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HLA-DRB4 (NM_021983) Human Untagged Clone
CAT＃: SC315937
HLA (untagged)-Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4)
CN¥ 2,400.00
CN¥ 6,270.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DR4; DRB4; HLA-DR4B; HLA-DRB4* |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_021983 edited
GGGGGGCCATAGTTCTCCCTGATTGAGACTTGCCTGCTGCTGTGACCACTGGTCTTGTCC TCTTCTCCAGCATGGTGTGTCTGAAGCTCCCTGGAGGCTCCTGTATGGCAGCGCTGACAG TGACATTGACGGTGCTGAGCTCCCCACTGGCTTTGGCTGGGGACACCCAACCACGTTTCT TGGAGCAGGCTAAGTGTGAGTGTCATTTCCTCAATGGGACGGAGCGAGTGTGGAACCTGA TCAGATACATCTATAACCAAGAGGAGTACGCGCGCTACAACAGTGACCTGGGGGAGTACC AGGCGGTGACGGAGCTGGGGCGGCCTGACGCTGAGTACTGGAACAGCCAGAAGGACCTCC TGGAGCGGAGGCGGGCCGAGGTGGACACCTACTGCAGATACAACTACGGGGTTGTGGAGA GCTTCACAGTGCAGCGGCGAGTCCAACCTAAGGTGACTGTGTATCCTTCAAAGACCCAGC CCCTGCAGCACCACAACCTCCTGGTCTGCTCTGTGAATGGTTTCTATCCAGGCAGCATTG AAGTCAGGTGGTTCCGGAACGGCCAGGAAGAGAAGGCTGGGGTGGTGTCCACAGGCCTGA TCCAGAATGGAGACTGGACCTTCCAGACCCTGGTGATGCTGGAAACAGTTCCTCGGAGTG GAGAGGTTTACACCTGCCAAGTGGAGCATCCAAGCATGATGAGCCCTCTCACGGTGCAAT GGAGTGCACGGTCTGAATCTGCACAGAGCAAGATGCTGAGTGGAGTCGGGGGCTTTGTGC TGGGCCTGCTCTTCCTTGGGACAGGGCTGTTCATCTACTTCAGGAATCAGAAAGGACACT CTGGACTTCAGCCAACAGGACTCTTGAGCTGAAGTGCAGATGACCACATTCAAGGAAGAA CCTTCTGCCCCAGCTTTGCAAGATGAAAAGCTTTCCCACTTGGCTCTTATTCTTCCACAA GAGCTTTGTCAGGACCAGGTTGTTACTGGTTCAGCAACTCTGCAGAAAATGTCCTCCCTT GTGGCTTCCTTAGCTCCTGTTCTTGGCCTGAAGCCTCACAGCTTTGATGGCAGTGCCTCA TCTTCAACAGGAGAATCACTTGTAACCCGGGAGGCAGGTTCCGGTGAGACAAGATCACGC CATTGCACTCCAGCATGGGCAAAAAGAGGTAAAAACTCCTGTCAAAAAAAAAAAAAAAAA AA >OriGene 5' read for NM_021983 unedited
ATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCACTGGTCTTGTCCTCTTCT CCAGCATGGTGTGTCTGAAGCTCCCTGGAGGCTCCTGTATGGCAGCGCTGACAGTGACAT TGACGGTGCTGAGCTCCCCACTGGCTTTGGCTGGGGACACCCAACCACGTTTCTTGGAGC AGGCTAAGTGTGAGTGTCATTTCCTCAATGGGACGGAGCGAGTGTGGAACCTGATCAGAT ACATCTATAACCAAGAGGAGTACGCGCGCTACAACAGTGACCTGGGGGAGTACCAGGCGG TGACGGAGCTGGGGCGGCCTGACGCTGAGTACTGGAACAGCCAGAAGGACCTCCTGGAGC GGAGGCGGGCCGAGGTGGACACCTACTGCAGATACAACTACGGGGTTGTGGAGAGCTTCA CAGTGCAGCGGCGAGTCCAACCTAAGGTGACTGTGTATCCTTCAAAGACCCAGCCCCTGC AGCACCACAACCTCCTGGTCTGCTCTGTGAATGGTTTCTATCCAGGCAGCATTGAAGTCA GGTGGTTCCGGAACGGCCAGGAAGAGAAGGCTGGGGTGGTGTCCACAGGCCTGATCCAGA ATGGAGACTGGACCTTCCAGACCCTGGTGATGCTGGAAACAGTTCCTCGGAGTGGAGAGG TTTACACCTGCCAAGTGGAGCATCCAAGCATGATGAGCCCTCTCACGGTGCAATGGAGTG CACGGTCTGAATCTGCACAGAGCAAGATGCTGAGTGGAGTCGGNGGCTTTGTGCTNGGCC TGCTCTTCCTTTGGACAGGNCTGTTCATCTACTTNCAGAATCAGAAGGACACTCTGGACT TTCAGCCACAGACTCTTGAGCTGAAGTGCAGATGACCACATCAGGNAGAACCTCTGCCCN ACTTGCAGATGAAAGCTTCCACTNGCTCTTATCTTCCAGAGCTTGTCAGACAGNTGTT >OriGene 3' read for NM_021983 unedited
