LARP1 (NM_033551) Human Untagged Clone
CAT#: SC120115
LARP1 (untagged)-Human La ribonucleoprotein domain family, member 1 (LARP1), transcript variant 2
CNY 1,200.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Synonyms | Lar1; LARP; Lhp1 |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Sequence Data |
>NCBI ORF sequence for NM_033551, the custom clone sequence may differ by one or more nucleotides
ATGGCCACTCAGGTGGAGCCGCTGCTGCCTGGGGGCGCCACGCTCTTGCAGGCCGAAGAGCACGGGGGGC TGGTGAGGAAGAAGCCGCCGCCGGCGCCCGAGGGCAAGGGCGAGCCCGGGCCAAACGACGTCCGCGGGGG GGAGCCGGACGGCAGCGCTCGGAGACCCCGGCCGCCCTGCGCCAAGCCGCACAAGGAGGGCACCGGGCAG CAGGAGCGCGAGAGCCCGCGGCCGCTGCAGCTGCCCGGCGCCGAAGGCCCGGCCATCAGCGACGGGGAGG AGGGCGGCGGCGAGCCAGGCGCTGGCGGAGGAGCTGCCGGAGCCGCGGGCGCGGGGCGCCGGGACTTCGT GGAAGCCCCCCCGCCCAAGGTGAACCCGTGGACTAAGAACGCATTGCCGCCGGTCCTGACCACCGTGAAC GGACAGTCCCCCCCAGAACACTCTGCTCCAGCCAAGGTGGTGAGGGCAGCTGTTCCTAAACAGCGCAAAG GCAGCAAGGTTGGTGACTTTGGAGATGCAATCAATTGGCCCACACCTGGAGAGATAGCCCACAAGAGTGT TCAGCCACAGTCCCACAAGCCTCAGCCTACCCGTAAACTGCCACCCAAGAAGGACATGAAGGAACAGGAG AAAGGAGAAGGGAGTGATAGTAAGGAGAGTCCAAAAACCAAATCAGATGAATCAGGGGAGGAAAAGAATG GAGATGAGGATTGCCAGCGAGGCGGGCAGAAGAAGAAAGGAAACAAACACAAGTGGGTTCCATTACAAAT AGACATGAAGCCTGAAGTGCCCAGAGAGAAACTGGCTTCACGCCCCACTCGCCCACCGGAGCCTAGACAC ATACCTGCCAATCGCGGAGAGATCAAAGGGTCTGAGTCTGCCACCTACGTGCCCGTGGCCCCCCCCACCC CAGCCTGGCAACCAGAGATCAAACCGGAGCCTGCCTGGCACGACCAGGATGAGACATCGAGTGTGAAGAG TGATGGGGCTGGTGGGGCGCGGGCTTCCTTCCGTGGCCGTGGACGGGGGCGTGGTCGCGGCCGGGGACGC GGCCGGGGTGGCACTCGAACCCATTTTGACTACCAGTTTGGCTACCGAAAGTTTGATGGTGTGGAGGGGC CTCGTACGCCCAAGTACATGAACAACATCACCTACTACTTTGACAATGTCAGCAGCACCGAGCTTTACAG TGTGGATCAGGAACTGCTCAAAGACTACATCAAGCGCCAGATTGAATACTACTTCAGCGTGGACAATTTA GAGCGAGACTTCTTCCTGCGAAGGAAAATGGATGCTGATGGTTTCCTACCCATCACCCTTATTGCTTCCT TCCACCGAGTGCAGGCCCTTACCACTGACATTTCACTCATCTTTGCGGCCCTAAAGGACAGCAAGGTGGT GGAGATCGTTGATGAGAAAGTTCGTAGGAGGGAGGAACCAGAAAAGTGGCCTCTTCCCCCAATAGTGGAT TATTCACAGACTGATTTCTCCCAGCTTCTCAACTGCCCTGAATTTGTTCCCCGTCAGCACTACCAAAAGG AGACAGAGTCGGCACCTGGCTCTCCTCGTGCAGTCACCCCAGTGCCAACCAAAACAGAGGAGGTCAGCAA