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SMC6L1 (SMC6) (NM_024624) Human Untagged Clone
CAT＃: SC322631
SMC6 (untagged)-Human structural maintenance of chromosomes 6 (SMC6), transcript variant 2
CNY 7,608.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | hSMC6; SMC-6; SMC6L1 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for SC322631
CGCGGTTAGTACCGCGGTGGGCGCCGGGGCTCCCGGGAATCTACCTTCTCCTGCGGCCGG
CACGCGGTTCCCAGGGGGCCAGCGGCGGTCAGCCGAGGTCGAGACGCCCGCAGGGTGGCC TTAGCGGCCGGTCGTACCACGGCAGCCCCGCCGATCAGGTTCCTTTGGGAGACTTCGACT TGTTGGCGACCTGATGGCCAAAAGAAAGGAAGAAAATTTTTCCTCTCCTAAAAATGCCAA AAGGCCAAGACAAGAAGAATTGGAGGATTTTGATAAAGATGGTGACGAAGACGAATGTAA AGGTACTACTTTGACTGCAGCAGAAGTTGGAATAATTGAGAGTATTCACCTAAAAAACTT CATGTGTCATTCAATGCTTGGACCTTTTAAGTTTGGTTCTAATGTCAACTTTGTTGTTGG CAACAATGGAAGTGGGAAGAGTGCAGTACTCACAGCTCTCATAGTCGGTCTTGGTGGAAG AGCAGTTGCTACTAATAGAGGATCCTCTTTAAAAGGTTTTGTGAAAGATGGACAGAACTC TGCAGATATCTCAATAACATTGAGGAACAGAGGAGATGATGCCTTTAAAGCCAGTGTGTA TGGTAACTCTATACTTATACAGCAACACATCAGCATAGATGGAAGTCGATCTTATAAACT TAAAAGTGCAACAGGCTCCGTGGTTTCCACGAGGAAAGAAGAGCTGATTGCAATTCTTGA TCATTTTAACATCCAGGTGGATAATCCAGTTTCTGTTTTAACACAAGAAATGAGCAAGCA GTTCTTACAGTCTAAAAATGAAGGAGACAAATACAAATTCTTCATGAAAGCAACGCAACT TGAACAGATGAAGGAAGATTATTCATACATTATGGAAACGAAAGAAAGAACAAAGGAGCA GATACATCAAGGAGAAGAGCGGCTTACTGAACTAAAGCGCCAGTGTGTAGAGAAAGAGGA ACGTTTTCAAAGTATTGCTGGTTTAAGTACAATGAAGACTAATTTAGAGTCCTTGAAACA TGAAATGGCTTGGGCAGTGGTCAATGAAATTGAAAAACAATTGAATGCCATCAGAGATAA TATCAAAATTGGAGAAGATCGTGCTGCTAGACTTGACAGGAAAATGGAAGAACAGCAGGT CAGACTTAATGAGGCAGAACAAAAGTACAAGGATATTCAAGACAAACTAGAAAAGATTAG TGAAGAGACAAATGCACGAGCACCAGAATGTATGGCATTGAAAGCAGATGTTGTTGCTAA GAAAAGGGCCTATAATGAAGCTGAGGTTTTATATAACCGATCCTTAAACGAATATAAAGC ATTAAAGAAAGATGATGAGCAGCTTTGTAAACGAATTGAAGAGCTGAAAAAAAGTACTGA CCAATCTTTGGAACCTGAACGGTTGGAAAGACAAAAAAAAATATCTTGGTTAAAAGAGAG AGTAAAGGCCTTTCAAAATCAAGAAAATTCAGTCAATCAAGAGATCGAACAGTTTCAGCA AGCCATAGAAAAGGACAAAGAAGAACATGGCAAAATTAAGAGAGAAGAATTAGATGTGAA GCATGCACTGAGCTACAATCAGAGGCAACTGAAAGAATTGAAAGATAGTAAAACTGATCG ACTCAAAAGATTTGGCCCTAATGTTCCAGCTCTTCTTGAAGCCATAGATGATGCTTATAG ACAAGGACATTTTACCTATAAACCTGTAGGCCCTTTAGGAGCTTGCATTCATCTTCGGGA CCCAGAACTTGCTTTGGCTATTGAATCTTGCTTAAAAGGGCTTCTGCAGGCCTATTGTTG CCATAATCATGCTGATGAAAGGGTCCTTCAGGCACTCATGAAAAGGTTTTATTTACCAGG GACCTCACGGCCACCGATAATAGTTTCTGAGTTTCGGAATGAGATATATGATGTAAGACA CAGAGCTGCTTATCATCCAGACTTTCCAACAGTTCTGACAGCTTTAGAAATAGATAATGC GGTTGTGGCAAATAGCCTAATTGACATGAGAGGCATAGAGACAGTGCTACTAATCAAAAA TAATTCTGTAGCTCGTGCAGTAATGCAGTCCCAAAAGCCACCCAAAAATTGTAGAGAAGC TTTTACTGCTGATGGTGATCAAGTTTTTGCAGGACGTTATTATTCATCTGAAAATACAAG ACCTAAGTTCCTAAGCAGAGATGTGGATTCTGAAATAAGTGACTTGGAGAATGAGGTTGA