DIP13B (APPL2) (NM_001251904) Human Untagged Clone

CAT#: SC332146

APPL2 (untagged) - Homo sapiens adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2), transcript variant 2



  "NM_001251904" in other vectors (2)

CNY 6,460.00


货期*
5周

规格
    • 10 ug

Product images

经常一起买 (4)
APPL2 mouse monoclonal antibody,clone OTI1H8
    • 100 ul

CNY 1,999.00
CNY 2,700.00


TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Synonyms DIP13B
Vector pCMV6-Entry
Sequence Data
>SC332146 representing NM_001251904.
Blue=Insert sequence Red=Cloning site Green=Tag(s)

ATGCCCGCCGTGGACAAGCTCCTGCTAGAGGAGGCGTTGCAGGACAGCCCCCAGACTCGCTCTTTACTG
AGCGTGTTTGAAGAAGATGCTGGCACCCTCACAGACTATACCAACCAGCTGCTCCAGGCAATGCAGCGC
GTCTATGGAGCCCAGAATGAGATGTGCCTGGCCACACAACAGCTTTCTAAGCAACTGCTGGCATATGAA
AAACAGAACTTTGCTCTTGGCAAAGGTGATGAAGAAGTAATTTCAACACTCCACTATTTTTCCAAAGTG
GTGGATGAGCTTAATCTTCTCCATACAGAGCTGGCTAAACAGTTGGCAGACACAATGGTTCTACCTATC
ATACAATTCCGAGAAAAGGATCTCACAGAAGTAAGCACTTTAAAGGATCTATTTGGACTCGCTAGCAAT
GATGTCTGTTTATTTTTAGAGCATGACCTCTCAATGGCAAAATACAGCAGGCTGCCTAAGAAAAAGGAG
AATGAGAAGGTGAAGACCGAAGTCGGAAAAGAGGTGGCCGCGGCCCGGCGGAAGCAGCACCTCTCCTCC
CTTCAGTACTACTGTGCCCTCAACGCGCTGCAGTACAGAAAGCAAATGGCCATGATGGAGCCCATGATA
GGCTTTGCCCATGGACAGATTAACTTTTTTAAGAAGGGAGCAGAGATGTTTTCCAAACGTATGGACAGC
TTTTTATCCTCCGTTGCAGACATGGTTCAAAGCATTCAGGTAGAACTGGAAGCCGAGGCGGAAAAGATG
CGGGTGTCCCAGCAAGAATTACTTTCTGTTGATGAATCTGTTTACACTCCAGACTCTGATGTGGCCGCA
CCACAGATCAACAGGAACCTCATCCAGAAGGCTGGTTACCTTAATCTTAGAAACAAAACAGGGCTGGTC
ACCACCACCTGGGAGAGGCTTTATTTCTTCACCCAAGGCGGGAATCTCATGTGTCAGCCCAGGGGAGCC
GTGGCTGGAGGTTTGATCCAGGACCTGGACAACTGCTCAGTGATGGCCGTGGATTGCGAAGACCGGCGC
TACTGCTTCCAGATCACCACGCCCAATGGAAAATCGGGAATAATCCTCCAGGCTGAGAGCAGAAAGGAA
AATGAAGAGTGGATATGTGCAATAAACAACATCTCCAGACAGATCTACCTGACCGACAACCCTGAGGCA
GTCGCGATCAAGTTGAATCAGACCGCTCTGCAAGCAGTGACTCCCATTACAAGTTTTGGAAAAAAACAA
GAAAGCTCATGCCCCAGCCAGAACCTGAAAAATTCAGAGATGGAAAATGAAAATGACAAGATTGTTCCC
AAAGCAACAGCCAGTCTACCTGAAGCAGAGGAGCTGATCGCGCCTGGAACGCCGATTCAATTCGATATT
GTGCTTCCTGCTACAGAATTCCTTGATCAGAACAGAGGGAGCAGGCGTACCAACCCTTTTGGTGAAACT
GAGGATGAATCATTTCCAGAAGCAGAAGATTCTCTTTTGCAGCAGATGTTTATAGTTCGGTTTTTGGGA
TCAATGGCAGTTAAAACAGACAGCACTACTGAAGTGATTTATGAAGCGATGAGACAAGTATTGGCTGCT
CGGGCTATTCATAACATCTTCCGCATGACAGAATCCCATCTGATGGTCACCAGTCAATCTTTGAGGTTG
ATAGATCCACAGACTCAAGTATCAAGGGCCAATTTTGAACTTACCAGTGTCACACAATTTGCTGCTCAT
CAAGAAAACAAGAGACTGGTTGGTTTTGTCATCCGTGTTCCTGAATCCACTGGAGAAGAATCTCTGAGT
ACATACATTTTTGAAAGCAACTCAGAAGGCGAAAAGATATGTTATGCTATTAATTTGGGAAAAGAAATT
ATTGAGGTTCAGAAGGATCCAGAAGCACTGGCTCAATTAATGCTGTCCATACCACTAACCAATGACGGA
AAATATGTACTGTTAAACGATCAACCAGATGACGATGATGGAAATCCAAACGAACATAGAGGCGCAGAA
TCCGAAGCATAA

Restriction Sites SgfI-MluI     
ACCN NM_001251904
Insert Size 2013 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_001251904.1
RefSeq Size 3307 bp
RefSeq ORF 2013 bp
Locus ID 55198
UniProt ID Q8NEU8
MW 75.2 kDa
Gene Summary The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Transcript Variant: This variant (2) has an additional in-frame segment in the coding region, compared to variant 1. The resulting isoform 2 is longer than isoform 1.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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