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LAT2 (SLC7A8) (NM_012244) Human Untagged Clone
CAT＃: SC321483
SLC7A8 (untagged)-Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 1
CN¥ 3,992.00
CN¥ 7,220.00
Product images
CN¥ 1,999.00
CN¥ 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | LAT2; LPI-PC1 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_012244.2
CTTTTGAGGTTGCAATCCTACTGAGAAGGATGGAAGAAGGAGCCAGGCACCGAAACAACA
CCGAAAAGAAACACCCAGGTGGGGGCGAGTCGGACGCCAGCCCCGAGGCTGGTTCCGGAG GGGGCGGAGTAGCCCTGAAGAAAGAGATCGGATTGGTCAGTGCCTGTGGTATCATCGTAG GGAACATCATCGGCTCTGGAATCTTTGTCTCGCCAAAGGGAGTGCTGGAGAATGCTGGTT CTGTGGGCCTTGCTCTCATCGTCTGGATTGTGACGGGCTTCATCACAGTTGTGGGAGCCC TCTGCTATGCTGAACTCGGGGTCACCATCCCCAAATCTGGAGGTGACTACTCCTATGTCA AGGACATCTTCGGAGGACTGGCTGGGTTCCTGAGGCTGTGGATTGCTGTGCTGGTGATCT ACCCCACCAACCAGGCTGTCATCGCCCTCACCTTCTCCAACTACGTGCTGCAGCCGCTCT TCCCCACCTGCTTCCCCCCAGAGTCTGGCCTTCGGCTCCTGGCTGCCATCTGCTTATTGC TCCTCACATGGGTCAACTGTTCCAGTGTGCGGTGGGCCACCCGGGTTCAAGACATCTTCA CAGCTGGGAAGCTCCTGGCCTTGGCCCTGATTATCATCATGGGGATTGTACAGATATGCA AAGGAGAGTACTTCTGGCTGGAGCCAAAGAATGCATTTGAGAATTTCCAGGAACCTGACA TCGGCCTCGTCGCACTGGCTTTCCTTCAGGGCTCCTTTGCCTATGGAGGCTGGAACTTTC TGAATTACGTGACTGAGGAGCTTGTTGATCCCTACAAGAACCTTCCCAGAGCCATCTTCA TCTCCATCCCACTGGTCACATTTGTGTATGTCTTTGCCAATGTCGCTTATGTCACTGCAA TGTCCCCCCAGGAGCTGCTGGCATCCAACGCCGTCGCTGTGACTTTTGGAGAGAAGCTCC TAGGAGTCATGGCCTGGATCATGCCCATTTCTGTTGCCCTGTCCACATTTGGAGGAGTTA ATGGGTCTCTCTTCACCTCCTCTCGGCTGTTCTTCGCTGGAGCCCGAGAGGGCCACCTTC CCAGTGTGTTGGCCATGATCCACGTGAAGCGCTGCACCCCAATCCCAGCCCTGCTCTTCA CATGCATCTCCACCCTGCTGATGCTGGTCACCAGTGACATGTACACACTCATCAACTACG TGGGCTTCATCAACTACCTCTTCTATGGGGTCACGGTTGCTGGACAGATAGTCCTTCGCT GGAAGAAGCCTGATATCCCCCGCCCCATCAAGATCAACCTGCTGTTCCCCATCATCTACT TGCTGTTCTGGGCCTTCCTGCTGGTCTTCAGCCTGTGGTCAGAGCCGGTGGTGTGTGGCA TTGGCCTGGCCATCATGCTGACAGGAGTGCCTGTCTATTTCCTGGGTGTTTACTGGCAAC ACAAGCCCAAGTGTTTCAGTGACTTCATTGAGCTGCTAACCCTGGTGAGCCAGAAGATGT GTGTGGTCGTGTACCCCGAGGTGGAGCGGGGCTCAGGGACAGAGGAGGCTAATGAGGACA TGGAGGAGCAGCAGCAGCCCATGTACCAACCCACTCCCACGAAGGACAAGGACGTGGCGG GGCAGCCCCAGCCCTGAGGACCACCATTCCCTGGCTACTCTCTCCTTCCTCCCCCTTTTA TCCTACCTCCCTGCCTTGGTCCCGCCAACACATGCGAGTACACACACACCCCTCTCTGCT TTTGTCAGGCAGTGGTAGGACTTTGGTGTGGGTGGTGAGAAATTGTAAACAAAACTGACA TTCATACCCAAAGAACCAGCCTCTCACCCCAGGGTCCATGTCCCAGGCCCCACTCCAGTG CTGCCCACACTCCCAGCTGCTGGAGGAGAGGGGAGATGCCAAGGTGCCCTGCAGGACCTC CCTCCGGGCCACACCCTCAGCTGCCTCTTCAGGAACCGGAGCTCATTACTGCCTTCCCTC CCAGGGAGGCCCCTTCAGAGAGGAGAGGCCACAGGAGCTGCATTGTGGGGGGACAGGCTC AAGCAATTCTGTCCCCATCAAGGGGTCAGCTGGAGAGACCCAAGACCCTATCTGTTCACC