PTPRB (NM_001109754) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC317179 representing NM_001109754. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGAGGCTGAATTTTACATGGTGATTCTTACCTGCTTGATCTTCAGGAACTCAGAAGGGTTTCAGATT GTCCATGTCCAGAAACAACAGTGTCTTTTCAAAAATGAGAAAGTGGTCGTGGGCTCATGCAACAGGACC ATCCAGAACCAGCAGTGGATGTGGACTGAGGATGAAAAGCTCCTTCATGTTAAATCTGCACTGTGCTTG GCCATCTCCAACTCTTCCCGCGGCCCCTCCCGCTCAGCCATCTTGGACCGCTGTTCCCAGGCACCCCGA TGGACCTGCTATGATCAGGAAGGCTTCCTTGAGGTGGAAAATGCCTCTCTCTTTCTCCAGAAACAAGGC TCCAGAGTAGTGGTCAAGAAGGCCAGGAAATACCTCCATAGCTGGATGAAAATAGATGTCAACAAGGAG GGAAAACTGGTCAATGAAAGCCTCTGTTTACAAAAAGCTGGCCTGGGAGCAGAAGTTTCGGTGAGGAGC ACTAGAAACACGGCTCCACCCCAGATTCTCACTACCTTTAATGCAGTTCCAGATGGCCTGGTATTCCTT ATTAGGAATACCACAGAGGCCTTCATCAGAAATGCTGCAGAAAACTACAGCCAAAACAGCAGCGAGAGG CAGCATCCCAATCTGCACATGACTGGAATTACAGACACATCATGGGTTTTGTCGACTACTCAGCCCTTC TCCAGCACCACTGAAGAGACTGGACTGGCGGAGCCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAG GCCTCCAGCCATTCTGTGTCTATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTAT AGCAGTGACACCCTGGGGGCCGCGTTGTGCCCTACCTTTCGGATAGACAACACCACATACGGATGTAAC CTTCAAGATTTACAAGCAGGAACCATCTATAACTTCAGGATTATTTCTCTGGATGAAGAGAGAACAGTG GTCTTGCAAACAGATCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAGACGACTTCAACCAGC TTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACCTCATATGAGGTGCAATTATTTGATGAAAAT AACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGTACTTCATGGAATGAATACACTTTTTTCAATCTC ACTGCTGGTAGTAAATACAATATTGCCATCACAGCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTAT ACCAATGGATCAACAGTGCCATCTCCAGTGAAAGATATTGGTATTTCCACAAAAGCCAATTCTCTCCTG ATTTCCTGGTCCCATGGTTCTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGGGATCCTA GTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTTTCACGGGCTGACCCCTGGCTACCTC TACAACCTCACTGTTATGACTGAGGCTGCAGGGCTGCAAAACTACAGGTGGAAACTAGTCAGGACAGCC CCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGTTTGACCTCTCTAAAAGTCAAATGGCAA AGACCTCCTGGAAATGTGGATTCTTACAATATCACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGA GTATTAGCACCTTGGATTACTGAAACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACT GTCAGCTGTGTCTCTGGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCAGAACATTTCCAGACAAAGTT GCAAACCTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCTGGA GACTGGGAGCAGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTCAACATCACTGTGGGAAAG GAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGGAAGACAGTATGAGGTGGAAGTCATT GTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAAGGCAGGACAGTCCCCCTGGCTGTCCTCCAG CTTCGTGTCAAACATGCCAATGAAACCTCACTGAGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAG AAATACATCATTTCCCTAGCTGACAGAGACCTCTTACTGATCCACAAGTCACTCTCCAAAGATGCCAAA GAATTCACTTTTACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAGTATTAGTGGAGAC TTAAAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTGCATGTGGCCAAC CAAGGAATGACCAGTAGTCTGTTTACTAACTGGACCCAGGCACAAGGAGACGTAGAATTTTACCAAGTC TTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCCAGTGAGACCAGCAGATACAGCTTC CACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTGGTAACAACAGTGAGTGGAGGGATCTCTTCCCGA CAAGTGGTTGTGGAGGGAAGAACAGTCCCTTCCAGTGTGAGTGGAGTAACGGTGAACAATTCCGGTCGT AATGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTATGAGGTAACATTGTCT CATGACGGCAAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGCTCCCTC ACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCACTCCTTCAGC CAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCAGCCAGGAGTGACTATTTA AGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTATGAAGTCACCATTAAAAACAAAAACAAC TTCATTCAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTGTATTTGTTCAGCTAGTCCCTGGACGG TTGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAACA ATTCCAGAGCCTGTTAAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCA GGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCTCCT TTTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGCCAATACAAAATT CTTGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAGGGCTTCACAGTTCCTAGTGCT GTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGGTGAACTGGACTCCTGGTGGG GGAGACGTTGATTCCTACACGGTGTCGGCATTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCC AAGCACGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCA GTCAGCGGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTCCAGCATCTGTCCAAGGAGTA ATTGCAGACAATGCATACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTGGCAGAA AGATATGATATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACACATCAGAGCCAGCCACCACT AAGCAACACAAATTTGAAGATCTAACACCAGGCAAGAAATACAAGATACAGATCCTAACTGTCAGTGGA GGCCTCTTTAGCAAGGAAGCCCAGACTGAAGGCCGAACAGTCCCAGCAGCTGTCACCGACCTGAGGATC ACAGAGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAAC ATCTTTTTGTACAACCCAGATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTC TCTTTCCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCT AATGAGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCCAATCGGAAC ACGACAGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGCTGATTCTC TATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCGGTTTCAAGGC CTTGTTCCTGGAAGGAAGTACGTGCTGTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAAGTCACA GCGGAGAGCAGAACAGCTCCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTG GCCATCACGTGGAAAGGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGA GATGCACTTACTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTTCGT CCAGGGAGATCCTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAACCA ATTTTTGGATCTGTGAGGACAAAGCCTGACAAGATACAAAACCTGCATTGCCGGCCTCAGAACTCCACG GCCATTGCCTGTTCTTGGATCCCTCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATG GACACCCAAGAAGTTGAGTTTTCCAGAAAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTA GTGCCCCATAAGAGGTACCTGGTGTCCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAA GACAGCACTATCACAATGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGAT GTGCTAATTAGCAAGTCTTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCT GTGAAATACTTCACAGTGGTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCAC CCTCTCCCTTCCTACCTGGAGTACAGGCACAATGCCTCCATTCGGGTGTATCAGACTAATTATTTTGCC AGCAAATGTGCCGAAAATCCTAACAGCAACTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAG AGCCTAGGTGGAAAATGCGATCCCACTCAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCC TACAGAATCAGCATTCGAGCTTTTACACAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTC TATTCAGACACATTTTTTTCTTTACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGT GTGAGTGCTGGTCTGTTTTTAATTGGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAA GTGAGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCAC TTAAACCTGGGCCAGAAAGGTAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCAT TTCATGAAGCTACAGGCTGACTCCAACTACCTTCTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGC CGAAACCAGTCATGTGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTG CCCTATGATGCCACGCGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCC AGCTACATCCCTGGCAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAG GATGACTTCTGGAAAATGGTGTGGGAACAAAACGTTCACAACATCGTCATGGTGACCCAGTGTGTTGAG AAGGGCCGAGTAAAGTGTGACCATTACTGGCCAGCGGACCAGGATTCCCTCTACTATGGGGACCTCATC CTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAA CAGCTTGATGCACACAGACTCATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAA ACCACCCAGTCTCTGATCCAGTTTGTGAGAACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGG CCCACTGTGGTGCACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTC CAGCAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTT CACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGA AAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGA GATCCAGTCTATTCAAGGCATTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites	SgfI-MluI
ACCN	NM_001109754
Insert Size	6648 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001109754.2
RefSeq Size	11332 bp
RefSeq ORF	6648 bp
Locus ID	5787
UniProt ID	P23467
Protein Families	Druggable Genome, Phosphatase
Protein Pathways	Adherens junction
MW	249.1 kDa
Gene Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

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