CBX4 (BC014967) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	chromobox homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila); hPC2; NBP16; NS5ATP1-binding protein 16; PC2
Vector	pCMV6 series
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for BC014967, the custom clone sequence may differ by one or more nucleotides ATGGAGCTGCCAGCTGTTGGCGAGCACGTCTTCGCGGTGGAGAGCATCGAGAAGAAGCGG ATCCGCAAGGGCAGAGTGGAGTATCTGGTGAAATGGAGAGGCTGGTCGCCCAAATATAAC ACGTGGGAACCGGAGGAGAACATCCTGGACCCCAGGCTGCTGATCGCCTTCCAGAACAGG GAACGGCAGGAGCAGCTGATGGGATATCGGAAGAGAGGGCCGAAGCCCAAACCGCTAGTG GTGCAGGTGCCTACCTTTGCCCGTCGTTCCAATGTCCTGACCGGCCTCCAGGACTCCTCC ACTGACAACCGTGCCAAGCTGGATTTGGGCGCGCAGGGGAAGGGCCAGGGGCATCAGTAC GAGCTCAACAGCAAGAAGCACCACCACCACGCCGTCGGCCTGAATCTCTCCCACGTGCGC AAGCGCTGCCTCTCCGAGACCCACGGCGAGCGCGAGCCCTGCAAGAAGCGGCTGACTGCG CGCAGCATCAGCACCCCCACCTGCCTGGGGGGCAGCCCAGCCGCTGAGCGCCCGGCCGAC CTGCCACCAGCCGCCGCCCTCCCGCAGCCCGAGGTCATCCTGCTAGACTCAGACCTGGAT GAACCCATAGACTTGCGCTGCGTCAAGACGCGCAGCGAGGCCGGGGAGCCGCCCAGCTCC CTCCAGGTGAAGCCCGAGACACCGGCGTCGGCGGCGGTGGCGGTGGCGGCGGCAGCGGCA CCCACCACGACGGCGGAGAAGCCTCCAGCCGAGGCCCAGGACGAACCTGCAGAGTCGCTG AGCGAGTTCAAGCCCTTCTTTGGGAATATAATTATCACCGACGTCACCGCGAACTGCCTC ACCGTTACTTTCAAGGAGTACGTGACGGTG
Restriction Sites	Please inquire
ACCN	BC014967
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC014967.1, AAH14967.1
RefSeq Size	1578 bp
RefSeq ORF	1578 bp
Locus ID	8535
Domains	CHROMO
Protein Families	Druggable Genome, Transcription Factors
Gene Summary	E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).[UniProtKB/Swiss-Prot Function]

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