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NUP98 (NM_139132) Human Untagged Clone
CAT＃: SC309528
NUP98 (untagged)-Human nucleoporin 98kDa (NUP98), transcript variant 4
CNY 33,160.00
货期*
8周
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ADIR2; NUP96; Nup98-96; NUP196 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_139132, the custom clone sequence may differ by one or more nucleotides
ATGTTTAACAAATCATTTGGAACACCCTTTGGGGGTGGCACAGGTGGCTTTGGCACAACT TCAACATTTGGACAGAATACTGGCTTTGGCACTACTAGTGGAGGGGCATTTGGAACATCT GCATTTGGTTCTAGCAACAATACTGGAGGCCTCTTTGGAAATTCACAGACTAAACCAGGA GGATTGTTTGGAACCAGTTCATTTAGCCAGCCAGCTACCTCCACAAGCACTGGCTTTGGG TTTGGTACGTCAACAGGAACAGCAAATACCTTGTTTGGAACTGCAAGCACAGGGACCAGT CTCTTCTCATCCCAAAACAATGCCTTTGCACAAAATAAACCAACTGGCTTTGGCAATTTT GGAACCAGTACTAGCAGTGGAGGACTCTTTGGAACCACAAATACCACCTCTAATCCTTTT GGCAGCACATCTGGCTCCCTCTTTGGGCCAAGTAGTTTTACAGCTGCTCCTACTGGGACT ACTATTAAATTTAACCCTCCAACTGGTACAGATACTATGGTCAAAGCTGGAGTTAGCACT AACATAAGTACCAAGCACCAGTGTATTACTGCTATGAAAGAATATGAAAGCAAGTCACTA GAGGAACTTCGTTTAGAGGATTATCAGGCTAACAGGAAGGGCCCACAGAACCAGGTGGGA GCAGGTACCACAACTGGCTTGTTTGGGTCTTCTCCAGCCACTTCCAGCGCAACAGGACTC TTCAGCTCCTCCACCACTAATTCAGGCTTTGCATATGGTCAGAACAAAACTGCCTTTGGA ACTAGTACAACTGGATTTGGAACAAATCCAGGTGGTCTCTTTGGCCAACAGAATCAGCAG ACTACCAGCCTCTTCAGCAAACCATTTGGCCAGGCTACAACCACCCAGAACACTGGCTTT TCCTTTGGTAATACCAGCACCATAGGACAGCCAAGCACCAACACCATGGGATTATTTGGA GTAACCCAAGCCTCACAGCCTGGAGGTCTTTTTGGGACAGCTACAAACACCAGCACTGGG ACAGCATTTGGAACAGGAACAGGTCTCTTTGGGCAGACCAATACTGGATTTGGTGCTGTT GGTTCGACCCTGTTTGGCAATAACAAGCTTACTACATTTGGAAGCAGCACAACCAGTGCA CCTTCATTTGGTACAACCAGTGGCGGGCTCTTTGGTTTTGGCACAAATACCAGTGGGAAT AGTATTTTTGGAAGTAAACCAGCACCTGGGACTCTTGGAACTGGGCTTGGTGCAGGATTT GGAACAGCTCTTGGTGCTGGACAGGCATCTTTGTTTGGGAACAACCAACCTAAGATTGGA GGGCCTCTTGGTACAGGAGCCTTTGGGGCCCCTGGATTTAATACTACGACAGCCACTTTG GGCTTTGGAGCCCCCCAGGCCCCAGTAGCTTTGACAGATCCAAATGCTTCTGCTGCCCAG CAGGCTGTTCTCCAGCAGCACATCAATAGTCTAACATACTCACCTTTTGGAGACTCTCCT CTCTTCCGGAATCCGATGTCAGACCCTAAGAAGAAGGAAGAGAGATTGAAACCAACAAAT CCAGCAGCCCAGAAGGCTCTTACTACACCTACTCATTATAAACTGACACCCCGCCCTGCC ACTAGAGTCCGGCCAAAGGCTTTACAAACAACAGGCACAGCCAAGTCACATCTCTTTGAT GGGCTGGATGACGATGAACCATCCCTAGCCAATGGAGCATTCATGCCCAAGAAGAGCATT AAGAAGTTGGTTTTGAAGAACCTTAATAATAGCAATCTCTTTTCTCCTGTTAATCGTGAT TCAGAAAATCTAGCTTCACCATCTGAATATCCAGAAAATGGAGAGAGATTTAGTTTCCTA AGCAAACCTGTTGATGAGAATCACCAGCAGGATGGAGATGAAGATTCCCTTGTTTCACAT TTTTATACTAACCCTATTGCCAAACCTATTCCTCAAACCCCAGAAAGTGCTGGAAATAAA