAGATAAAATTAGAGTAAAAATTGCTGACCTGGGAAATGCTTGTTGGGT GCATAAACACTTCACGGAAGACATCCAGACGCGTCAGTACCGCTCCATAGAGGTTTTAATAGGAGCGGGG TACAGCACCCCTGCGGACATCTGGAGCACGGCGTGTATGGCATTTGAGCTGGCAACGGGAGATTATTTGT TTGAACCACATTCTGGGGAAGACTATTCCAGAGACGAAGACCACATAGCCCACATCATAGAGCTGCTAGG CAGTATTCCAAGGCACTTTGCTCTATCTGGAAAATATTCTCGGGAATTCTTCAATCGCAGAGGAGAACTG CGACACATCACCAAGCTGAAGCCCTGGAGCCTCTTTGATGTACTTGTGGAAAAGTATGGCTGGCCCCATG AAGATGCTGCACAGTTTACAGATTTCCTGATCCCGATGTTAGAAATGGTTCCAGAAAAACGAGCCTCAGC TGGCGAATGCCTTCGGCATCCTTGGTTGAATTCTTAG
Restriction Sites	SgfI-RsrII
ACCN	NM_001278273
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001278273.1, NP_001265202.1
RefSeq Size	3727 bp
RefSeq ORF	2067 bp
Locus ID	6733
UniProt ID	P78362
Protein Families	Druggable Genome, Protein Kinase
Gene Summary	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

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