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MLH3 (NM_001040108) Human Untagged Clone
CAT＃: SC310948
MLH3 (untagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1
CN¥ 28,030.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HNPCC7 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001040108, the custom clone sequence may differ by one or more nucleotides
ATGATCAAGTGCTTGTCAGTTGAAGTACAAGCCAAATTGCGTTCTGGTTTGGCCATAAGC TCCTTGGGCCAATGTGTTGAGGAACTTGCCCTCAACAGTATTGATGCTGAAGCAAAATGT GTGGCTGTCAGGGTGAATATGGAAACCTTCCAAGTTCAAGTGATAGACAATGGATTTGGG ATGGGGAGTGATGATGTAGAGAAAGTGGGAAATCGTTATTTCACCAGTAAATGCCACTCG GTACAGGACTTGGAGAATCCAAGGTTTTATGGTTTCCGAGGAGAGGCCTTGGCAAATATT GCTGACATGGCCAGTGCTGTGGAAATTTCGTCCAAGAAAAACAGGACAATGAAAACTTTT GTGAAACTGTTTCAGAGTGGAAAAGCCCTGAAAGCTTGTGAAGCTGATGTGACTAGAGCA AGCGCTGGGACTACTGTAACAGTGTATAACCTATTTTACCAGCTTCCTGTAAGGAGGAAA TGCATGGACCCTAGACTGGAGTTTGAGAAGGTTAGGCAGAGAATAGAAGCTCTCTCACTC ATGCACCCTTCCATTTCTTTCTCTTTGAGAAATGATGTTTCTGGTTCCATGGTTCTTCAG CTCCCTAAAACCAAAGACGTATGTTCCCGATTTTGTCAAATTTATGGATTGGGAAAGTCC CAAAAGCTAAGAGAAATAAGTTTTAAATATAAAGAGTTTGAGCTTAGTGGCTATATCAGC TCTGAAGCACATTACAACAAGAATATGCAGTTTTTGTTTGTGAACAAAAGACTAGTTTTA AGGACAAAGCTACATAAACTCATTGACTTTTTATTAAGGAAAGAAAGTATTATATGCAAG CCAAAGAATGGTCCCACCAGTAGGCAAATGAATTCAAGTCTTCGGCACCGGTCTACCCCA GAACTCTATGGCATATATGTAATTAATGTGCAGTGCCAATTCTGTGAGTATGATGTGTGC ATGGAGCCAGCCAAAACTCTGATTGAATTTCAGAACTGGGACACTCTCTTGTTTTGCATT CAGGAAGGAGTGAAAATGTTTTTAAAGCAAGAAAAATTATTTGTGGAATTATCAGGTGAG GATATTAAGGAATTTAGTGAAGATAATGGTTTTAGTTTATTTGATGCTACTCTTCAGAAG CGTGTGACTTCCGATGAGAGGAGCAATTTCCAGGAAGCATGTAATAATATTTTAGATTCC TATGAGATGTTTAATTTGCAGTCAAAAGCTGTGAAAAGAAAAACTACTGCAGAAAACGTA AACACACAGAGTTCTAGGGATTCAGAAGCTACCAGAAAAAATACAAATGATGCATTTTTG TACATTTATGAATCAGGTGGTCCAGGCCATAGCAAAATGACAGAGCCATCTTTACAAAAC AAAGACAGCTCTTGCTCAGAATCAAAGATGTTAGAACAAGAGACAATTGTAGCATCAGAA GCTGGAGAAAATGAGAAACATAAAAAATCTTTCCTGGAACATAGCTCTTTAGAAAATCCG TGTGGAACCAGTTTAGAAATGTTTTTAAGCCCTTTTCAGACACCATGTCACTTTGAGGAG AGTGGGCAGGATCTAGAAATATGGAAAGAAAGTACTACTGTTAATGGCATGGCTGCCAAC ATCTTGAAAAATAATAGAATTCAGAATCAACCAAAGAGATTTAAAGATGCTACTGAAGTG GGATGCCAGCCTCTGCCTTTTGCAACAACATTATGGGGAGTACATAGTGCTCAGACAGAG AAAGAGAAAAAAAAAGAATCTAGCAATTGTGGAAGAAGAAATGTTTTTAGTTATGGGCGA GTTAAATTATGTTCCACTGGCTTTATAACTCATGTAGTACAAAATGAAAAAACTAAATCA ACTGAAACAGAACATTCATTTAAAAATTATGTTAGACCTGGTCCCACACGTGCCCAAGAA ACATTTGGAAATAGAACACGTCATTCAGTTGAAACTCCAGACATCAAAGATTTAGCCAGC ACTTTAAGTAAAGAATCTGGTCAATTGCCCAACAAAAAAAATTGCAGAACGAATATAAGT TATGGGCTAGAGAATGAACCTACAGCAACTTATACAATGTTTTCTGCTTTTCAGGAAGGT AGCAAAAAATCACAAACAGATTGCATATTATCTGATACATCCCCCTCTTTCCCCTGGTAT AGACACGTTTCCAATGATAGTAGGAAAACAGATAAATTAATTGGTTTCTCCAAACCAATC GTCCGTAAGAAGCTAAGCTTGAGTTCACAGCTAGGATCTTTAGAGAAGTTTAAGAGGCAA TATGGGAAGGTTGAAAATCCTCTGGATACAGAAGTAGAGGAAAGTAATGGAGTCACTACC AATCTCAGTCTTCAAGTTGAACCTGACATTCTGCTGAAGGACAAGAACCGCTTAGAGAAC