CCTAAAGACACTACCCAAGGGCCTGTCTGCCAGCCTGCCTGACCTGGATTCTGAGAACTGGATTGAAGTG AAGAAGAGGCCTCGGCCATCCCCAGCACGGCCCAAGAAGTCAGAGGAGTCCAGATTTTCCCACCTGACCT CTCTGCCTCAGCAGCTGCCTTCCCAGCAGCTGATGTCCAAGGATCAGGATGAGCAAGAGGAACTGGATTT TCTGTTTGACGAGGAGATGGAGCAGATGGATGGGCGGAAGAACACCTTCACTGCCTGGTCTGATGAGGAA TCTGACTATGAGATTGATGACAGGGATGTCAACAAGATCCTCATTGTCACCCAGACACCACATTACATGC GCCGGCACCCAGGGGGGGACCGCACAGGCAACCACACCTCGCGTGCCAAGATGAGCGCCGAACTGGCCAA GGTCATTAATGATGGCCTCTTCTACTATGAGCAGGACCTGTGGGCTGAAAAGTTTGAACCTGAGTATTCC CAGATCAAGCAAGAAGTCGAGAACTTCAAAAAGGTCAATATGATCAGCCGGGAGCAGTTTGACACACTGA CCCCTGAGCCCCCTGTGGATCCCAACCAGGAAGTTCCTCCTGGGCCACCTCGGTTCCAGCAAGTTCCTAC GGATGCCCTGGCCAACAAGTTGTTTGGTGCTCCTGAGCCCTCCACCATCGCCCGCTCTCTACCAACCACT GTCCCAGAGTCACCAAACTACCGCAACACCAGGACCCCTCGCACTCCCCGGACACCACAGCTCAAAGACT CAAGCCAGACATCACGGTTTTACCCAGTGGTGAAAGAAGGACGGACACTGGATGCCAAGATGCCTCGAAA AAGAAAGACAAGACACAGTTCAAACCCACCCTTGGAGAGCCATGTGGGCTGGGTGATGGATTCCCGTGAG CACAGGCCCCGTACTGCTTCCATCAGCTCCAGCCCCTCAGAAGGGACGCCTACAGTTGGCAGCTATGGCT GTACCCCTCAGTCATTGCCCAAGTTCCAGCATCCTTCCCATGAACTGCTCAAGGAAAATGGCTTCACACA ACACGTCTACCATAAGTATCGTAGGCGCTGCCTTAATGAGCGGAAACGCTTGGGCATTGGCCAGTCTCAG GAGATGAACACACTCTTCCGCTTCTGGTCCTTCTTCCTCCGAGATCACTTCAACAAAAAGATGTATGAGG AGTTCAAGCAGCTGGCTCTGGAGGACGCCAAAGAAGGCTACAGATATGGTTTGGAGTGCCTTTTTCGATA CTACAGTTATGGCCTGGAAAAGAAGTTCCGGCTGGACATATTCAAGGATTTTCAGGAGGAAACGGTGAAG GACTATGAAGCTGGCCAACTGTATGGGCTGGAGAAGTTCTGGGCCTTCTTGAAATATTCCAAAGCCAAAA ATTTGGACATTGACCCCAAACTGCAAGAATACCTCGGCAAATTCCGACGTCTTGAAGACTTCCGAGTAGA TCCCCCCATGGGTGAGGAGGGCAACCACAAGCGACACTCAGTGGTAGCAGGAGGTGGCGGCGGTGAGGGC AGGAAGCGGTGCCCCTCCCAGTCTTCCAGCAGGCCTGCTGCCATGATCAGCCAACCCCCTACACCACCCA CCGGCCAGCCTGTCCGGGAAGATGCCAAATGGACAAGCCAGCACTCGAACACACAGACTTTGGGAAAGTG A >OriGene 5' read for NM_033551 unedited
TTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTGGAGCGGGAATC TGAAATACCCAAATGCCTGTTTTCCTCGGTGGAGTCAACCCGAAGAGCTCCCACCTTCTC TGGATGTGCCTGGGCTTGGACTGGCTAGAATCTTTCTCTGGACTGTTGCATGTACAGTGC CTCCATCCTGGAGGCAAGAGAGTTGGGAGTGGCTCGAATCAGAGCCGTGCCCAAGATATC CCTGCTGTTGCATCGTTTGAAGCTGACGTCCTGTGTCTGTACACTGCTGCCACTGTTGTG