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LARP1 (NM_033551) Human Untagged Clone
CAT＃: SC318495
LARP1 (untagged)-Human La ribonucleoprotein domain family, member 1 (LARP1), transcript variant 2
CNY 24,700.00
货期*
6周
规格
Product images
经常一起买 (4)
LARP1 mouse monoclonal antibody,clone OTI4E2
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | Lar1; LARP; Lhp1 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_033551, the custom clone sequence may differ by one or more nucleotides
ATGGCCACTCAGGTGGAGCCGCTGCTGCCTGGGGGCGCCACGCTCTTGCAGGCCGAAGAG CACGGGGGGCTGGTGAGGAAGAAGCCGCCGCCGGCGCCCGAGGGCAAGGGCGAGCCCGGG CCAAACGACGTCCGCGGGGGGGAGCCGGACGGCAGCGCTCGGAGACCCCGGCCGCCCTGC GCCAAGCCGCACAAGGAGGGCACCGGGCAGCAGGAGCGCGAGAGCCCGCGGCCGCTGCAG CTGCCCGGCGCCGAAGGCCCGGCCATCAGCGACGGGGAGGAGGGCGGCGGCGAGCCAGGC GCTGGCGGAGGAGCTGCCGGAGCCGCGGGCGCGGGGCGCCGGGACTTCGTGGAAGCCCCC CCGCCCAAGGTGAACCCGTGGACTAAGAACGCATTGCCGCCGGTCCTGACCACCGTGAAC GGACAGTCCCCCCCAGAACACTCTGCTCCAGCCAAGGTGGTGAGGGCAGCTGTTCCTAAA CAGCGCAAAGGCAGCAAGGTTGGTGACTTTGGAGATGCAATCAATTGGCCCACACCTGGA GAGATAGCCCACAAGAGTGTTCAGCCACAGTCCCACAAGCCTCAGCCTACCCGTAAACTG CCACCCAAGAAGGACATGAAGGAACAGGAGAAAGGAGAAGGGAGTGATAGTAAGGAGAGT CCAAAAACCAAATCAGATGAATCAGGGGAGGAAAAGAATGGAGATGAGGATTGCCAGCGA GGCGGGCAGAAGAAGAAAGGAAACAAACACAAGTGGGTTCCATTACAAATAGACATGAAG CCTGAAGTGCCCAGAGAGAAACTGGCTTCACGCCCCACTCGCCCACCGGAGCCTAGACAC ATACCTGCCAATCGCGGAGAGATCAAAGGGTCTGAGTCTGCCACCTACGTGCCCGTGGCC CCCCCCACCCCAGCCTGGCAACCAGAGATCAAACCGGAGCCTGCCTGGCACGACCAGGAT GAGACATCGAGTGTGAAGAGTGATGGGGCTGGTGGGGCGCGGGCTTCCTTCCGTGGCCGT GGACGGGGGCGTGGTCGCGGCCGGGGACGCGGCCGGGGTGGCACTCGAACCCATTTTGAC TACCAGTTTGGCTACCGAAAGTTTGATGGTGTGGAGGGGCCTCGTACGCCCAAGTACATG AACAACATCACCTACTACTTTGACAATGTCAGCAGCACCGAGCTTTACAGTGTGGATCAG GAACTGCTCAAAGACTACATCAAGCGCCAGATTGAATACTACTTCAGCGTGGACAATTTA GAGCGAGACTTCTTCCTGCGAAGGAAAATGGATGCTGATGGTTTCCTACCCATCACCCTT ATTGCTTCCTTCCACCGAGTGCAGGCCCTTACCACTGACATTTCACTCATCTTTGCGGCC CTAAAGGACAGCAAGGTGGTGGAGATCGTTGATGAGAAAGTTCGTAGGAGGGAGGAACCA GAAAAGTGGCCTCTTCCCCCAATAGTGGATTATTCACAGACTGATTTCTCCCAGCTTCTC AACTGCCCTGAATTTGTTCCCCGTCAGCACTACCAAAAGGAGACAGAGTCGGCACCTGGC TCTCCTCGTGCAGTCACCCCAGTGCCAACCAAAACAGAGGAGGTCAGCAACCTAAAGACA CTACCCAAGGGCCTGTCTGCCAGCCTGCCTGACCTGGATTCTGAGAACTGGATTGAAGTG