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PTCH1 (NM_001083605) Human Untagged Clone
CAT＃: SC316081
PTCH1 (untagged)-Human patched 1 (PTCH1), transcript variant 1c'
CNY 24,990.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BCNS; NBCCS; PTC; PTC1; PTCH |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001083605, the custom clone sequence may differ by one or more nucleotides
ATGTTTAATCCTCAACTCATGATACAGACCCCTAAAGAAGAAGGTGCTAATGTCCTGACC ACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGCCGTGTCCATGTATAC ATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCAGGAGAGCTTATCACA GAAACAGGTTACATGGATCAGATAATAGAATATCTTTACCCTTGTTTGATTATTACACCT TTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCATACCTCCTAGGTAAA CCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAAGAGTTAAAGAAAATA AACTATCAAGTGGACAGCTGGGAGGAAATGCTGAATAAGGCTGAGGTTGGTCATGGTTAC ATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCCACAGCCCCCAACAAA AATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGATGTCATGGCTTATCC AGAAAGTATATGCACTGGCAGGAGGAGTTGATTGTGGGTGGCACAGTCAAGAACAGCACT GGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTAATGACTCCCAAGCAA ATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAACTGGAACGAGGACAAA GCGGCAGCCATCCTGGAGGCCTGGCAGAGGACATATGTGGAGGTGGTTCATCAGAGTGTC GCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACCCTGGACGACATCCTG AAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTACTTACTCATGCTCGCC TATGCCTGTCTAACCATGCTGCGCTGGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCTG GCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGCCTGTGCTCATTGATC GGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTCGCTCTTGGTGTTGGT GTGGATGATGTTTTTCTTCTGGCCCACGCCTTCAGTGAAACAGGACAGAATAAAAGAATC CCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCCAGCGTGGCCCTCACG TCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCAATTCCCGCTCTGCGG GCGTTCTCCCTCCAGGCAGCGGTAGTAGTGGTGTTCAATTTTGCCATGGTTCTGCTCATT TTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGGAGACTGGATATTTTC TGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAACCTCAGGCCTACACC GACACACACGACAATACCCGCTACAGCCCCCCACCTCCCTACAGCAGCCACAGCTTTGCC CATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACGGAGTACGACCCCCAC ACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCTGTGCAGCCCGTCACC GTGACACAGGACACCCTCAGCTGCCAGAGCCCAGAGAGCACCAGCTCCACAAGGGACCTG CTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCCTGTACGAAGTGGACA CTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAACCAAAAGCCAAGGTA GTGGTGATCTTCCTTTTTCTGGGCTTGCTGGGGGTCAGCCTTTATGGCACCACCCGAGTG AGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGAGAATATGACTTTATT GCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTCACCCAGAAAGCAGAC TACCCGAATATCCAGCACTTACTTTACGACCTACACAGGAGTTTCAGTAACGTGAAGTAT GTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCACTACTTCAGAGACTGG CTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGGAAAATCATGCCAAAC