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HMBOX1 (NM_024567) Human Untagged Clone
CAT＃: SC319800
HMBOX1 (untagged)-Human homeobox containing 1 (HMBOX1), transcript variant 1
CNY 3,656.00
| Cited in 4 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HNF1LA; HOT1; PBHNF; TAH1 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_024567.2
CCTCAAGTCTCTTTCCTCACTTCTTTCTCTTCACTTAAAACAATTTTTTTGGAGGGGTTT
TGGGGAGGAAGTGAGCGGACGCTGGGGATGGGTCTCGTAAGCGGCCGGATTGAGAGGAGG GAGGAAGCAGGGGGCTTCCGAGTGGGTGACCCAGACGCGGGCTGTGGGGTGGGGCAGTTC GTGGGGTCCGGTCCTGGAAAGGCGTCGACTGCCCCCCAACTCTTCTGGTTTCCTCTACGA TGAGCGGAAGGTTTGAATCCTGGAGGTGGGGTCTCCGGTGTGGAGTTCTGGAAACTGTGA GGTGATTTGCAGCTGGTGGAATGGAACAGTGAAGAAGCATTGGAATGGTAGATAACGCAG ATCATCTCTGGAAAGGATATTGATCCGCCTCATGTAAAGTATGCTTAGTTCCTTTCCAGT GGTTTTGCTGGAAACCATGTCTCATTATACAGATGAACCCAGATTTACCATAGAGCAGAT AGATCTGCTTCAGCGACTTCGGCGTACTGGAATGACTAAACATGAAATTCTCCATGCCTT GGAAACTTTGGACCGTCTTGATCAAGAGCATAGTGACAAGTTTGGAAGAAGGTCCAGCTA TGGAGGAAGTTCATATGGGAATAGTACTAACAATGTCCCAGCATCTTCCTCTACAGCTAC AGCTTCCACACAGACGCAGCATTCGGGAATGTCCCCGTCACCTAGCAACAGTTATGATAC TTCCCCACAGCCTTGCACTACCAATCAAAATGGGAGGGAGAATAATGAGCGATTATCTAC ATCCAATGGAAAGATGTCACCAACTCGCTACCATGCAAACAGCATGGGTCAGAGGTCATA CAGTTTTGAAGCCTCAGAAGAGGACCTAGATGTAGATGATAAAGTGGAAGAATTAATGAG GAGGGACAGCAGTGTGATAAAAGAGGAAATCAAAGCCTTTCTTGCCAATCGGAGGATTTC CCAAGCAGTTGTTGCACAGGTAACAGGTATCAGTCAGAGCCGGATCTCTCATTGGCTGTT GCAGCAGGGATCAGACCTGAGTGAACAGAAGAAAAGAGCATTTTACCGATGGTATCAACT TGAGAAGACAAACCCTGGCGCTACACTAAGTATGAGACCAGCCCCCATTCCAATAGAGGA CCCTGAATGGAGACAAACGCCTCCCCCAGTCTCTGCCACATCTGGTACTTTCCGACTGCG ACGAGGGAGTCGATTTACCTGGAGAAAGGAGTGCCTGGCTGTTATGGAAAGTTACTTCAA TGAGAATCAATACCCAGATGAAGCAAAGAGGGAAGAAATTGCAAACGCTTGCAATGCAGT TATACAGAAGCCAGGCAAAAAGCTGTCAGATCTGGAAAGAGTTACCTCCCTGAAAGTATA TAATTGGTTTGCTAACAGAAGGAAGGAGATCAAGAGGAGAGCCAATATTGAAGCAGCAAT CCTGGAGAGTCATGGGATAGATGTGCAGAGTCCAGGAGGCCACTCAAACAGTGATGATGT CGACGGGAATGACTACTCTGAGCAGGATGACAGTACGAGCCATAGTGACCACCAAGACCC CATCTCATTAGCTGTGGAAATGGCAGCAGTCAACCACACTATCTTGGCATTGGCCCGACA AGGAGCCAACGAAATCAAGACAGAGGCCCTGGATGATGACTGATCAGGGAGGTTAAACAT GACAAGTTAACTTAGTTTAGACGTAGCACCTTAGCAGACTTTCCTCGGTCCTTAACATGT GTTCTTACAGTATAACTTGCAGTTTCTTGTATGTCAGGTAGCTGTTAGGGTCTTGTTCTG TGAAGATGGCATGGTGCCCTCAGCCTTTGCATATACTCTCTCAGTATTAACTCCCAGTAA ATAATAACCAACCAACCAACCAACCAAACTTCCCTCTCCCAGCCCCCGAGGCTAGAAAAT CTTGCTGCTCCGTCTTAGCATTCCAAGAAAGTGCTTCCAGGTATTTAGATAGCCCTCAGT TCTCAAATATTAGACTACGTGTAAAATCTTGGGTACCTTTAGATTCTTGTAACACTAGTC TGTACTCCCTTTTCCTTCCCCAAGACTGATAGGATGCAAGCTGAGGTCGTGGCACAGGAA TGACAGACACCATTTGGGGAGTATCCACAGAGTCAAAGGAACACTAGAATCCCCACCTCA GCGTGAGGATAATTGATTTCCAGCTGCAATAAGCCGTGCCTCATTATAGCCACACTGTGG CTAGATTATACTTCTTTGGGTGCTGTGCTAAGAATGTCAATGGAAAAAGCCGATCTCAGA TTTTGTTTGAAGTTAACATGCCTGACACAGACATCCTTTCCTCTCACAAGCTGTGTGACT TAGTAGATAAAATACTGCCTTCTGCCTTTGGGACCATGATTAAAAACAAAGACAAAAACC AAAAGTCATTAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_024567 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_024567.2, NP_078843.2 |
| RefSeq Size | 2427 bp |
| RefSeq ORF | 1263 bp |
| Locus ID | 79618 |
| UniProt ID | Q6NT76 |
| Domains | homeobox, HNF-1_N |
| Protein Families | Transcription Factors |
| Gene Summary | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 all encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Loss of HMBOX1 promotes LPS-induced apoptosis and inhibits LPS-induced autophagy of vascular endothelial cells in mouse
,Ma, H;Su, L;He, X;Miao, J;,
Apoptosis
,PubMed ID 31583496
[HMBOX1]
|
|
The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells
,Lu, W;Su, L;Yu, Z;Zhang, S;Miao, J;,
Stem Cells International
[HMBOX1]
|
|
The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells
,null,
Stem Cells International
,PubMed ID 26880943
[HMBOX1]
|
|
HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells
,null,
Scientific Reports
,PubMed ID 26456220
[HMBOX1]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209647 | HMBOX1 (Myc-DDK-tagged)-Human homeobox containing 1 (HMBOX1), transcript variant 1 |
CNY 3,656.00 |
|
| RC209647L3 | Lenti ORF clone of Human homeobox containing 1 (HMBOX1), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209647L4 | Lenti ORF clone of Human homeobox containing 1 (HMBOX1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG209647 | HMBOX1 (tGFP-tagged) - Human homeobox containing 1 (HMBOX1), transcript variant 1 |
CNY 5,256.00 |
