SAFB (NM_001201340) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HAP; HET; SAB-B1; SAF-B; SAF-B1; SAFB1
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331412 representing NM_001201340. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGCGGAGACTCTGTCAGGCCTAGGTGATTCTGGAGCGGCGGGCGCGGCGGCTCTGAGCTCCGCCTCG TCAGAGACCGGGACGCGGCGCCTCAGCGACCTGCGAGTGATCGATCTGCGGGCGGAGCTGAGGAAACGG AATGTGGACTCGAGCGGCAACAAGAGCGTTTTGATGGAGCGGCTGAAGAAGGCAATTGAAGATGAAGGT GGTAATCCTGACGAAATTGAAATTACCTCCGAGGGAAACAAGAAAACATCAAAGAGGTCTAGCAAAGGG CGCAAACCAGAAGAAGAGGGTGTGGAAGATAACGGGCTGGAGGAAAACTCTGGGGATGGACAGATAGAG GACAAAGAAACTATAAACAATTTAGATACTTCATCATCTGACTTCACTATATTACAGGAAATTGAAGAG CCATCCCTGGAGCCAGAAAATGAGAAAATACTCGACATTTTGGGGGAAACTTGTAAATCTGAGCCAGTA AAAGAAGAAAGTTCCGAGCTGGAGCAGCCATTTGCACAGGACACAAGTAGCGTGGGGCCAGACAGAAAG CTTGCGGAGGAAGAGGACCTATTTGACAGCGCCCATCCGGAAGAGGGTGATTTAGATTTGGCCAGCGAG TCAACAGCACACGCTCAGTCGAGCAAGGCAGACAGCCTGTTAGCGGTAGTGAAAAGGGAGCCCGCGGAG CAGCCAGGCGATGGCGAGAGGACGGACTGTGAGCCTGTAGGGCTAGAGCCGGCAGTTGAGCAGAGTAGT GCGGCCTCCGAGCTCGCGGAGGCCTCTAGCGAGGAGCTCGCAGAAGCACCCACGGAAGCCCCAAGCCCA GAAGCCAGAGATAGCAAAGAAGACGGGAGGAAGTTTGATTTTGACGCTTGTAATGAAGTCCCTCCGGCT CCTAAAGAGTCCTCAACCAGTGAGGGCGCTGATCAGAAAATGAGTTCTCCCGAAGATGACTCGGATACA AAAAGGCTTTCCAAAGAGGAAAAGGGTCGCAGCAGTTGTGGTAGAAATTTCTGGGTTAGTGGACTCTCT TCTACAACCAGAGCTACAGATTTGAAGAATCTTTTCAGCAAATATGGGAAGGTGGTGGGCGCCAAGGTT GTGACAAATGCCCGGAGTCCTGGAGCTCGCTGTTACGGTTTTGTCACGATGTCCACAGCAGAAGAGGCC ACAAAATGCATTAACCACCTGCACAAGACGGAGCTCCACGGAAAGATGATCTCCGTGGAGAAAGCCAAA AATGAACCTGTGGGAAAGAAAACCTCTGACAAAAGAGACAGTGACGGGAAAAAGGAGAAGTCGAGCAAC AGTGACAGATCTACAAACCTTAAGAGGGATGATAAATGTGACAGAAAAGATGATGCTAAGAAGGGTGAC GACGGAAGTGGAGAAAAGAGTAAGGACCAAGATGATCAGAAACCTGGCCCCTCAGAGCGATCTCGAGCC ACAAAGTCAGGAAGTCGAGGGACCGAACGGACTGTAGTAATGGATAAATCCAAAGGGGTGCCTGTGATT AGTGTAAAAACGTCCGGGTCCAAAGAGAGAGCTTCCAAAAGCCAGGATCGCAAATCAGCCAGCAGAGAG AAGCGGTCCGTCGTGTCCTTTGATAAGGTCAAGGAGCCTCGGAAGTCAAGAGACTCAGAGTCCCATAGC AGGGTGCGTGAACGCAGTGAACGCGAACAACGCATGCAGGCGCAGTGGGAGCGCGAGGAGCGTGAGCGG CTGGAGATTGCCCGAGAGAGGCTGGCCTTCCAGCGCCAGCGGCTGGAGCGGGAGCGCATGGAGCGGGAA CGGCTGGAGCGCGAACGCATGCACGTGGAGCACGAGCGCAGGCGCGAGCAGGAGCGCATCCACCGTGAG CGCGAGGAGCTGAGGCGCCAGCAGGAACTGCGCTATGAGCAGGAGCGGCGGCCCGCGGTGCGGCGGCCC TACGACCTGGACCGGCGAGATGATGCCTATTGGCCGGAAGCCAAGCGGGCCGCCCTGGATGAGCGCTAC CATTCTGACTTTAACCGCCAGGACCGCTTCCACGACTTTGACCACAGGGACCGCGGCCGCTACCCCGAC CACTCGGTGGACAGGAGAGAAGGTTCAAGGTCAATGATGGGAGAACGAGAAGGACAGCATTACCCAGAA CGCCATGGAGGACCAGAGCGCCACGGCCGGGACTCCCGCGATGGCTGGGGGGGCTATGGCTCTGACAAG AGGATGAGCGAGGGCCGGGGGCTGCCTCCTCCCCCCAGGGGCAGACGTGACTGGGGGGACCATGGCCGA AGAGAGGATGACCGGTCATGGCAGGGCACGGCCGACGGGGGCATGATGGACAGGGATCACAAGAGGTGG CAAGGTGGCGAGAGAAGCATGTCCGGTCACTCCGGGCCTGGCCACATGATGAACCGAGGAGGAATGTCA GGGCGCGGCAGCTTTGCCCCAGGCGGGGCCTCCCGGGGCCACCCCATCCCACACGGTGGCATGCAGGGC GGGTTTGGAGGCCAGAGCCGGGGGAGCAGGCCCAGCGATGCCCGCTTCACTCGCCGCTACTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001201340
Insert Size	2547 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001201340.1
RefSeq Size	2914 bp
RefSeq ORF	2547 bp
Locus ID	6294
UniProt ID	Q15424
Protein Families	Druggable Genome, Transcription Factors
MW	95.2 kDa
Gene Summary	This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 4) is shorter compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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