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IRAG1 (NM_130385) Human Untagged Clone
CAT＃: SC318300
MRVI1 (untagged)-Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IRAG; JAW1L; MRVI1 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_130385, the custom clone sequence may differ by one or more nucleotides
CTGACTGGGGATGCCACTTCACCAGAAGGAGAAACCGACAAAAACCTGGCCAACAGAGTT CACAGTCCCCACAAGAGGCTTTCTCACCGACACTTGAAGGTGTCCACTGCCTCCCTGACA TCTGTGGACCCCGCGGGGCACATCATTGACCTGGTGAATGACCAGCTGCCAGACATCAGC ATCTCAGAGGAGGACAAGAAGAAAAACCTGGCGCTGCTGGAAGAAGCCAAGTTGGTGAGT GAGCGATTCCTGACCCGCCGTGGGAGGAAGTCCAGGAGCAGCCCCGGAGACTCCCCATCA GCTGTTTCCCCGAACCTCAGCCCCAGCGCTTCTCCTACATCCTCTCGGAGCAACTCACTT ACAGTCCCCACCCCGCCAGGTTTGGATGTGTGCAGTGGCCCGCCATCCCCTCTGCCTGGA GCACCACCACAGAAGGGGGATGAGGCCGACGTCTCTTCACCTCACCCTGGCGAGCCTAAC GTCCCCAAAGGGCTAGCTGACAGGAAGCAGAATGACCAGAGGAAAGTGTCTCAGGGCAGG CTGGCTCCTCGTCCTCCTCCAGTTGAGAAGTCCAAAGAGATTGCAATAGAACAAAAGGAA AACTTCGATCCCCTCCAGTACCCCGAGACCACACCCAAAGGCCTAGCTCCTGTTACAAAC AGCAGTGGGAAAATGGCCCTGAACAGCCCTCAGCCTGGCCCCGTGGAGAGCGAGCTGGGG AAGCAGCTCTTGAAAACGGGCTGGGAGGGCAGCCCTCTGCCGAGAAGTCCAACCCAGGAT GCGGCAGGAGTGGGTCCCCCAGCCTCCCAGGGGAGAGGCCCAGCTGGAGAGCCGATGGGG CCCGAGGCTGGCTCCAAAGCTGAGCTTCCACCCACTGTGTCCCGGCCCCCGCTGCTGCGA GGGCTCTCCTGGGACAGTGGCCCTGAAGAACCTGGCCCCCGGCTGCAGAAAGTGCTTGCC AAGCTGCCACTGGCAGAGGAAGAAAAGCGTTTTGCAGGCAAGGCCGGCGGCAAGCTGGCC AAGGCCCCTGGTCTCAAAGACTTTCAGATACAAGTGCAGCCCGTGCGGATGCAGAAACTG ACCAAGCTCCGAGAGGAGCACATCCTGATGAGAAATCAGAACTTAGTGGGGCTCAAGCTT CCAGACCTTAGTGAAGCAGCTGAGCAGGAAAAAGGGCTTCCTTCTGAACTCTCCCCAGCT ATTGAGGAAGAAGAGTCAAAGAGTGGCTTAGATGTCATGCCTAATATTTCTGATGTGCTG CTGCGCAAACTGCGGGTCCACAGGAGTCTCCCTGGAAGTGCCCCTCCACTCACTGAAAAG GAAGTTGAGAACGTGTTTGTGCAACTGTCCTTGGCCTTTAGAAATGACAGCTACACTCTG GAATCTAGAATTAACCAGGCTGAAAGGGAACGCAACCTGACAGAGGAGAACACTGAGAAA GAACTGGAAAACTTCAAAGCTTCCATTACGTCCTCAGCTTCACTCTGGCACCACTGTGAG CACCGGGAAACCTACCAGAAGTTGCTGGAGGACATCGCTGTCCTGCACCGCCTGGCTGCC CGCCTCTCCAGCCGAGCTGAGGTGGTAGGCGCCGTCCGCCAGGAAAAGCGCATGTCGAAA GCAACGGAAGTGATGATGCAGTATGTGGAGAATCTAAAGAGGACGTATGAGAAGGACCAT GCGGAGCTCATGGAGTTTAAAAAGCTTGCAAATCAGAATTCAAGCCGCAGCTGTGGCCCC TCTGAAGATGGGGTCCCTCGCACGGCACGGTCCATGTCCCTCACGCTGGGAAAGAATATG CCTCGCCGGAGGGTCAGCGTTGCTGTGGTTCCTAAGTTTAATGCCCTGAATCTGCCTGGC CAAACTCCCAGCTCATCATCCATTCCCTCCTTACCAGCCTTGTCGGAATCACCCAATGGG AAAGGCAGCCTACCTGTCACTTCAGCACTGCCTGCACTTTTGGAAAATGGAAAGACAAAT GGGGACCCAGATTGTGAAGCCTCTGCTCCTGCGCTGACCCTGAGCTGCCTGGAGGAGCTT AGTCAGGAGACCAAGGCCAGGATGGAGGAAGAAGCCTACAGCAAGGGATTCCAAGAAGGT CTAAAGAAGACCAAAGAACTTCAAGACCTGAAGGAGGAGGAGGAAGAACAGAAGAGTGAG AGTCCTGAGGAACCTGAAGAGGTAGAAGAAACTGAGGAAGAGGAAAAGGGCCCAAGAAGC AGCAAACTTGAAGAATTGGTCCATTTCTTACAAGTCATGTATCCCAAACTGTGTCAGCAC TGGCAAGTGATCTGGATGATGGCTGCAGTGATGCTGGTCTTGACTGTTGTGCTGGGGCTC TACAATTCCTATAACTCTTGTGCAGAGCAGGCTGATGGGCCCCTTGGAAGATCCACTTGC TCGGCAGCCCAGAGGGACTCCTGGTGGAGCTCAGGACTCCAGCATGAGCAGCCTACAGAG CAG |
| Restriction Sites | Please inquire |
| ACCN | NM_130385 |
| Insert Size | 6376 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_130385.2, NP_569056.3 |
| RefSeq Size | 6376 bp |
| RefSeq ORF | 2466 bp |
| Locus ID | 10335 |
| UniProt ID | Q9Y6F6 |
| Protein Families | Transmembrane |
| Protein Pathways | Vascular smooth muscle contraction |
| Gene Summary | This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011] Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC215536 | MRVI1 (Myc-DDK-tagged)-Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2 |
CNY 7,130.00 |
|
| RC215536L3 | Lenti-ORF clone of MRVI1 (Myc-DDK-tagged)-Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2 |
CNY 9,030.00 |
|
| RC215536L4 | Lenti-ORF clone of MRVI1 (mGFP-tagged)-Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2 |
CNY 9,030.00 |
|
| RG215536 | MRVI1 (tGFP-tagged) - Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2 |
CNY 7,890.00 |
|
| SC110146 | MRVI1 (untagged)-Human murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2 |
CNY 5,888.00 |
