CLPB (NM_001258393) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ANKCLB; HSP78; MEGCANN; MGCA7; SKD3
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332688 representing NM_001258393. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGCTGGGGTCCCTGGTGTTGAGGAGAAAAGCACTGGCGCCACGGCTACTCCTCCGGCTGCTCAGGTCC CCAACGCTCCGGGGCCATGGAGGTGCTTCCGGCCGGAATGTGACTACTGGGAGTCTCGGGGAGCCGCAG TGGCTGAGGGTAGCCACCGGGGGGCGCCCTGGAACATCGCCGGCCTTGTTCTCCGGACGTGGGGCAGCC ACCGGGGGGCGCCAGGGAGGACGCTTCGATACCAAATGCCTCGCGGCTGCCACTTGGGGACGCCTTCCT GGTCCCGAAGAAACACTCCCAGGACAGGACAGCTGGAACGGGGTCCCCAGCAGGGCCGGACTGGGCATG TGCGCCCTGGCCGCAGCGCTGGTGGTTCATTGCTACAGCAAGAGTCCGTCCAACAAGGATGCAGCCCTG TTGGAAGCTGCCCGTGCCAACAATATGCAAGAAGTCAGCAGTGTGGTACAGGTCCTGCTTGCTGCTGGG GCTGATCCAAACCTTGGAGATGATTTCAGCAGTGTTTACAAGACTGCCAAGGAACAGGGAATCCATTCT TTGGAAGTCCTGATCACCCGAGAGGATGACTTCAACAACAGGCTGAACAACCGCGCCAGTTTCAAGGGC TGCACGGCCTTGCACTATGCTGTTCTTGCTGATGACTACCGCACTGTCAAGGAGCTGCTTGATGGAGGA GCCAACCCCCTGCAGAGGAATGAAATGGGACACACACCCTTGGATTATGCCCGAGAAGGGGAAGTGATG AAGCTTCTGAGGACTTCTGAAGCCAAGTACCAAGAGAAGCAGCGGAAGCGTGAGGCTGAGGAGCGGCGC CGCTTCCCCCTGGAGCAGCGACTAAAGGAGCACATCATTGGCCAGGAGAGCGCCATCGCCACAGTGGGT GCTGCGATCCGGAGGAAGGAGAATGGCTGGTACGATGAAGAACACCCTCTGGTCTTCCTCTTCTTGGGA TCATCTGGAATAGGAAAAACAGAGCTGGCCAAGCAGACAGCCAAATATATGCACAAAGATGCTAAAAAG GGCTTCATCAGGCTGGACATGTCCGAGTTCCAGGAGCGACACGAGGTGGCCAAGTTTATTGGGTCTCCA CCAGGCTACGTTGGCCATGAGGAGGGTGGCCAGCTGACCAAGAAGTTGAAGCAGTGCCCCAATGCTGTG GTGCTCTTTGATGAAGTAGACAAGGCCCATCCAGATGTGCTCACCATCATGCTGCAGCTGTTTGATGAG GGCCGGCTGACAGATGGAAAAGGGAAGACCATTGATTGCAAGGACGCCATCTTCATCATGACCTCCAAT GTGGCCAGCGACGAGATCGCACAGCACGCGCTGCAGCTGAGGCAGGAAGCTTTGGAGATGAGCCGTAAC CGTATTGCCGAAAACCTGGGGGATGTCCAGATAAGTGACAAGATCACCATCTCAAAGAACTTCAAGGAG AATGTGATTCGCCCTATCCTGAAAGCTCACTTCCGGAGGGATGAGTTTCTGGGACGGATCAATGAGATC GTCTACTTCCTCCCCTTCTGCCACTCGGAGCTCATCCAACTCGTCAACAAGGAACTAAACTTCTGGGCC AAGAGAGCCAAGCAAAGGCACAACATCACGCTGCTCTGGGACCGCGAGGTGGCAGATGTGCTGGTCGAC GGCTACAATGTGCACTATGGCGCCCGCTCCATCAAACATGAGGTAGAACGCCGTGTGGTGAACCAGCTG GCAGCAGCCTATGAGCAGGACCTGCTGCCAGGGGGCTGTACTTTGCGCATCACGGTGGAGGACTCAGAC AAGCAGCTACTCAAAAGCCCAGAACTGCCCTCACCCCAGGCTGAGAAGCGCCTCCCCAAGCTGCGTCTG GAGATCATCGACAAGGACAGCAAGACTCGCAGACTGGACATCCGGGCACCACTGCACCCTGAGAAGGTG TGCAACACCATCTAG
Restriction Sites	SgfI-MluI
ACCN	NM_001258393
Insert Size	1947 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001258393.1
RefSeq Size	3095 bp
RefSeq ORF	1947 bp
Locus ID	81570
UniProt ID	Q9H078
MW	72.3 kDa
Gene Summary	This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

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