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MSH3 (NM_002439) Human Untagged Clone
CAT＃: SC309971
MSH3 (untagged)-Human mutS homolog 3 (E. coli) (MSH3)
CNY 11,888.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DUP; FAP4; MRP1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002439 edited
AGATCTGGTACCGAGCGGTGGCCAGGGCAGGTCCCCGTTCTTGCCGATGCCCATGTTCTG GGACACAGCGACGATGCAGTTTAGCGAACCAACCATGACAGCAGCGGGAGGACCTCCGAG CCCGCTCGTTACAGCAGAACGCGCGGTCAAGTTTGGCGCGAAATTGTGGCCGCCCCGCCC CCCTCGTCCCCATTTGTGCAGGCGAGGCCCCGCCCCCCCGCCCCGGCGCACGCAGGGTCG CGGCGTGCTCGCGCCCGCAGACGCCTGGGAACTGCGGCCGCGGGCTCGCGCTCCTCGCCA GGCCCTGCCGCCGGGCTGCCATCCTTGCCCTGCCATGTCTCGCCGGAAGCCTGCGTCGGG CGGCCTCGCTGCCTCCAGCTCAGCCCCTGCGAGGCAAGCGGTTTTGAGCCGATTCTTCCA GTCTACGGGAAGCCTGAAATCCACCTCCTCCTCCACAGGTGCAGCCGACCAGGTGGACCC TGGCGCTGCAGCGGCTGCAGCGGCCGCAGCGGCCGCAGCGCCCCCAGCGCCCCCAGCTCC CGCCTTCCCGCCCCAGCTGCCGCCGCACGTAGCTACAGAAATTGACAGAAGAAAGAAGAG ACCATTGGAAAATGATGGGCCTGTTAAAAAGAAAGTAAAGAAAGTCCAACAAAAGGAAGG AGGAAGTGATCTGGGAATGTCTGGCAACTCTGAGCCAAAGAAATGTCTGAGGACCAGGAA TGTTTCAAAGTCTCTGGAAAAATTGAAAGAATTCTGCTGCGATTCTGCCCTTCCTCAAAG TAGAGTCCAGACAGAATCTCTGCAGGAGAGATTTGCAGTTCTGCCAAAATGTACTGATTT TGATGATATCAGTCTTCTACACGCAAAGAATGCAGTTTCTTCTGAAGATTCGAAACGTCA AATTAATCAAAAGGACACAACACTTTTTGATCTCAGTCAGTTTGGATCATCAAATACAAG TCATGAAAATTTACAGAAAACTGCTTCCAAATCAGCTAACAAACGGTCCAAAAGCATCTA TACGCCGCTAGAATTACAATACATAGAAATGAAGCAGCAGCACAAAGATGCAGTTTTGTG TGTGGAATGTGGATATAAGTATAGATTCTTTGGGGAAGATGCAGAGATTGCAGCCCGAGA GCTCAATATTTATTGCCATTTAGATCACAACTTTATGACAGCAAGTATACCTACTCACAG ACTGTTTGTTCATGTACGCCGCCTGGTGGCAAAAGGATATAAGGTGGGAGTTGTGAAGCA AACTGAAACTGCAGCATTAAAGGCCATTGGAGACAACAGAAGTTCACTCTTTTCCCGGAA ATTGACTGCCCTTTATACAAAATCTACACTTATTGGAGAAGATGTGAATCCCCTAATCAA GCTGGATGATGCTGTAAATGTTGATGAGATAATGACTGATACTTCTACCAGCTATCTTCT GTGCATCTCTGAAAATAAGGAAAATGTTAGGGACAAAAAAAAGGGCAACATTTTTATTGG CATTGTGGGAGTGCAGCCTGCCACAGGCGAGGTTGTGTTTGATAGTTTCCAGGACTCTGC TTCTCGTTCAGAGCTAGAAACCCGGATGTCAAGCCTGCAGCCAGTAGAGCTGCTGCTTCC TTCGGCCTTGTCCGAGCAAACAGAGGCGCTCATCCACAGAGCCACATCTGTTAGTGTGCA GGATGACAGAATTCGAGTCGAAAGGATGGATAACATTTATTTTGAATACAGCCATGCTTT CCAGGCAGTTACAGAGTTTTATGCAAAAGATACAGTTGACATCAAAGGTTCTCAAATTAT TTCTGGCATTGTTAACTTAGAGAAGCCTGTGATTTGCTCTTTGGCTGCCATCATAAAATA CCTCAAAGAATTCAACTTGGAAAAGATGCTCTCCAAACCTGAGAATTTTAAACAGCTATC AAGTAAAATGGAATTTATGACAATTAATGGAACAACATTAAGGAATCTGGAAATCCTACA GAATCAGACTGATATGAAAACCAAAGGAAGTTTGCTGTGGGTTTTAGACCACACTAAAAC TTCATTTGGGAGACGGAAGTTAAAGAAGTGGGTGACCCAGCCACTCCTTAAATTAAGGGA AATAAATGCCCGGCTTGATGCTGTATCGGAAGTTCTCCATTCAGAATCTAGTGTGTTTGG TCAGATAGAAAATCATCTACGTAAATTGCCCGACATAGAGAGGGGACTCTGTAGCATTTA TCACAAAAAATGTTCTACCCAAGAGTTCTTCTTGATTGTCAAAACTTTATATCACCTAAA GTCAGAATTTCAAGCAATAATACCTGCTGTTAATTCCCACATTCAGTCAGACTTGCTCCG GACCGTTATTTTAGAAATTCCTGAACTCCTCAGTCCAGTGGAGCATTACTTAAAGATACT CAATGAACAAGCTGCCAAAGTTGGGGATAAAACTGAATTATTTAAAGACCTTTCTGACTT CCCTTTAATAAAAAAGAGGAAGGATGAAATTCAAGGTGTTATTGACGAGATCCGAATGCA TTTGCAAGAAATACGAAAAATACTAAAAAATCCTTCTGCACAATATGTGACAGTATCAGG ACAGGAGTTTATGATAGAAATAAAGAACTCTGCTGTATCTTGTATACCAACTGATTGGGT AAAGGTTGGAAGCACAAAAGCTGTGAGCCGCTTTCACTCTCCTTTTATTGTAGAAAATTA