CTATGGACCGCGTGCCGCAATTTANNGATCGGTTTTTTTTTTTTTTTTTTTGACAGGAGT TTTTACCTCTTTTTGCCCATGCTGGAGTGCAATGGCGTGATCTTGTCTCACCGGAACCTG CCTCCCGGGTTACAAGTGATTCTCCTGTTGAAGATGAGGCACTGCCATCAAAGCTGTGAG GCTTCAGGCCAAGAACAGGAGCTAAGGAAGCCACAAGGGAGGACATTTTCTGCAGAGTTG CTGAACCAGTAACAACCTGGTCCTGACAAAGCTCTTGTGGAAGAATAAGAGCCAAGTGGG AAAGCTTTTCATCTTGCAAAGCTGGGGCAGAAGGTTCTTCCTTGAATGTGGTCATCTGCA CTTCAGCTCAAGAGTCCTGTTGGCTGAAGTCCAGAGTGTCCTTTCTGATTCCTGAAGTAG ATGAACAGCCCTGTCCCAAGGAAGAGCAGGCCCAGCACAAAGCCCCCGACTCCACTCAGC ATCTTGCTCTGTGCAGATTCAGACCGTGCACTCCATTGCACCGTGAGAGGGCTCATCATG CTTGGATGCTCCACTTGGCAGGTGTAAACCTCTCCACTCCGAGGAACTGTTTCCAGCATC ACCCAGGGGCTGGGAGGTCCAGTCTCCATTCTGGATCAGGCCTGTGGACACCACCCCAGC CTTCTCTTTCTGGCCGTTTCGGGACCACCTGACTTCAATGCTGCCTGGATAGAAAACACT TCCAGAGCAGACCACGAGGTTGTGGGTGCTGCAAGGGCCTGGTCTTTTTAGGGATACACA GCCCCCTTAAGTTGGGACTCGCCGCTGCCCTGTGAAGCTTCTCCCACCCCCTAGTTGTTT TGCAGAAGTGTCCCCCTCGGCCGCCTCCCTTCAGAGGGCCTTCTGGTGTGCAGTACTAAG GTAGGGCGCCCAATTCCTACCGGTGGGACTCCCCCGGACATGTTGTACGGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_021983 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_021983.4, NP_068818.4 |
| RefSeq Size | 1193 bp |
| RefSeq ORF | 801 bp |
| Locus ID | 3126 |
| UniProt ID | P13762 |
| Domains | MHC_II_beta, ig, IGc1 |
| Protein Families | Transmembrane |
| Protein Pathways | Allograft rejection, Antigen processing and presentation, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Hematopoietic cell lineage, Systemic lupus erythematosus, Type I diabetes mellitus, Viral myocarditis |
| Gene Summary | HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202743 | HLA (Myc-DDK-tagged)-Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) |
CN¥ 2,400.00 |
|
| RC202743L1 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), Myc-DDK-tagged |
CN¥ 4,800.00 |
|
| RC202743L2 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mGFP tagged |
CN¥ 5,890.00 |
|
| RC202743L3 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), Myc-DDK-tagged |
CN¥ 5,890.00 |
|
| RC202743L4 | Lenti ORF clone of Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), mGFP tagged |
CN¥ 5,890.00 |
|
| RG202743 | HLA (tGFP-tagged) - Human major histocompatibility complex, class II, DR beta 4 (HLA-DRB4) |
CN¥ 4,000.00 |
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