AATTACAAGAATGGATCAGACGATGGAGTCCTTGCCTACAAACTCCTGGTGCAAACCGGC AGCCGCGATAAGCCCATCGACATCAGCCAGTTGACTAAACAGCGTCTGGTGGATGCAGAT GGCATCATTAATCCCAGCGCTTTCTACATCTACCTGACGGCTTGGGTCAGCAACGACCCC GTCGCGTATGCTGCCTCCCAGGCCAACATCCGGCCACACCGACCAGAATGGGTCCACGAC AAAGCCGACTACATGCCTGAAACAAGGCTGAGAATCCCGGCAGCAGAGCCCATCGAGTAT GCCCAGTTCCCTTTCTACCTCAACGGCTTGCGGGACACCTCAGACTTTGTGGAGGCAATT GAAAAAGTAAGGACCATCTGCAGCAACTATACGAGCCTGGGGCTGTCCAGTTACCCCAAC GGCTACCCCTTCCTCTTCTGGGAGCAGTACATCGGCCTCCGCCACTGGCTGCTGCTGTTC ATCAGCGTGGTGTTGGCCTGCACATTCCTCGTGTGCGCTGTCTTCCTTCTGAACCCCTGG ACGGCCGGGATCATTGTGATGGTCCTGGCGCTGATGACGGTCGAGCTGTTCGGCATGATG GGCCTCATCGGAATCAAGCTCAGTGCCGTGCCCGTGGTCATCCTGATCGCTTCTGTTGGC ATAGGAGTGGAGTTCACCGTTCACGTTGCTTTGGCCTTTCTGACGGCCATCGGCGACAAG AACCGCAGGGCTGTGCTTGCCCTGGAGCACATGTTTGCACCCGTCCTGGATGGCGCCGTG TCCACTCTGCTGGGAGTGCTGATGCTGGCGGGATCTGAGTTCGACTTCATTGTCAGGTAT TTCTTTGCTGTGCTGGCGATCCTCACCATCCTCGGCGTTCTCAATGGGCTGGTTTTGCTT CCCGTGCTTTTGTCTTTCTTTGGACCATATCCTGAGGTGTCTCCAGCCAACGGCTTGAAC CGCCTGCCCACACCCTCCCCTGAGCCACCCCCCAGCGTGGTCCGCTTCGCCATGCCGCCC GGCCACACGCACAGCGGGTCTGATTCCTCCGACTCGGAGTATAGTTCCCAGACGACAGTG TCAGGCCTCAGCGAGGAGCTTCGGCACTACGAGGCCCAGCAGGGCGCGGGAGGCCCTGCC CACCAAGTGATCGTGGAAGCCACAGAAAACCCCGTCTTCGCCCACTCCACTGTGGTCCAT CCCGAATCCAGGCATCACCCACCCTCGAACCCGAGACAGCAGCCCCACCTGGACTCAGGG TCCCTGCCTCCCGGACGGCAAGGCCAGCAGCCCCGCAGGGACCCCCCCAGAGAAGGCTTG TGGCCACCCCCCTACAGACCGCGCAGAGACGCTTTTGAAATTTCTACTGAAGGGCATTCT GGCCCTAGCAATAGGGCCCGCTGGGGCCCTCGCGGGGCCCGTTCTCACAACCCTCGGAAC CCAGCGTCCACTGCCATGGGCAGCTCCGTGCCCGGCTACTGCCAGCCCATCACCACTGTG ACGGCTTCTGCCTCCGTGACTGTCGCCGTGCACCCGCCGCCTGTCCCTGGGCCTGGGCGG AACCCCCGAGGGGGACTCTGCCCAGGCTACCCTGAGACTGACCACGGCCTGTTTGAGGAC CCCCACGTGCCTTTCCACGTCCGGTGTGAGAGGAGGGATTCGAAGGTGGAAGTCATTGAG CTGCAGGACGTGGAATGCGAGGAGAGGCCCCGGGGAAGCAGCTCCAAC |
| Restriction Sites | Please inquire |
| ACCN | NM_001083605 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001083605.1, NP_001077074.1 |
| RefSeq Size | 7658 bp |
| RefSeq ORF | 3891 bp |
| Locus ID | 5727 |
| UniProt ID | Q13635 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer |
| Gene Summary | This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017] Transcript Variant: This variant (1c') differs in the 5' UTR and has multiple differences in the 5' coding region, compared to variant 1b. These differences cause translation initiation from a downstream ATG and an isoform (S) with a shorter N-terminus, compared to isoform L. Variants 1c, 1c', 1d, and 1e encode the same isoform (S). |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217224 | PTCH1 (Myc-DDK-tagged)-Human patched 1 (PTCH1), transcript variant 1c' |
CNY 12,920.00 |
|
| RC217224L3 | Lenti-ORF clone of PTCH1 (Myc-DDK-tagged)-Human patched 1 (PTCH1), transcript variant 1c' |
CNY 14,820.00 |
|
| RC217224L4 | Lenti-ORF clone of PTCH1 (mGFP-tagged)-Human patched 1 (PTCH1), transcript variant 1c' |
CNY 14,820.00 |
|
| RG217224 | PTCH1 (tGFP-tagged) - Human patched 1 (PTCH1), transcript variant 1c' |
CNY 14,250.00 |
