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Desmin (DES) (NM_001927) Human Untagged Clone
CNY 3,656.00
| Cited in 4 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDCD3; CSM1; CSM2; LGMD1D; LGMD1E; LGMD2R |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene ORF sequence for NM_001927 edited
GAGAGAGAACTAGTCTCCCCTCGCCGCATCCACTCTCCGGCCGGCCGCCTGCCCGCCGCC TCCTCCGTGCGCCCGCCAGCCTCGCCCGCGCCGTCACCATGAGCCAGGCCTACTCGTCCA GCCAGCGCGTGTCCTCCTACCGCCGCACCTTCGGCGGGGCCCCGGGCTTCCCGCTCGGCT CCCCGCTGAGCTCGCCCGTGTTCCCGCGGGCGGGTTTCGGCTCTAAGGGCTCCTCCAGCT CGGTGACGTCCCGCGTGTACCAGGTGTCGCGCACGTCGGGCGGGGCCGGGGGCCTGGGGT CGCTGCGGGCCAGCCGGCTGGGGACCACCCGCACGCCCTCCTCCTACGGCGCAGGCGAGC TGCTGGACTTCTCACTGGCCGACGCGGTGAACCAGGAGTTTCTGACCACGCGCACCAACG AGAAGGTGGAGCTGCAGGAGCTCAATGACCGCTTCGCCAACTACATCGAGAAGGTGCGCT TCCTGGAGCAGCAGAACGCGGCGCTCGCCGCCGAAGTGAACCGGCTCAAGGGCCGCGAGC CGACGCGAGTGGCCGAGCTCTACGAGGAGGAGCTGCGGGAGCTGCGGCGCCAGGTGGAGG TGCTCACTAACCAGCGCGCGCGCGTCGACGTCGAGCGCGACAACCTGCTCGACGACCTGC AGCGGCTCAAGGCCAAGCTGCAGGAGGAGATTCAGTTGAAGGAAGAAGCAGAGAACAATT TGGCTGCCTTCCGAGCGGACGTGGATGCAGCTACTCTAGCTCGCATTGACCTGGAGCGCA GAATTGAATCTCTCAACGAGGAGATCGCGTTCCTTAAGAAAGTGCATGAAGAGGAGATCC GTGAGTTGCAGGCTCAGCTTCAGGAACAGCAGGTCCAGGTGGAGATGGACATGTCTAAGC CAGACCTCACTGCCGCCCTCAGGGATATCCGGGCTCAGTATGAGACCATCGCGGCTAAGA ACATTTCTGAAGCTGAGGAGTGGTACAAGTCGAAGGTGTCAGACCTGACCCAGGCAGCCA ACAAGAACAACGACGCCCTGCGCCAGGCCAAGCAGGAGATGATGGAATACCGACACCAGA TCCAGTCCTACACCTGCGAGATTGACGCCCTCAAGGGCACTAACGATTCCCTGATGAGGC AGATGCGGGAATTGGAGGACCGATTTGCCAGTGAGGCCAGTGGCTACCAGGACAACATTG CACGCCTGGAGGAGGAAATCCGGCACCTCAAGGATGAGATGGCCCGCCATCTGCGCGAGT ACCAGGACCTGCTCAACGTGAAGATGGCCCTGGATGTGGAGATTGCCACCTACCGGAAGC TGCTGGAGGGAGAGGAGAGCCGGATCAATCTCCCCATCCAGACCTACTCTGCCCTCAATT TCCGAGAAACCAGCCCTGAGCAAAGGGGTTCTGAGGTCCATACCAAGAAGACGGTGATGA TCAAGACCATCGAGACACGGGATGGGGAGGTCGTCAGTGAGGCCACACAGCAGCAGCATG AAGTGCTCTAAAGACAGAGACCCTCTGCCACCAGAGACCGTCCTCACCCCTGTCCTCACT GCTCCCTGAAGCCAGCCTTCTTCCATCCCAGGACACCACACCCAGCCTCAGTCCTCCCCT CACAGCCTCTGACCCCTCCTCACTGGCCATCCCTCGTGGTCCCCAACAGCGACATAGCCC ATCCCTGCCTGGTCACAGGGCATGCCCCGGCCACCTCTGCGGACCCCAGCTGTGAGCCTT GGCTGTTGGCAGTGAGTGAGCCTGGCTCTTGTGCTGGATGGAGCCCAGGCGGGAGCGGTG GCCCTGTCCCTCCCACCTCTGTGACCTCAGGCACTAGCCTTTGGCTCTGGAGACAGCCCC AGAGCAGGGTGTTGGGATACTGCAGGGCCAGGACTGAGCCCCGCAGACCTCCCCAGCCCC TAGCCCAGGAGAGAGAAAGCCAGGCAGGTAGCCAGGGGGACTAGCCCCTGTGGAGACTGG GGGGCTTGAAATTGTCCCCGTGGTCTCTTACTTTCCTTTCCCCAGCCCAGGGTGGACTTA GAAAGCAGGGGCTACAAGAGGGAATCCCCGAAGGTGCTGGAGGTGGGAGCAGGAGATTGA GAAGGAGAGAAAGTGGGTGAGATGCTGGAGAAGAGAGGAGAGGAGAGAGGCAGAGAGCGG TCTCAGGCTGGTGGGAGGGGCGCCCACCTCCCCACGCCCTCCCCTCCCCTGCTGCAGGGG CTCTGGAGAGAAACAATAAAGAGATTCACACACAAGCAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001927 |
