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epithelial Sodium Channel alpha (SCNN1A) (NM_001038) Human Untagged Clone
CAT＃: SC324038
SCNN1A (untagged)-Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1
CNY 7,360.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BESC2; ENaCa; ENaCalpha; LIDLS3; SCNEA; SCNN1 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001038.4
AGGGGAACAAGCTGGAGGAGCAGGACCCTAGACCTCTGCAGCCCATACCAGGTCTCATGG
AGGGGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTCATGA AGGGGAACAAGCGTGAGGAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAGCCCA CGGCGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAGCTCTTCGAGTTCT TCTGCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAACCGCA TGAAGACGGCCTTCTGGGCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGGCAAT TCGGCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTCAACT CGGACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAGGTACCCGG AAATTAAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGACCTGT ACAAATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGTCGCGACCTGCGGG GGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCCCGTC GAGCCCGTAGCGTGGCCTCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAGGACT GGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTCTACCAGACATACT CATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTGTCGA GGCTGCCAGAGACTCTGCCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTCGCCT GCCGCTTCAACCAGGTCTCCTGCAACCAGGCGAATTACTCTCACTTCCACCACCCGATGT ATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCCATGC CTGGAATCAACAACGGTCTGTCCCTGATGCTGCGCGCAGAGCAGAATGACTTCATTCCCC TGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGATGAACCTGCCTTTA TGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGGAAGG AAACCCTGGACAGACTTGGGGGCGATTATGGCGACTGCACCAAGAATGGCAGTGATGTTC CTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAGGTGTGTATTCACTCCTGCTTCC AGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAGAACG TGGAGTACTGTGACTACAGAAAGCACAGTTCCTGGGGGTACTGCTACTATAAGCTCCAGG TTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGCAGCGTGA CCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAGGAATGGG TCTTCCAGATGCTATCGCGACAGAACAATTACACCGTCAACAACAAGAGAAATGGAGTGG CCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCTGAGTCTCCCTCTG TCACGATGGTCACCCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTCGGCTCCT CGGTGTTGTCTGTGGTGGAGATGGCTGAGCTCGTCTTTGACCTGCTGGTCATCATGTTCC TCATGCTGCTCCGAAGGTTCCGAAGCCGATACTGGTCTCCAGGCCGAGGGGGCAGGGGTG CTCAGGAGGTAGCCTCCACCCTGGCATCCTCCCCTCCTTCCCACTTCTGCCCCCACCCCA TGTCTCTGTCCTTGTCCCAGCCAGGCCCTGCTCCCTCTCCAGCCTTGACAGCCCCTCCCC CTGCCTATGCCACCCTGGGCCCCCGCCCATCTCCAGGGGGCTCTGCAGGGGCCAGTTCCT CCGCCTGTCCTCTGGGGGGGCCCTGAGAGGGAAGGAGAGGTTTCTCACACCAAGGCAGAT GCTCCTCTGGTGGGAGGGTGCTGGCCCTGGCAAGATTGAAGGATGTGCAGGGCTTCCTCT CAGAGCCGCCCAAACTGCCGTTGATGTGTGGAGGGGAAGCAAGATGGGTAAGGGCTCAGG AAGTTGCTCCAAGAACAGTAGCTGATGAAGCTGCCCAGAAGTGCCTTGGCTCCAGCCCTG TACCCCTTGGTACTGCCTCTGAACACTCTGGTTTCCCCACCCAACTGCGGCTAAGTCTCT TTTTCCCTTGGATCAGCCAAGCGAAACTTGGAGCTTTGACAAGGAACTTTCCTAAGAAAC CGCTGATAACCAGGACAAAACACAACCAAGGGTACACGCAGGCATGCACGGGTTTCCTGC CCAGCGACGGCTTAAGCCAGCCCCCGACTGGCCTGGCCACACTGCTCTCCAGTAGCACAG ATGTCTGCTCCTCCTCTTGAACTTGGGTGGGAAACCCCACCCAAAAGCCCCCTTTGTTAC TTAGGCAATTCCCCTTCCCTGACTCCCGAGGGCTAGGGCTAGAGCAGACCCGGGTAAGTA AAGGCAGACCCAGGGCTCCTCTAGCCTCATACCCGTGCCCTCACAGAGCCATGCCCCGGC ACCTCTGCCCTGTGTCTTTCATACCTCTACATGTCTGCTTGAGATATTTCCTCAGCCTGA AAGTTTCCCCAACCATCTGCCAGAGAACTCCTATGCATCCCTTAGAACCCTGCTCAGACA CCATTACTTTTGTGAACGCTTCTGCCACATCTTGTCTTCCCCAAAATTGATCACTCCGCC TTCTCCTGGGCTCCCGTAGCACACTATAACATCTGCTGGAGTGTTGCTGTTGCACCATAC TTTCTTGTACATTTGTGTCTCCCTTCCCAACTAGACTGTAAGTGCCTTGCGGTCAGGGAC TGAATCTTGCCCGTTTATGTATGCTCCATGTCTAGCCCATCATCCTGCTTGGAGCAAGTA GGCAGGAGCTCAATAAATGTTTGTTGCATGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | ECoRI-NOT |
| ACCN | NM_001038 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001038.4, NP_001029.1 |
| RefSeq Size | 3171 bp |
| RefSeq ORF | 2010 bp |
| Locus ID | 6337 |
| UniProt ID | P37088 |
| Domains | ASC |
| Protein Families | Druggable Genome, Ion Channels: Other, Transmembrane |
| Protein Pathways | Taste transduction |
| Gene Summary | Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009] Transcript Variant: This variant (1, also known as alpha-ENaC1) represents the predominant transcript, and encodes isoform 1. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Expression, Transcription, and Possible Antagonistic Interaction of the Human Nedd4L Gene Variant: Implications for Essential Hypertension
,Naomi Araki, Masanari Umemura, Yohei Miyagi, Machiko Yabana, Yuko Miki, Koichi Tamura, Kazuaki Uchino, Reina Aoki, Yoshio Goshima, Satoshi Umemura, and Tomoaki Ishigami,
Hypertension, Mar 2008; 51: 773 - 777.
[SCNN1A]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209564 | SCNN1A (Myc-DDK-tagged)-Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1 |
CNY 7,352.00 |
|
| RC209564L1 | Lenti ORF clone of Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1, Myc-DDK-tagged |
CNY 9,752.00 |
|
| RC209564L2 | Lenti ORF clone of Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1, mGFP tagged |
CNY 9,752.00 |
|
| RC209564L3 | Lenti ORF clone of Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1, Myc-DDK-tagged |
CNY 9,752.00 |
|
| RC209564L4 | Lenti ORF clone of Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1, mGFP tagged |
CNY 9,752.00 |
|
| RG209564 | SCNN1A (tGFP-tagged) - Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1 |
CNY 8,952.00 |
|
| SC119542 | SCNN1A (untagged)-Human sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 1 |
CNY 7,360.00 |
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