VNN2 (NM_001242350) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	FOAP-4; GPI-80
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC329931 representing NM_001242350. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGTCACTTCCTCTTTTCCAATCTCTGTGGCAGTTTTTGCCCTAATAACCCTGCAGGTTGGTACTCAG GACAGTTTTATAGCTGCAGTGTATGAACATGCTGTCATTTTGCCAAATAAAACAGAAACACCAGTTTCT CAGGAGGATGCCTTGAATCTCATGAACGAGAATATAGACATTCTGGAGACAGCGATCAAGCAGGCAGCT GAGCAGGGTGCTCGAATCATTGTGACTCCAGAAGATGCACTTTATGGATGGAAATTTACCAGGGAAACT GTTTTCCCTTATCTGGAGGATATCCCAGACCCTCAGGTGAACTGGATTCCGTGTCAAGACCCCCACAGA TTTGGTCACACACCAGTACAAGCAAGACTCAGCTGCCTGGCCAAGGACAACTCTATCTATGTCTTGGCA AATTTGGGGGACAAAAAGCCATGTAATTCCCGTGACTCCACATGTCCTCCTAATGGCTACTTTCAATAC AATACCAATGTGGTGTATAATACAGAAGGAAAACTCGTGGCACGTTACCATAAGGTCTGCACAATGCTG AAGTGCAAAACTACTAATTTGACAACTTGTGGACGGCCAGTAGAAACTGCTTCTACAAGATTTGAAATG TTCTCCCTCAGTGGCACATTTGGAACAGAGTATGTTTTTCCTGAAGTGCTACTTACCGAAATTCATCTG TCACCTGGAAAATTTGAGGTGCTGAAAGATGGGCGTTTGGTAAACAAGAATGGATCATCTGGGCCTATA CTAACAGTGTCACTCTTTGGGAGGTGGTACACAAAGGACTCACTTTACAGCTCATGTGGGACCAGCAAT TCAGCAATAACTTACCTGCTAATATTCATATTATTAATGATCATAGCTTTGCAAAATATTGTAATGTTA TAG
Restriction Sites	SgfI-MluI
ACCN	NM_001242350
Insert Size	900 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001242350.2
RefSeq Size	1470 bp
RefSeq ORF	900 bp
Locus ID	8875
UniProt ID	O95498
Protein Families	Druggable Genome, Transmembrane
MW	33.3 kDa
Gene Summary	This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.

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