RON (MST1R) (NM_001244937) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CD136; CDw136; NPCA3; PTK8; RON; SEA
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC332104 representing NM_001244937. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGAGCTCCTCCCGCCGCTGCCTCAGTCCTTCCTGTTGCTGCTGCTGTTGCCTGCCAAGCCCGCGGCG GGCGAGGACTGGCAGTGCCCGCGCACCCCCTACGCGGCCTCTCGCGACTTTGACGTGAAGTACGTGGTG CCCAGCTTCTCCGCCGGAGGCCTGGTACAGGCCATGGTGACCTACGAGGGCGACAGAAATGAGAGTGCT GTGTTTGTAGCCATACGCAATCGCCTGCATGTGCTTGGGCCTGACCTGAAGTCTGTCCAGAGCCTGGCC ACGGGCCCTGCTGGAGACCCTGGCTGCCAGACGTGTGCAGCCTGTGGCCCAGGACCCCACGGCCCTCCC GGTGACACAGACACAAAGGTGCTGGTGCTGGATCCCGCGCTGCCTGCGCTGGTCAGTTGTGGCTCCAGC CTGCAGGGCCGCTGCTTCCTGCATGACCTAGAGCCCCAAGGGACAGCCGTGCATCTGGCAGCGCCAGCC TGCCTCTTCTCAGCCCACCATAACCGGCCCGATGACTGCCCCGACTGTGTGGCCAGCCCATTGGGCACC CGTGTAACTGTGGTTGAGCAAGGCCAGGCCTCCTATTTCTACGTGGCATCCTCACTGGACGCAGCCGTG GCTGCCAGCTTCAGCCCACGCTCAGTGTCTATCAGGCGTCTCAAGGCTGACGCCTCGGGATTCGCACCG GGCTTTGTGGCGTTGTCAGTGCTGCCCAAGCATCTTGTCTCCTACAGTATTGAATACGTGCACAGCTTC CACACGGGAGCCTTCGTATACTTCCTGACTGTACAGCCGGCCAGCGTGACAGATGATCCTAGTGCCCTG CACACACGCCTGGCACGGCTTAGCGCCACTGAGCCAGAGTTGGGTGACTATCGGGAGCTGGTCCTCGAC TGCAGATTTGCTCCAAAACGCAGGCGCCGGGGGGCCCCAGAAGGCGGACAGCCCTACCCTGTGCTGCGG GTGGCCCACTCCGCTCCAGTGGGTGCCCAACTTGCCACTGAGCTGAGCATCGCCGAGGGCCAGGAAGTA CTATTTGGGGTCTTTGTGACTGGCAAGGATGGTGGTCCTGGCGTGGGCCCCAACTCTGTCGTCTGTGCC TTCCCCATTGACCTGCTGGACACACTAATTGATGAGGGTGTGGAGCGCTGTTGTGAATCCCCAGTCCAT CCAGGCCTCCGGCGAGGCCTCGACTTCTTCCAGTCGCCCAGTTTTTGCCCCAACCCGCCTGGCCTGGAA GCCCTCAGCCCCAACACCAGCTGCCGCCACTTCCCTCTGCTGGTCAGTAGCAGCTTCTCACGTGTGGAC CTATTCAATGGGCTGTTGGGACCAGTACAGGTCACTGCATTGTATGTGACACGCCTTGACAACGTCACA GTGGCACACATGGGCACAATGGATGGGCGTATCCTGCAGGTGGAGCTGGTCAGGTCACTAAACTACTTG CTGTATGTGTCCAACTTCTCACTGGGTGACAGTGGGCAGCCCGTGCAGCGGGATGTCAGTCGTCTTGGG GACCACCTACTCTTTGCCTCTGGGGACCAGGTTTTCCAGGTACCTATCCAAGGCCCTGGCTGCCGCCAC TTCCTGACCTGTGGGCGTTGCCTAAGGGCATGGCATTTCATGGGCTGTGGCTGGTGTGGGAACATGTGC GGCCAGCAGAAGGAGTGTCCTGGCTCCTGGCAACAGGACCACTGCCCACCTAAGCTTACTGAGTTCCAC CCCCACAGTGGACCTCTAAGGGGCAGTACAAGGCTGACCCTGTGTGGCTCCAACTTCTACCTTCACCCT TCTGGTCTGGTGCCTGAGGGAACCCATCAGGTCACTGTGGGCCAAAGTCCCTGCCGGCCACTGCCCAAG GACAGCTCAAAACTCAGACCAGTGCCCCGGAAAGACTTTGTAGAGGAGTTTGAGTGTGAACTGGAGCCC TTGGGCACCCAGGCAGTGGGGCCTACCAACGTCAGCCTCACCGTGACTAACATGCCACCGGGCAAGCAC TTCCGGGTAGACGGCACCTCCGTGCTGAGAGGCTTCTCTTTCATGGAGCCAGTGCTGATAGCAGTGCAA CCCCTCTTTGGCCCACGGGCAGGAGGCACCTGTCTCACTCTTGAAGGCCAGAGTCTGTCTGTAGGCACC