CAGACATCTGAATCAGCTCCGGGAGCAGCTAGTCCTTGACTGCAGTGCTGAATGGCTTGA TTTTCTAGAGAAATTCAGTGAACATTATCACTCCTTGTGTAAAGCAGTGCATCACCTAGC AACTGTTGACTGCATTTTCTCCCTGGCCAAGGTCGCTAAGCAAGGAGATTACTGCAGACC AACTGTACAAGAAGAAAGAAAAATTGTAATAAAAAATGGAAGGCACCCTGTGATTGATGT GTTGCTGGGAGAACAGGATCAATATGTCCCAAATAATACAGATTTATCAGAGGACTCAGA GAGAGTAATGATAATTACCGGACCAAACATGGGTGGAAAGAGCTCCTACATAAAACAAGT TGCATTGATTACCATCATGGCTCAGATTGGCTCCTATGTTCCTGCAGAAGAAGCGACAAT TGGGATTGTGGATGGCATTTTCACAAGGATGGGTGCTGCAGACAATATATATAAAGGACA GAGTACATTTATGGAAGAACTGACTGACACAGCAGAAATAATCAGAAAAGCAACATCACA GTCCTTGGTTATCTTGGATGAACTAGGAAGAGGGACGAGCACTCATGATGGAATTGCCAT TGCCTATGCTACACTTGAGTATTTCATCAGAGATGTGAAATCCTTAACCCTGTTTGTCAC CCATTATCCGCCAGTTTGTGAACTAGAAAAAAATTACTCACACCAGGTGGGGAATTACCA CATGGGATTCTTGGTCAGTGAGGATGAAAGCAAACTGGATCCAGGCGCAGCAGAACAAGT CCCTGATTTTGTCACCTTCCTTTACCAAATAACTAGAGGAATTGCAGCAAGGAGTTATGG ATTAAATGTGGCTAAACTAGCAGATGTTCCTGGAGAAATTTTGAAGAAAGCAGCTCACAA GTCAAAAGAGCTGGAAGGATTAATAAATACGAAAAGAAAGAGACTCAAGTATTTTGCAAA GTTATGGACGATGCATAATGCACAAGACCTGCAGAAGTGGACAGAGGAGTTCAACATGGA AGAAACACAGACTTCTCTTCTTCATTAAAATGAAGACTACATTTGTGAACAAAAAATGGA GAATTAAAAATACCAACTGTACAAAATAACTCTCCAGTAACAGCCTATCTTTGTGTGACA TGTGAGCATAAAATTATGACCATGGTATATTCCTATTGGAAACAGAGAGGTTTTTCTGAA GACAGTCTTTTTCAAGTTTCTGTCTTCCTAACTTTTCTACGTATAAACACTCTTGAATAG ACTTCCACTTTGTAATTAGAAAATTTTATGGACAGTAAGTCCAGTAAAGCCTTAAGTGGC AGAATATAATTCCCAAGCTTTTGGAGGGTGATATAAAAATTTACTTGATATTTTTATTTG TTTCAGTTCAGATAATTGGCAACTGGGTGAATCTGGCAGGAATCTATCCATTGAACTAAA ATAATTTTATTATGCAACCAGTTTATCCACCAAGAACATAAGAATTTTTTATAAGTAGAA AGAATTGGCCAGGCATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTA GGCAGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCATC TTTACTAAAAATATAAAGTACATCTCTACTAAAAATACGAAAAAATTGGCTGGGCATGGT GGCGCACACCTGTAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGAATCTCTTGGACCTG GGAGGCGGAGGTTGCAATGAGCCGAGATCACGTCACTGCACTCCAGCTTGGGCAACAGAG CAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_002439 |
| Insert Size | 4500 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to be a perfect match to NM_002439.2. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002439.2, NP_002430.2 |
| RefSeq Size | 4645 bp |
| RefSeq ORF | 3414 bp |
| Locus ID | 4437 |
| UniProt ID | P20585 |
| Domains | MutS_V, MutS_I, MutS_III, MutS_II |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Colorectal cancer, Mismatch repair, Pathways in cancer |
| Gene Summary | The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC212391 | MSH3 (Myc-DDK-tagged)-Human mutS homolog 3 (E. coli) (MSH3) |
CNY 11,872.00 |
|
| RC212391L1 | Lenti ORF clone of Human mutS homolog 3 (E. coli) (MSH3), Myc-DDK-tagged |
CNY 14,272.00 |
|
| RC212391L2 | Lenti ORF clone of Human mutS homolog 3 (E. coli) (MSH3), mGFP tagged |
CNY 10,260.00 |
|
| RC212391L3 | Lenti ORF clone of Human mutS homolog 3 (E. coli) (MSH3), Myc-DDK-tagged |
CNY 14,272.00 |
|
| RC212391L4 | Lenti ORF clone of Human mutS homolog 3 (E. coli) (MSH3), mGFP tagged |
CNY 14,272.00 |
|
| RG212391 | MSH3 (tGFP-tagged) - Human mutS homolog 3 (E. coli) (MSH3) |
CNY 13,472.00 |
