United States
Germany
Japan
United Kingdom
China
TEA domain family member 2 (TEAD2) (NM_003598) Human Untagged Clone
CAT＃: SC320274
TEAD2 (untagged)-Human TEA domain family member 2 (TEAD2)
CNY 5,488.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ETF; TEAD-2; TEF-4; TEF4 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_003598.1
CCCACTTTTCCCAAACAAAGCTCCCGGCAACTTTCTCCCTCGCAGCGCCCCGCCCGCCCG
CGGCTCCCCAGCCCCAGGCCGGGAGGCCCAGATGGGGGAACCCCGGGCTGGGGCCGCCCT GGACGATGGCAGCGGCTGGACGGGCAGTGAGGAAGGCAGTGAGGAGGGTACCGGCGGCAG TGAGGGGGCTGGGGGTGACGGGGGCCCGGATGCAGAGGGGGTGTGGAGCCCAGACATTGA GCAGAGCTTCCAGGAGGCCCTGGCCATCTATCCACCCTGCGGCCGCCGGAAAATAATTTT GTCTGATGAAGGCAAGATGTATGGTCGGAATGAACTGATCGCCCGCTACATCAAGCTGAG AACGGGGAAGACCCGAACTCGAAAACAGGTTTCTAGTCACATCCAGGTTTTGGCCCGAAG GAAATCAAGGGAAATCCAGTCCAAGTTGAAGGACCAGGTTTCCAAGGACAAGGCTTTCCA GACAATGGCAACCATGTCCTCTGCCCAGCTCATCTCCGCGCCTTCTCTGCAGGCCAAACT GGGTCCCACTGGTCCTCAGGCCTCTGAGCTTTTCCAGTTTTGGTCTGGAGGATCTGGGCC CCCCTGGAATGTTCCAGATGTGAAGCCATTCTCACAGACACCGTTCACCTTGTCACTGAC TCCCCCATCTACTGACCTCCCAGGGTACGAGCCCCCCCAAGCCCTCTCACCCCTGCCCCC ACCTACCCCATCGCCCCCAGCCTGGCAGGCTCGGGGCCTGGGCACCGCCCGGTTGCAGCT GGTAGAGTTCTCAGCCTTCGTGGAACCGCCAGATGCAGTTGATTCTTACCAGAGGCACCT GTTCGTGCACATCAGCCAGCACTGCCCCAGCCCCGGAGCGCCGCCGCTCGAGAGTGTGGA CGTCCGGCAGATCTACGACAAATTCCCTGAGAAAAAGGGTGGCCTCCGAGAGCTATATGA TCGTGGCCCCCCCCATGCCTTCTTCCTGGTCAAGTTCTGGGCGGACCTGAACTGGGGCCC AAGTGGTGAGGAGGCAGGGGCCGGTGGCAGCATCAGCAGTGGTGGCTTCTACGGAGTGAG CAGCCAGTATGAGAGCCTGGAACACATGACCCTCACCTGTTCCTCCAAGGTCTGCTCTTT TGGCAAGCAGGTGGTGGAGAAGGTGGAGACGGAACGGGCCCAGCTGGAGGACGGCAGATT TGTGTACCGCCTGCTGCGCTCGCCCATGTGCGAGTACCTGGTGAATTTCTTGCACAAGTT GCGGCAGCTGCCTGAGCGATACATGATGAACAGCGTCCTGGAAAACTTCACCATCCTCCA GGTGGTGACAAACAGAGACACCCAGGAACTGCTGCTCTGCACCGCCTATGTCTTCGAGGT CTCCACCAGCGAGCGTGGGGCCCAGCATCACATTTACCGCCTGGTCAGGGACTGAAGGGG GACCCCAAAACTGGCTCACCCCCCAGAACACCCTCCTCCCAGGGAGGGTCCTCCAGCTCA CCTCATGCTTCTTATTTGGGGAGAGGGCTGTGATGTAAAGGGGTTGACCTCAGAGGCCTA AGCAACTGGGGCCATCCCCCCCATTAGAGGGGCCCCCAAAACTTGGTTGGAGAGCTGAAC AGGCTGGGACTGAGGAAAGGATAAACCCCGATATTGGGACCTCACAGTGGGTGTCTGAAA GGACAGATCACTCCGGAGTATCAGGGATTGTGGGGACAGGAGTGAGACAACCCCCCAGGT ACAGCACTGGCTTTTCTTTTCAGCCCCTGACAGGCCACCCCCACTCCTCTGCATGTCTTG GAGAGCGCTAGTTACACATTGGCTTGTCCCCTTTACTTTTTCCCAGCCACCCCTCCCCCT GAAATTTCTGCCCCTCTCTACCACCCTCACTCCATGACCTGTGAGATCACAAAGTGAAGA TGAACCCTTTCTGTGCAGGAGCAGAGCCAGGTGGGCCCTGGACATTTTTTTTTTTTTTAA TATAACGAGATATTTATAAGTGGGTGCTAGGGTCTTGACTTTATCTCCGCTGCACAAGCA GTGTGTTGAACTTTCTAATCTCATCCCTCTCCTAAGTGAGCCCTGAGCTAGACGGTTTCC TTCCTCCCCTCTCAAAGTTTGTTTGTTTGTGTTCTGACAGAGGATAAAGCTATTTTACCA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_003598 |
| Insert Size | 2200 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_003598.1, NP_003589.1 |
| RefSeq Size | 2220 bp |
| RefSeq ORF | 1344 bp |
| Locus ID | 8463 |
| UniProt ID | Q15562 |
| Protein Families | Transcription Factors |
| Gene Summary | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology.
,null,
Human molecular genetics
,PubMed ID 28171658
[TEAD2]
|
|
Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology
,Mao, Y;Chen, X;Xu, M;Fujita, K;Motoki, K;Sasabe, T;Homma, H;Murata, M;Tagawa, K;Tamura, T;Kaye, J;Finkbeiner, S;Blandino, G;Sudol, M;Okazawa, H;,
Hum. Mol. Genet.
,PubMed ID 27619483
[TEAD2]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203526 | TEAD2 (Myc-DDK-tagged)-Human TEA domain family member 2 (TEAD2) |
CNY 5,488.00 |
|
| RC203526L1 | Lenti ORF clone of Human TEA domain family member 2 (TEAD2), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC203526L2 | Lenti ORF clone of Human TEA domain family member 2 (TEAD2), mGFP tagged |
CNY 5,890.00 |
|
| RC203526L3 | Lenti ORF clone of Human TEA domain family member 2 (TEAD2), Myc-DDK-tagged |
CNY 7,888.00 |
|
| RC203526L4 | Lenti ORF clone of Human TEA domain family member 2 (TEAD2), mGFP tagged |
CNY 7,888.00 |
|
| RG203526 | TEAD2 (tGFP-tagged) - Human TEA domain family member 2 (TEAD2) |
CNY 7,088.00 |
其它TEA domain family member 2产品