AGCCGGGCTGTGCTGGTCAATGGGACTGAGTGTCTGCTAGCACGGGTCAGTGAGGGGCAGCTTTTATGT GCCACACCCCCTGGGGCCACGGTGGCCAGTGTCCCCCTTAGCCTGCAGGTGGGGGGTGCCCAGGTACCT GGTTCCTGGACCTTCCAGTACAGAGAAGACCCTGTCGTGCTAAGCATCAGCCCCAACTGTGGCTACATC AACTCCCACATCACCATCTGTGGCCAGCATCTAACTTCAGCATGGCACTTAGTGCTGTCATTCCATGAC GGGCTTAGGGCAGTGGAAAGCAGGTGTGAGAGGCAGCTTCCAGAGCAGCAGCTGTGCCGCCTTCCTGAA TATGTGGTCCGAGACCCCCAGGGATGGGTGGCAGGGAATCTGAGTGCCCGAGGGGATGGAGCTGCTGGC TTTACACTGCCTGGCTTTCGCTTCCTACCCCCACCCCATCCACCCAGTGCCAACCTAGTTCCACTGAAG CCTGAGGAGCATGCCATTAAGTTTGAGGTCTGCGTAGATGGTGAATGTCATATCCTGGGTAGAGTGGTG CGGCCAGGGCCAGATGGGGTCCCACAGAGCACGCTCCTTGGTATCCTGCTGCCTTTGCTGCTGCTTGTG GCTGCACTGGCGACTGCACTGGTCTTCAGCTACTGGTGGCGGAGGAAGCAGCTAGTTCTTCCTCCCAAC CTGAATGACCTGGCATCCCTGGACCAGACTGCTGGAGCCACACCCCTGCCTATTCTGTACTCGGGCTCT GACTACAGAAGTGGCCTTGCACTCCCTGCCATTGATGGTCTGGATTCCACCACTTGTGTCCATGGAGCA TCCTTCTCCGATAGTGAAGATGAATCCTGTGTGCCACTGCTGCGGAAAGAGTCCATCCAGCTAAGGGAC CTGGACTCTGCGCTCTTGGCTGAGGTCAAGGATGTGCTGATTCCCCATGAGCGGGTGGTCACCCACAGT GACCGAGTCATTGGCAAAGGCCACTTTGGAGTTGTCTACCACGGAGAATACATAGACCAGGCCCAGAAT CGAATCCAATGTGCCATCAAGTCACTAAGTCGCATCACAGAGATGCAGCAGGTGGAGGCCTTCCTGCGA GAGGGGCTGCTCATGCGTGGCCTGAACCACCCGAATGTGCTGGCTCTCATTGGTATCATGTTGCCACCT GAGGGCCTGCCCCATGTGCTGCTGCCCTATATGTGCCACGGTGACCTGCTCCAGTTCATCCGCTCACCT CAGCGGAACCCCACCGTGAAGGACCTCATCAGCTTTGGCCTGCAGGTAGCCCGCGGCATGGAGTACCTG GCAGAGCAGAAGTTTGTGCACAGGGACCTGGCTGCGCGGAACTGCATGCTGGACGAGTCATTCACAGTC AAGGTGGCTGACTTTGGTTTGGCCCGCGACATCCTGGACAGGGAGTACTATAGTGTTCAACAGCATCGC CACGCTCGCCTACCTGTGAAGTGGATGGCGCTGGAGAGCCTGCAGACCTATAGATTTACCACCAAGTCT GATGTGTGGTCATTTGGTGTGCTGCTGTGGGAACTGCTGACACGGGGTGCCCCACCATACCGCCACATT GACCCTTTTGACCTTACCCACTTCCTGGCCCAGGGTCGGCGCCTGCCCCAGCCTGAGTATTGCCCTGAT TCTCTGTACCAAGTGATGCAGCAATGCTGGGAGGCAGACCCAGCAGTGCGACCCACCTTCAGAGTACTA GTGGGGGAGGTGGAGCAGATAGTGTCTGCACTGCTTGGGGACCATTATGTGCAGCTGCCAGCAACCTAC ATGAACTTGGGCCCCAGCACCTCGCATGAGATGAATGTGCGTCCAGAACAGCCGCAGTTCTCACCCATG CCAGGGAATGTACGCCGGCCCCGGCCACTCTCAGAGCCTCCTCGGCCCACTTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001244937
Insert Size	4056 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001244937.1
RefSeq Size	4638 bp
RefSeq ORF	4056 bp
Locus ID	4486
UniProt ID	Q04912
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
MW	147.2 kDa
Gene Summary	This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016] Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as isoform delta-Ron) missing an internal segment compared to isoform 1.

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