AAATAAGACGGCCCAGATATTAAATCTTCAGCAACATTTATCTGCCCTTGAAAAAGATAT TAAACACAATGAGGAACTTCTTAAAAGGTGCCAACTACATTATAAAGAACTAAAGATGAA AATAAGAAAAAATATTTCTGAAATTCGGGAACTTGAGAACATAGAAGAACACCAGTCTGT AGATATTGCAACTTTGGAAGATGAAGCTCAGGAAAATAAAAGCAAAATGAAAATGGTTGA GGAACATATGGAGCAACAAAAAGAAAATATGGAGCATCTTAAAAGTCTGAAAATAGAAGC AGAAAATAAGTATGATGCAATTAAATTCAAAATTAATCAACTATCGGAGCTAGCAGACCC ACTTAAGGATGAATTAAACCTTGCTGATTCTGAAGTGGATAACCAAAAACGAGGGAAACG ACATTATGAAGAAAAACAAAAAGAACACTTGGATACCTTAAATAAAAAGAAACGAGAACT GGATATGAAAGAGAAAGAACTAGAGGAGAAAATGTCACAAGCAAGACAAATCTGCCCAGA GCGTATAGAAGTAGAAAAATCTGCATCAATTCTGGACAAAGAAATTAATCGATTAAGGCA GAAGATACAGGCAGAACATGCTAGTCATGGAGATCGAGAGGAAATAATGAGGCAGTACCA AGAAGCAAGAGAGACCTATCTTGATCTGGATAGTAAAGTGAGGACTTTAAAAAAGTTTAT TAAATTACTGGGAGAAATCATGGAGCACAGATTCAAGACATATCAACAATTTAGAAGGTG TTTGACTTTACGATGCAAATTATACTTTGACAACTTACTATCTCAGCGGGCCTATTGTGG AAAAATGAATTTTGACCACAAGAATGAAACTCTAAGTATATCAGTTCAGCCTGGAGAAGG AAATAAAGCTGCTTTCAATGACATGAGAGCCTTGTCTGGAGGTGAACGTTCTTTCTCCAC AGTGTGTTTTATTCTTTCCCTGTGGTCCATCGCAGAATCTCCTTTCAGATGCCTGGATGA ATTTGATGTCTACATGGATATGGTTAATAGGAGAATTGCCATGGACTTGATACTGAAGAT GGCAGATTCCCAGCGTTTTAGACAGTTTATCTTGCTCACACCTCAAAGCATGAGTTCACT TCCATCCAGTAAACTGATAAGAATTCTCCGAATGTCTGATCCTGAAAGAGGACAAACTAC ATTGCCTTTCAGACCTGTGACTCAAGAAGAAGATGATGACCAAAGGTGATTTGTAACTTA ACATGCCTTGTCCTGATGTTGAAGGATTTGTGAAGGGAAAAAAAATTCTGGACTCTTTGA TATAATAAAATGAGACTGGAGGCATTCTGAAATGAAAGAAACTCCTTTATATATCCAACC ACAATCAAACATATAAATAAGCCTGGAAAACCAACTACAACCTGCAATTTAAGATTACTA TTACTTTAAGAAAATCAATTTCATAGTATTGGTTTTAAATCTTTTTAAGTTTTTTTAATA CGATCTATTTTTATAGGTTCTTTTTCAGAAGTAAAATTTTGTACATATATACATGTACAT ATCTGTTTAGTTTGGGTTCATTTCTATAACATTTTGTAAGAAAATAAAAGTTTGAGCACC TGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_024624 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_024624.3, NP_078900.1 |
| RefSeq Size | 5151 bp |
| RefSeq ORF | 3276 bp |
| Locus ID | 79677 |
| UniProt ID | Q96SB8 |
| Domains | SMC_C |
| Gene Summary | Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208031 | SMC6 (Myc-DDK-tagged)-Human structural maintenance of chromosomes 6 (SMC6), transcript variant 2 |
CNY 7,600.00 |
|
| RC208031L3 | Lenti ORF clone of Human structural maintenance of chromosomes 6 (SMC6), transcript variant 2, Myc-DDK-tagged |
CNY 10,260.00 |
|
| RC208031L4 | Lenti ORF clone of Human structural maintenance of chromosomes 6 (SMC6), transcript variant 2, mGFP tagged |
CNY 10,260.00 |
|
| RG208031 | SMC6 (tGFP-tagged) - Human structural maintenance of chromosomes 6 (SMC6), transcript variant 2 |
CNY 9,200.00 |
|
| SC108334 | SMC6 (untagged)-Human structural maintenance of chromosomes 6 (SMC6), transcript variant 2 |
CNY 10,450.00 |