AGGGACCCAAAATCCAAGGGGATGCTTCCCTCTGCCCTCTTTCCTGCCCCTCCCCATCAT ACCTGCACCCACCCCAGCCAGGGCTCCCTGTCCAGAATTCGGTTCTCCTCAGGACGCCAA CTCCCAGAGCTAAGGACCAAGGAGAAGAACAGCCTCTCCACCCCCAAGCCAGGCGGTTGA GGAACATATTGAGAAAGGTTCAGATTGCAGAAACCCAGCCCTGCCCCTGCCTCCTGCATC CAGCCCCCAACATGGTGCCAAAGCTTCCAGAAGCCAAAAAGCTTCTGATTTTTAAGGTAG TGGGCATCTCTCTCCTAATGACGAAGCTGCTCAGCAACTCCACCTGCCCGCCGCAGGAAG GAGCAGTCCCCTGCTATCCCTGCAGCCACTCCCAGCACACCCGCACACAGCCAGCACCAC CGCCCCCACCGTGCACTTCTCCTCTCTGGGCCTTGGCTTGGGACCAGGTACGAAGGATCC CCAAGCCCTTCAGGCCTGAGATCAGAGCCAGATCAGCCTTAAGTCACCTCCCATCCAAGA ACTTGGCCTAAAAATACTCCCCTATTTCTAACCCTCAGGACGGATCTGATATTAAATGCC TTCCCTGGGAGGAAGGGTGCTTTCCCCCTCCCTAGAGGTGCCCATTCCATACCCTGGGAG ACTGAGGAGAGCATTGGCTGAAGCCCAGTTCCTTTCCCATCCATCCCCAACTCCAATAAT CCCCCACTCCTCGCAGGTCTCAGTGTCATGCTGTCTTGGGGCAGGGTGAAAGGGTAGTGG CAGCAGGGCGCCCACTCTGGAGATCCTCAAAAAAGGCCCTCCTCTGTGGCTGGCAGCCTC TGACCTTTCCCTGGGCTTCAAAGGAAGGCTATGGAGTTTGCTGTGGGCCCTGCAACCTTC CCAGCCACTCCTGCTGCACTAAGGACTTAGGATCCTTTTATCACAAATCGGGATTCTCTC CCCCACCCCGAATTCTGTCTGCTTAAACTGGAATACACAGGAGCCCTTCCTGGCCTGGAT GGTGTCTCCCAGCTTCCCCGCCCAGCTTGCCCACCCCATAGTTGGTGAGATGCCAAGTTT GGTCTGAGTTGTGACCCCTTCAGAGTAGATGCCCGGCAGGCTGGGGTTGGCCCCTGGAGG GTCAGGGGACCATCTTCTTATTCCCTCTTTTCTCATTCCTCCAACTTCCTCCCCTCCTTC AATTATTTTTTTGTAAAGTTGATGCCTTACTTTTTGGATAAATATTTTTGAAGCTGGTAT TTCTATTTCTTTTGGATTTTTTTTAATGTAAGGTTGTTTTGGGGGATGGAGTTAGAACCT TAATGATAATTTCTTTCGTTTGGTGTAGGTTTTAGAGATTTGTTTTGTGGAGAGGTTTTT TTCTTTTGATGTAATAAAATTTAAAATGGAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_012244 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_012244.2, NP_036376.2 |
| RefSeq Size | 4237 bp |
| RefSeq ORF | 1608 bp |
| Locus ID | 23428 |
| UniProt ID | Q9UHI5 |
| Domains | aa_permeases |
| Protein Families | Druggable Genome, Transmembrane |
| Gene Summary | Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208586 | SLC7A8 (Myc-DDK-tagged)-Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 1 |
CN¥ 3,984.00 |
|
| RC208586L1 | Lenti ORF clone of Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 1, Myc-DDK-tagged |
CN¥ 6,384.00 |
|
| RC208586L2 | Lenti ORF clone of Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 1, mGFP tagged |
CN¥ 6,460.00 |
|
| RC208586L3 | Lenti ORF clone of Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 1, Myc-DDK-tagged |
CN¥ 6,460.00 |
|
| RC208586L4 | Lenti ORF clone of Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 1, mGFP tagged |
CN¥ 6,460.00 |
|
| RG208586 | SLC7A8 (tGFP-tagged) - Human solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8), transcript variant 1 |
CN¥ 5,584.00 |
