United States
Germany
Japan
United Kingdom
China
CMKLR1 (NM_001142345) Human Untagged Clone
CAT＃: SC325015
CMKLR1 (untagged)-Human chemokine-like receptor 1 (CMKLR1), transcript variant 4
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CHEMERINR; ChemR23; DEZ; RVER1 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001142345, the custom clone sequence may differ by one or more nucleotides
ATGAGAATGGAGGATGAAGATTACAACACTTCCATCAGTTACGGTGATGAATACCCTGAT TATTTAGACTCCATTGTGGTTTTGGAGGACTTATCCCCCTTGGAAGCCAGGGTGACCAGG ATCTTCCTGGTGGTGGTCTACAGCATCGTCTGCTTCCTCGGGATTCTGGGCAATGGTCTG GTGATCATCATTGCCACCTTCAAGATGAAGAAGACAGTGAACATGGTCTGGTTCCTCAAC CTGGCAGTGGCAGATTTCCTGTTCAACGTCTTCCTCCCAATCCATATCACCTATGCCGCC ATGGACTACCACTGGGTTTTCGGGACAGCCATGTGCAAGATCAGCAACTTCCTTCTCATC CACAACATGTTCACCAGCGTCTTCCTGCTGACCATCATCAGCTCTGACCGCTGCATCTCT GTGCTCCTCCCTGTCTGGTCCCAGAACCACCGCAGCGTTCGCCTGGCTTACATGGCCTGC ATGGTCATCTGGGTCCTGGCTTTCTTCTTGAGTTCCCCATCTCTCGTCTTCCGGGACACA GCCAACCTGCATGGGAAAATATCCTGCTTCAACAACTTCAGCCTGTCCACACCTGGGTCT TCCTCGTGGCCCACTCACTCCCAAATGGACCCTGTGGGGTATAGCCGGCACATGGTGGTG ACTGTCACCCGCTTCCTCTGTGGCTTCCTGGTCCCAGTCCTCATCATCACAGCTTGCTAC CTCACCATCGTGTGCAAACTGCAGCGCAACCGCCTGGCCAAGACCAAGAAGCCCTTCAAG ATTATTGTGACCATCATCATTACCTTCTTCCTCTGCTGGTGCCCCTACCACACACTCAAC CTCCTAGAGCTCCACCACACTGCCATGCCTGGCTCTGTCTTCAGCCTGGGTTTGCCCCTG GCCACTGCCCTTGCCATTGCCAACAGCTGCATGAACCCCATTCTGTATGTTTTCATGGGT CAGGACTTCAAGAAGTTCAAGGTGGCCCTCTTCTCTCGCCTGGTCAATGCTCTAAGTGAA GATACAGGCCACTCTTCCTACCCCAGCCATAGAAGCTTTACCAAGATGTCATCAATGAAT GAGAGGACTTCTATGAATGAGAGGGAGACCGGCATGCTT |
| Restriction Sites | Please inquire |
| ACCN | NM_001142345 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001142345.1, NP_001135817.1 |
| RefSeq Size | 5110 bp |
| RefSeq ORF | 1122 bp |
| Locus ID | 1240 |
| UniProt ID | Q99788 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Gene Summary | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes isoform a. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC227056 | CMKLR1 (Myc-DDK-tagged)-Human chemokine-like receptor 1 (CMKLR1), transcript variant 4 |
CNY 3,990.00 |
|
| RC227056L3 | Lenti-ORF clone of CMKLR1 (Myc-DDK-tagged)-Human chemokine-like receptor 1 (CMKLR1), transcript variant 4 |
CNY 5,890.00 |
|
| RC227056L4 | Lenti-ORF clone of CMKLR1 (mGFP-tagged)-Human chemokine-like receptor 1 (CMKLR1), transcript variant 4 |
CNY 5,890.00 |
|
| RG227056 | CMKLR1 (tGFP-tagged) - Human chemokine-like receptor 1 (CMKLR1), transcript variant 4 |
CNY 4,370.00 |
