ADK (NM_001202449) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	AK
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC329655 representing NM_001202449. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGACGTCAGTCAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTTGACATCTCTGCTGTAGTG GACAAAGATTTCCTTGATAAGTTTGATGAACTTGTGAAAAAATTCAAAGTCGAATATCATGCTGGTGGC TCTACCCAGAATTCAATTAAAGTGGCTCAGTGGATGATTCAACAGCCACACAAAGCAGCAACATTTTTT GGATGCATTGGGATAGATAAATTTGGGGAGATCCTGAAGAGAAAAGCTGCTGAAGCCCATGTGGATGCT CATTACTACGAGCAGAATGAGCAGCCAACAGGAACTTGTGCTGCATGCATCACTGGTGACAACAGGTCC CTCATAGCTAATCTTGCTGCTGCCAATTGTTATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGG ATGTTGGTAGAAAAAGCAAGAGTTTGTTATATAGCAGGCTTTTTTCTTACAGTTTCCCCAGAGTCAGTA TTAAAGGTGGCTCACCATGCTTCTGAAAACAACAGGATTTTCACTTTGAATCTATCTGCACCGTTTATT AGCCAGTTCTACAAGGAATCATTGATGAAAGTTATGCCTTATGTTGATATACTTTTTGGAAATGAGACA GAAGCTGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGATAGCCAAAAAGACA CAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGAATCGTGATCTTCACCCAAGGGAGAGATGACACT ATAATGGCTACAGAAAGTGAAGTCACTGCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGAT ACCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTCTGACAAGCCTCTGACT GAATGTATCCGTGCTGGCCACTATGCAGCAAGCATCATAATTAGACGGACTGGCTGCACCTTTCCTGAG AAGCCAGACTTCCACTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001202449
Insert Size	984 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001202449.1
RefSeq Size	2234 bp
RefSeq ORF	984 bp
Locus ID	132
UniProt ID	P55263
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Purine metabolism
MW	36.6 kDa
Gene Summary	This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.

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