| Insert Size | 2300 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | no |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001927.3, NP_001918.3 |
| RefSeq Size | 2268 bp |
| RefSeq ORF | 1413 bp |
| Locus ID | 1674 |
| UniProt ID | P17661 |
| Domains | filament, filament_head |
| Protein Families | Druggable Genome |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
| Gene Summary | This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] |
Citations (4)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Targeted Analysis of Whole Genome Sequence Data to Diagnose Genetic Cardiomyopathy
,Golbus, JR;Puckelwartz, MJ;Dellefave-Castillo, L;Fahrenbach, JP;Nelakuditi, V;Pesce, LL;Pytel, P;McNally, EM;,
Circ Cardiovasc Genet
,PubMed ID 25179549
[DES]
|
|
De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy.
,null,
Human molecular genetics
,PubMed ID 20829228
[DES]
|
|
De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy
,Baerbel Klauke, Sabine Kossmann, Anna Gaertner, Kristina Brand, Ines Stork, Andreas Brodehl, Mareike Dieding, Volker Walhorn, Dario Anselmetti, Désirée Gerdes, Birte Bohms, Uwe Schulz, Edzard zu Knyphausen, Matthias Vorgerd, Jan Gummert, and Hendrik Milting,
Hum. Mol. Genet., Dec 2010; 19: 4595 - 4607
[DES]
|
|
De novo desmin-mutation N116S is associated witharrhythmogenic right ventricular cardiomyopathy
,Baerbel Klauke, Sabine Kossmann, Anna Gaertner, Kristina Brand, Ines Stork, Andreas Brodehl, Mareike Dieding, Volker Walhorn, Dario Anselmetti, Désirée Gerdes, Birte Bohms, Uwe Schulz, Edzard zu Knyphausen, Matthias Vorgerd, Jan Gummert, and Hendrik Milting,
Hum. Mol. Genet., Sep 2010; 10.1093/hmg/ddq387
[DES]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205685 | DES (Myc-DDK-tagged)-Human desmin (DES) |
CNY 3,656.00 |
|
| RC205685L1 | Lenti ORF clone of Human desmin (DES), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC205685L2 | Lenti ORF clone of Human desmin (DES), mGFP tagged |
CNY 5,890.00 |
|
| RC205685L3 | Lenti ORF clone of Human desmin (DES), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC205685L4 | Lenti ORF clone of Human desmin (DES), mGFP tagged |
CNY 5,890.00 |
|
| RG205685 | DES (tGFP-tagged) - Human desmin (DES) |
CNY 5,256.00 |
