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Presenilin 2 (PSEN2) (NM_012486) Human Untagged Clone
CAT＃: SC324404
PSEN2 (untagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2
CNY 5,488.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AD3L; AD4; CMD1V; PS2; STM2 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_012486.1
CCAGCAGTGAGGAGACAGCCAGAAGCAAGCTTTTGGAGCTGAAGGAACCTGAGACAGAAG
CTAGTCCCCCCTCTGAATTTTACTGATGAAGAAACTGAGGCCACAGAGCTAAAGTGACTT TTCCCAAGGTCGCCCAGCGAGGACGTGGGACTTCTCAGACGTCAGGAGAGTGATGTGAGG GAGCTGTGTGACCATAGAAAGTGACGTGTTAAAAACCAGCGCTGCCCTCTTTGAAAGCCA GGGAGCATCATTCATTTAGCCTGCTGAGAAGAAGAAACCAAGTGTCCGGGATTCAGACCT CTCTGCGGCCCCAAGTGTTCGTGGGTGTGAAGCTCAGCCCTGAGGGTCTCTGGACAGCGA TCACTCAGCCTCTGGACAGCGATCACTCAGCCTCTGGACAGACAGCGATCACTCAGCCTC TGGACAGCGATCACTCAGCCTCTGGACAGCGATCACTCAGCCTCTGGACAGCGATCACTC AGCCTCTGGACAGCGATAACTCAGCCTCTGTCCCCGTCTGAGATGTTGGCAGGGACTGTC AGATTTGCCAGGCATTGTTTGAAGTTCTTCCCAGCCCAGAAACCTGCATGTGTAGATTTT GGTGCTTCCAGAGGCAGGGCTATGCTCACATTCATGGCCTCTGACAGCGAGGAAGAAGTG TGTGATGAGCGGACGTCCCTAATGTCGGCCGAGAGCCCCACGCCGCGCTCCTGCCAGGAG GGCAGGCAGGGCCCAGAGGATGGAGAGAATACTGCCCAGTGGAGAAGCCAGGAGAACGAG GAGGACGGTGAGGAGGACCCTGACCGCTATGTCTGTAGTGGGGTTCCCGGGCGGCCGCCA GGCCTGGAGGAAGAGCTGACCCTCAAATACGGAGCGAAGCATGTGATCATGCTGTTTGTG CCTGTCACTCTGTGCATGATCGTGGTGGTAGCCACCATCAAGTCTGTGCGCTTCTACACA GAGAAGAATGGACAGCTCATCTACACGCCATTCACTGAGGACACACCCTCGGTGGGCCAG CGCCTCCTCAACTCCGTGCTGAACACCCTCATCATGATCAGCGTCATCGTGGTTATGACC ATCTTCTTGGTGGTGCTCTACAAGTACCGCTGCTACAAGTTCATCCATGGCTGGTTGATC ATGTCTTCACTGATGCTGCTGTTCCTCTTCACCTATATCTACCTTGGGGAAGTGCTCAAG ACCTACAATGTGGCCATGGACTACCCCACCCTCTTGCTGACTGTCTGGAACTTCGGGGCA GTGGGCATGGTGTGCATCCACTGGAAGGGCCCTCTGGTGCTGCAGCAGGCCTACCTCATC ATGATCAGTGCGCTCATGGCCCTAGTGTTCATCAAGTACCTCCCAGAGTGGTCCGCGTGG GTCATCCTGGGCGCCATCTCTGTGTATGATCTCGTGGCTGTGCTGTGTCCCAAAGGGCCT CTGAGAATGCTGGTAGAAACTGCCCAGGAGAGAAATGAGCCCATATTCCCTGCCCTGATA TACTCATCTGCCATGGTGTGGACGGTTGGCATGGCGAAGCTGGACCCCTCCTCTCAGGGT GCCCTCCAGCTCCCCTACGACCCGGAGATGGAAGAAGACTCCTATGACAGTTTTGGGGAG CCTTCATACCCCGAAGTCTTTGAGCCTCCCTTGACTGGCTACCCAGGGGAGGAGCTGGAG GAAGAGGAGGAAAGGGGCGTGAAGCTTGGCCTCGGGGACTTCATCTTCTACAGTGTGCTG GTGGGCAAGGCGGCTGCCACGGGCAGCGGGGACTGGAATACCACGCTGGCCTGCTTCGTG GCCATCCTCATTGGCTTGTGTCTGACCCTCCTGCTGCTTGCTGTGTTCAAGAAGGCGCTG CCCGCCCTCCCCATCTCCATCACGTTCGGGCTCATCTTTTACTTCTCCACGGACAACCTG GTGCGGCCGTTCATGGACACCCTGGCCTCCCATCAGCTCTACATCTGAGGGACATGGTGT GCCACAGGCTGCAAGCTGCAGGGAATTTTCATTGGATGCAGTTGTATAGTTTTACACTCT AGTGCCATATATTTTTAAGACTTTTCTTTCCTTAAAAAATAAAGTACGTGTTTACTTGGT GAGGAGGAGGCAGAACCAGCTCTTTGGTGCCAGCTGTTTCATCACCAGACTTTGGCTCCC GCTTTGGGGAGCGCCTCGCTTCACGGACAGGAAGCACAGCAGGTTTATCCAGATGAACTG AGAAGGTCAGATTAGGGTGGGGAGAAGAGCATCCGGCATGAGGGCTGAGATGCGCAAAGA GTGTGCTCGGGAGTGGCCCCTGGCACCTGGGTGCTCTGGCTGGAGAGGAAAAGCCAGTTC CCTACGAGGAGTGTTCCCAATGCTTTGTCCATGATGTCCTTGTTATTTTATTGCCTTTAG AAACTGAGTCCTGTTCTTGTTACGGCAGTCACACTGCTGGGAAGTGGCTTAATAGTAATA TCAATAAATAGATGAGTCCTGTTAGAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_012486 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_012486.1, NP_036618.1 |
| RefSeq Size | 2233 bp |
| RefSeq ORF | 1344 bp |
| Locus ID | 5664 |
| UniProt ID | P49810 |
| Protein Families | Druggable Genome, Protease, Transmembrane |
| Protein Pathways | Alzheimer's disease, Notch signaling pathway |
| Gene Summary | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) uses an alternate splice acceptor site at exon 10 compared to transcript variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202921 | PSEN2 (Myc-DDK-tagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2 |
CNY 5,488.00 |
|
| RC202921L1 | Lenti ORF clone of Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2, Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC202921L2 | Lenti ORF clone of Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RC202921L3 | Lenti ORF clone of Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC202921L4 | Lenti ORF clone of Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG202921 | PSEN2 (tGFP-tagged) - Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2 |
CNY 4,370.00 |
|
| SC109639 | PSEN2 (untagged)-Human presenilin 2 (Alzheimer disease 4) (PSEN2), transcript variant 2 |
CNY 5,488.00 |
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