TCCTCGCTCTGCTTGCTGTTGCCTCACGCCAGGCCCCGTCCTGCCGTGACACCCTTCATC CTACCCTTGGAACCCCAAGGCCAAGTTGGTTCAAACTGTTGGAGAACAGAGTTGGCCTGC ATCTGGAACACACTTGTCCTCAGCTTACCATCTCCTCACACCCCAGAGTGGAAAGGTGAA CACCTGCAGCTGAGGCTTGGAAACGTTTCTTGTGTTGCCCTGAAAAATCTTTGAGACCTC AGGGAGGCTCTGTCTCTCTTAAAAGGTGGAGAAAGATGCCATTCTCTCCCTAAGGTCTGG TGGAGTCTCCCCATCTTGCATACCCTTCTGCAAGCCATCTATCTCTGCTCACTCTCCAAT TGACCCGCCTGGGAACAAGGGATGAGGAGGAGTTGGGGGCTGGGGGGAATCCTGCCAGTT GGTGAAGCCCTGTGGCAGGAAGTATATGTGGACATAGAGTATACCTGATTCTCTTTCTTC ANCCCTGACTGCTTGGGTNGNGCTGTGAATGATAATGGAATGGNCTGAGTCTGCTGNTGT CAAAAGGCAGGAGGNTGATGAAGGACTGACCACATGGACTGGNATGGGTGTCGGNTTGGG CATGACTGCACGTCACTCTAATGGNGACTGGCA >OriGene 3' read for NM_033551 unedited
NCGTATTCTATGNACCGCGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTGCCTT TTCAATGTTTATTTTTATACATTTTTTTGTATTAAAAAGAAAAGCTAATTACCACAAATT ACAAAGGACTAAAGCAGGACTAGAATAATGAATGAATCACTTCAGCCTGGAAAGCAGATA CTCTCAATAATATTAATGTTATAATACAAGCTCATTCAAGTATTTTACATTTTTTTGTCC TTTTAAATATGATATCCTAGCACATAGTAAAGATAATGTACTACGAGCGTAAGGTGGAAC CTTCTCCGCAAAGCCAGATGACAAGTTTTCCTCTCCAGTGAGAAATGGGCTCCAAGTTCT TATCTTCTCTGCCACTCAGCATGGCTGAAGGGGGAGAGGGTGGGTGTTAGGGAAAATCCA GGGACCCTTCCACACAGGAGGTACTCTGGGGTTCCATTCAGGAGGGTGCCAGATAATTCA GATCACTCTACCCAGGCTTTTTGGCAAAAAACAACCCTCACCCTCCGTAACTAGTCATCT TCCTTGTCCCTCCTCCTCACTTCCCTTCCAGGGCCTTCTAAGCAGCTTACTTTCTTTTGT AAAATCAATCACCAGGAAAGGGGAAAAAAAAAAAAAAAGAGCTACAATGGAACAAAACAA AAACATTTAACAACTTTGACACAGGGGCTCAGCACCTCTATCTGAGCCCCAGGGGTCCAG GCTGGGGCACGGCTGGATGGCCCTTCTCTACTGGTAGTGCCTTTGCTCCCAAGTGCAGGA AGAGGGCTAAAGAGAAACCTGCCCCTTAACAGGGCTGAGGCACACAGACCTGCTGATGTC TGATGCCCAAAAGTTATGTTGGCCATGGACCAACCTTGGAAGGGATAGGATGAACAGG |
Restriction Sites | NotI-NotI |
ACCN | NM_033551 |
Insert Size | 2750 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_033551.1, NP_291029.1 |
RefSeq Size | 7280 bp |
RefSeq ORF | 162 bp |
Locus ID | 23367 |
Gene Summary | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543).[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC318495 | LARP1 (untagged)-Human La ribonucleoprotein domain family, member 1 (LARP1), transcript variant 2 |
CNY 24,700.00 |