TCTGATGTTTGTAAAATCACTACTATGGAGCATAGTGATTCAGATAGTAGTTGTCAACCA GCAAGCCACATCCTTAACTCAGAGAAGTTTCCATTCTCCAAGGATGAAGATTGTTTAGAA CAACAGATGCCTAGTTTGAGAGAAAGTCCTATGACCCTGAAGGAGTTATCTCTCTTTAAT AGAAAACCTTTGGACCTTGAGAAGTCATCTGAATCACTAGCCTCTAAATTATCCAGACTG AAGGGTTCCGAAAGAGAAACTCAAACAATGGGGATGATGAGTCGTTTTAATGAACTTCCA AATTCAGATTCCAGTAGGAAAGACAGCAAGTTGTGCAGTGTGTTAACACAAGATTTTTGT ATGTTATTTAACAACAAGCATGAAAAAACAGAGAATGGTGTCATCCCAACATCAGATTCT GCCACACAGGATAATTCCTTTAATAAAAATAGTAAAACACATTCTAACAGCAATACAACA GAGAACTGTGTGATATCAGAAACTCCTTTGGTATTGCCCTATAATAATTCTAAAGTTACC GGTAAAGATTCAGATGTTCTTATCAGAGCCTCAGAACAACAGATAGGAAGTCTTGACTCT CCCAGTGGAATGTTAATGAATCCGGTAGAAGATGCCACAGGTGACCAAAATGGAATTTGT TTTCAGAGTGAGGAATCTAAAGCAAGAGCTTGTTCTGAAACTGAAGAGTCAAACACGTGT TGTTCAGATTGGCAGCGGCATTTCGATGTAGCCCTGGGAAGAATGGTTTATGTCAACAAA ATGACTGGACTCAGCACATTCATTGCCCCAACTGAGGACATTCAGGCTGCTTGTACTAAA GACCTGACAACTGTGGCTGTGGATGTTGTACTTGAGAATGGGTCTCAGTACAGGTGTCAA CCTTTTAGAAGCGACCTTGTTCTTCCTTTCCTTCCGAGAGCTCGAGCAGAGAGGACTGTG ATGAGACAGGATAACAGAGATACTGTGGATGATACTGTTAGTAGCGAATCGCTTCAGTCT TTGTTCTCAGAATGGGACAATCCAGTATTTGCCCGTTATCCAGAGGTTGCTGTTGATGTA AGCAGTGGCCAGGCTGAGAGCTTAGCAGTTAAAATTCACAACATCTTGTATCCCTATCGT TTCACCAAAGGAATGATTCATTCAATGCAGGTTCTCCAGCAAGTAGATAACAAGTTTATT GCCTGTTTGATGAGCACTAAGACTGAAGAGAATGGCGAGGCAGGTGGGAACCTGCTCGTG CTGGTGGATCAGCACGCTGCCCATGAGCGTATACGTCTGGAGCAGCTTATCATTGATTCC TACGAGAAGCAACAGGCACAAGGCTCTGGTCGGAAAAAATTACTGTCTTCTACTCTAATT CCTCCGCTAGAGATAACAGTGACAGAGGAACAAAGGAGACTCTTATGGTGTTACCACAAA AATCTGGAAGATCTGGGCCTTGAATTTGTATTTCCAGACACTAGTGATTCTCTGGTCCTT GTGGGAAAAGTACCACTATGTTTTGTGGAAAGAGAAGCCAATGAACTTCGGAGAGGAAGA TCTACTGTGACCAAGAGTATTGTGGAGGAATTTATCCGAGAACAACTGGAGCTACTCCAG ACCACCGGAGGCATCCAAGGGACATTGCCACTGACTGTCCAGAAGGTGTTGGCATCCCAA GCCTGCCATGGGGCCATTAAGTTTAATGATGGCCTGAGCTTACAGGAAAGTTGCCGCCTT ATTGAAGCTCTGTCCTCATGCCAGCTGCCATTCCAGTGTGCTCACGGGAGACCTTCTATG CTGCCGTTAGCTGACATAGACCACTTGGAACAGGAAAAACAGATTAAACCCAACCTCACT AAACTTCGCAAAATGGCCCAGGCCTGGCGTCTCTTTGGAAAAGCAGAGTGTGATACAAGG CAGAGCCTGCAGCAATCCATGCCTCCCTGTGAGCCACCATGA |
| Restriction Sites | Please inquire |
| ACCN | NM_001040108 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001040108.1, NP_001035197.1 |
| RefSeq Size | 7911 bp |
| RefSeq ORF | 4362 bp |
| Locus ID | 27030 |
| UniProt ID | Q9UHC1 |
| Protein Families | Druggable Genome |
| Protein Pathways | Mismatch repair |
| Gene Summary | This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221591 | MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CN¥ 14,540.00 |
|
| RC221591L3 | Lenti-ORF clone of MLH3 (Myc-DDK-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CN¥ 16,440.00 |
|
| RC221591L4 | Lenti-ORF clone of MLH3 (mGFP-tagged)-Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CN¥ 16,440.00 |
|
| RG221591 | MLH3 (tGFP-tagged) - Human mutL homolog 3 (E. coli) (MLH3), transcript variant 1 |
CN¥ 15,960.00 |
