PDE1C (NM_001191059) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	cam-PDE 1C; DFNA74; hCam-3; Hcam3
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC329425 representing NM_001191059. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGAGTCGCCAACCAAGGAGATTGAAGAATTTGAGAGCAACTCTCTGAAATACCTGCAACCGGAACAG ATCGAGAAAATCTGGCTTCGGCTCCGCGGGCTGAGGAAATATAAGAAAACGTCCCAGAGATTACGGTCT TTGGTCAAACAATTAGAGAGAGGGGAAGCTTCAGTGGTAGATCTTAAGAAGAATTTGGAATATGCAGCC ACAGTGCTTGAATCTGTGTATATTGATGAAACAAGGAGACTCCTGGATACAGAGGATGAGCTCAGTGAC ATTCAGTCAGATGCTGTGCCTTCTGAGGTCCGAGACTGGCTGGCCTCCACCTTCACGCGGCAGATGGGG ATGATGCTCAGGAGGAGCGACGAGAAGCCCCGGTTCAAGAGCATCGTTCACGCAGTGCAGGCTGGGATA TTTGTGGAGAGAATGTATAGACGGACATCAAACATGGTTGGACTGAGCTATCCACCAGCTGTTATTGAG GCATTAAAGGATGTGGACAAGTGGTCCTTTGACGTCTTTTCCCTCAATGAGGCCAGTGGGGATCATGCA CTGAAATTTATTTTCTATGAACTACTCACACGTTATGATCTGATCAGCCGTTTCAAGATCCCCATTTCT GCACTTGTCTCATTTGTGGAGGCCCTGGAAGTGGGATACAGCAAGCACAAAAATCCTTACCATAACTTA ATGCACGCTGCCGATGTTACACAGACAGTGCATTACCTCCTCTATAAGACAGGAGTGGCGAACTGGCTG ACGGAGCTGGAGATCTTTGCTATAATCTTCTCAGCTGCCATCCATGACTACGAGCATACCGGAACCACC AACAATTTCCACATTCAGACTCGGTCTGATCCAGCTATTCTGTATAATGACAGATCTGTACTGGAGAAT CACCATTTAAGTGCAGCTTATCGCCTTCTGCAAGATGACGAGGAAATGAATATTTTGATTAACCTCTCA AAGGATGACTGGAGGGAGTTTCGAACCTTGGTAATTGAAATGGTGATGGCCACAGATATGTCTTGTCAC TTCCAACAAATCAAAGCAATGAAGACTGCTCTGCAGCAGCCAGAAGCCATTGAAAAGCCAAAAGCCTTA TCCCTTATGCTGCATACAGCAGATATTAGCCATCCAGCAAAAGCATGGGACCTCCATCATCGCTGGACA ATGTCACTCCTGGAGGAGTTCTTCAGACAGGGTGACAGAGAAGCAGAGCTGGGGCTGCCTTTTTCTCCT CTGTGTGACCGAAAGTCCACTATGGTTGCTCAGTCACAAGTAGGTTTCATTGATTTCATCGTGGAACCC ACCTTCACTGTGCTTACGGACATGACCGAGAAGATTGTGAGTCCATTAATCGATGAAACCTCTCAAACT GGTGGGACAGGACAGAGGCGTTCGAGTTTGAATAGCATCAGCTCGTCAGATGCCAAGCGATCAGGTGTC AAGACCTCTGGTTCAGAGGGAAGTGCCCCGATCAACAATTCTGTCATCTCCGTTGACTATAAGAGCTTT AAAGCTACTTGGACGGAAGTGGTGCACATCAATCGGGAGAGATGGAGGGCCAAGGTACCCAAAGAGGAG AAGGCCAAGAAGGAAGCAGAGGAAAAGGCTCGCCTGGCCGCAGAGGAGCAGCAAAAGGAAATGGAAGCC AAAAGCCAGGCTGAAGAAGGCGCATCTGGCAAAGCTGAGAAAAAGACGTCTGGAGAAACTAAGAATCAA GTCAATGGAACACGGGCAAACAAAAGTGACAACCCTCGTGGGAAAAACTCCAAAGCCGAGAAGTCATCA GGAGAACAGCAACAGAATGGTGACTTCAAAGATGGTAAAAATAAGACAGACAAGAAGGATCACTCTAAC ATCGGAAATGATTCAAAGAAAACAGATGGCACAAAACAGCGTTCTCACGGCTCACCAGCCCCAAGCACC AGCTCCACGTGTCGCCTTACGTTGCCAGTCATCAAGCCTCCTTTGCGTCATTTTAAACGCCCTGCTTAC GCATCTAGCTCCTATGCACCTTCAGTCTCAAAGAAAACTGATGAGCATCCTGCAAGGTACAAGATGCTG GATCAGAGGATCAAAATGAAAAAGATTCAGAACATCTCACATAACTGGAACAGAAAATAG
Restriction Sites	SgfI-MluI
ACCN	NM_001191059
Insert Size	2130 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001191059.1
RefSeq Size	2888 bp
RefSeq ORF	2130 bp
Locus ID	5137
UniProt ID	Q14123
Protein Families	Druggable Genome
Protein Pathways	Calcium signaling pathway, Olfactory transduction, Progesterone-mediated oocyte maturation, Purine metabolism
MW	80.8 kDa
Gene Summary	This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016] Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences result in an isoform (2) with a distinct N-terminus, compared to isoform 3. Variants 2 and 5 encode the same protein. Isoform 2 is also known as HCam-3A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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