AAGAAGAGGCCTCGGCCATCCCCAGCACGGCCCAAGAAGTCAGAGGAGTCCAGATTTTCC CACCTGACCTCTCTGCCTCAGCAGCTGCCTTCCCAGCAGCTGATGTCCAAGGATCAGGAT GAGCAAGAGGAACTGGATTTTCTGTTTGACGAGGAGATGGAGCAGATGGATGGGCGGAAG AACACCTTCACTGCCTGGTCTGATGAGGAATCTGACTATGAGATTGATGACAGGGATGTC AACAAGATCCTCATTGTCACCCAGACACCACATTACATGCGCCGGCACCCAGGGGGGGAC CGCACAGGCAACCACACCTCGCGTGCCAAGATGAGCGCCGAACTGGCCAAGGTCATTAAT GATGGCCTCTTCTACTATGAGCAGGACCTGTGGGCTGAAAAGTTTGAACCTGAGTATTCC CAGATCAAGCAAGAAGTCGAGAACTTCAAAAAGGTCAATATGATCAGCCGGGAGCAGTTT GACACACTGACCCCTGAGCCCCCTGTGGATCCCAACCAGGAAGTTCCTCCTGGGCCACCT CGGTTCCAGCAAGTTCCTACGGATGCCCTGGCCAACAAGTTGTTTGGTGCTCCTGAGCCC TCCACCATCGCCCGCTCTCTACCAACCACTGTCCCAGAGTCACCAAACTACCGCAACACC AGGACCCCTCGCACTCCCCGGACACCACAGCTCAAAGACTCAAGCCAGACATCACGGTTT TACCCAGTGGTGAAAGAAGGACGGACACTGGATGCCAAGATGCCTCGAAAAAGAAAGACA AGACACAGTTCAAACCCACCCTTGGAGAGCCATGTGGGCTGGGTGATGGATTCCCGTGAG CACAGGCCCCGTACTGCTTCCATCAGCTCCAGCCCCTCAGAAGGGACGCCTACAGTTGGC AGCTATGGCTGTACCCCTCAGTCATTGCCCAAGTTCCAGCATCCTTCCCATGAACTGCTC AAGGAAAATGGCTTCACACAACACGTCTACCATAAGTATCGTAGGCGCTGCCTTAATGAG CGGAAACGCTTGGGCATTGGCCAGTCTCAGGAGATGAACACACTCTTCCGCTTCTGGTCC TTCTTCCTCCGAGATCACTTCAACAAAAAGATGTATGAGGAGTTCAAGCAGCTGGCTCTG GAGGACGCCAAAGAAGGCTACAGATATGGTTTGGAGTGCCTTTTTCGATACTACAGTTAT GGCCTGGAAAAGAAGTTCCGGCTGGACATATTCAAGGATTTTCAGGAGGAAACGGTGAAG GACTATGAAGCTGGCCAACTGTATGGGCTGGAGAAGTTCTGGGCCTTCTTGAAATATTCC AAAGCCAAAAATTTGGACATTGACCCCAAACTGCAAGAATACCTCGGCAAATTCCGACGT CTTGAAGACTTCCGAGTAGATCCCCCCATGGGTGAGGAGGGCAACCACAAGCGACACTCA GTGGTAGCAGGAGGTGGCGGCGGTGAGGGCAGGAAGCGGTGCCCCTCCCAGTCTTCCAGC AGGCCTGCTGCCATGATCAGCCAACCCCCTACACCACCCACCGGCCAGCCTGTCCGGGAA GATGCCAAATGGACAAGCCAGCACTCGAACACACAGACTTTGGGAAAG |
| Restriction Sites | Please inquire |
| ACCN | NM_033551 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_033551.2, NP_291029.2 |
| RefSeq Size | 7280 bp |
| RefSeq ORF | 3291 bp |
| Locus ID | 23367 |
| Gene Summary | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543).[UniProtKB/Swiss-Prot Function] |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| SC120115 | LARP1 (untagged)-Human La ribonucleoprotein domain family, member 1 (LARP1), transcript variant 2 |
CNY 1,200.00 |
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