CACAGCAACAGCAACAGTGTGGATGATACCATTGTTGCATTAAACATGCGTGCTGCTTTG CGAAATGGGCTGGAAGGAAGCAGTGAAGAAACGTCTTTTCATGATGAGTCACTTCAGGAT GACCGAGAAGAAATAGAAAATAATTCTTACCATATGCACCCAGCAGGTATTATTCTCACT AAGGTTGGTTACTATACTATTCCATCTATGGATGACCTTGCTAAAATTACCAATGAAAAA GGAGAGTGCATTGTCTCTGATTTCACTATTGGTCGGAAAGGTTATGGTTCAATCTATTTT GAAGGAGATGTGAATTTGACAAATCTAAATTTGGATGATATTGTGCATATCCGGAGGAAA GAAGTAGTTGTCTACTTAGATGATAACCAAAAACCACCTGTGGGTGAAGGGCTAAATAGG AAGGCTGAAGTTACATTGGATGGAGTTTGGCCAACAGATAAAACATCTCGTTGTTTAATA AAGAGCCCAGATCGCCTTGCTGATATCAACTATGAAGGAAGATTGGAAGCAGTTTCAAGG AAACAGGGAGCTCAATTCAAAGAATACCGGCCTGAAACTGGTTCTTGGGTGTTTAAGGTC TCCCATTTTTCTAAGTATGGCCTTCAGGATTCTGATGAAGAGGAGGAGGAGCATCCGTCT AAAACTAGTACAAAGAAGTTGAAGACTGCTCCTTTGCCTCCTGCAAGCCAGACTACGCCC TTGCAGATGGCTCTTAATGGCAAACCTGCACCTCCACCTCAGAGCCAGAGCCCAGAGGTG GAGCAGTTAGGGAGGGTTGTGGAACTGGACAGTGACATGGTAGATATCACCCAGGAGCCA GTTTTGGATACCATGTTAGAAGAGAGCATGCCTGAGGATCAGGAACCTGTGTCTGCCTCA ACACATATTGCATCTTCACTGGGAATTAATCCACATGTCTTACAGATCATGAAAGCATCA TTGCTTACTGATGAAGAAGATGTAGATATGGCACTGGATCAACGCTTCAGTCGCCTGCCT TCCAAAGCAGATACTTCTCAAGAAATCTGTTCTCCCAGACTCCCCATTTCAGCATCCCAC TCGTCGAAAACTCGTTCACTAGTTGGTGGGTTACTACAATCAAAATTTACAAGTGGAGCT TTTCTTTCACCAAGTGTCTCTGTGCAAGAATGTCGTACTCCCAGAGCAGCATCTTTAATG AATATCCCATCCACATCCTCTTGGTCTGTCCCTCCACCCCTGACTTCTGTGTTCACAATG CCCAGCCCAGCCCCTGAGGTTCCGTTGAAAACAGTGGGTACACGTAGGCAACTAGGCCTA GTCCCTCGTGAAAAGTCTGTCACCTATGGCAAGGGAAAACTCTTGATGGACATGGCCCTA TTCATGGGACGCTCATTTCGTGTTGGTTGGGGCCCCAACTGGACTCTTGCTAATAGTGGA GAACAGCTGAATGGCTCTCATGAACTAGAAAATCATCAGATTGCCGATTCCATGGAGTTT GGATTCCTGCCCAATCCAGTAGCTGTTAAACCCCTAACTGAGTCCCCATTCAAAGTTCAC TTAGAAAAACTCAGTTTGAGACAAAGAAAGCCAGATGAAGACATGAAATTATATCAGACA CCTCTGGAGCTCAAATTAAAACACAGCACTGTCCATGTGGATGAACTGTGTCCTCTCATT GTCCCCAATCTGGGAGTTGCTGTCATTCATGACTATGCAGATTGGGTTAAAGAAGCATCA GGAGACTTACCAGAAGCACAAATTGTGAAGCACTGGAGCCTGACATGGACACTATGTGAA GCCCTATGGGGCCACCTGAAGGAGCTTGACAGCCAGCTAAATGAACCCCGTGAATACATT CAAATTCTGGAGCGAAGAAGAGCTTTCTCCCGCTGGCTATCCTGTACTGCCACACCTCAG ATTGAAGAGGAAGTCTCCTTAACCCAAAAAAACAGCCCTGTGGAGGCTGTATTCAGCTAC CTCACAGGCAAAAGGATCAGTGAGGCCTGCTCTCTGGCCCAGCAGTCAGGGGATCATCGT CTTGCTCTTCTTTTATCTCAGTTTGTGGGTAGCCAGTCAGTCCGGGAGCTGCTCACCATG CAGTTGGTGGACTGGCATCAGCTCCAAGCAGACTCCTTCATCCAGGATGAGAGACTGCGC ATCTTTGCTCTGTTGGCTGGAAAACCGGTGTGGCAGCTCTCAGAAAAGAAGCAAATAAAC GTGTGCTCCCAGTTGGATTGGAAACGCTCCCTGGCTATCCATCTTTGGTATTTGCTTCCA CCAACAGCCTCCATTTCTAGGGCGCTCAGCATGTATGAAGAAGCATTTCAGAATACCTCT GACAGTGACAGATATGCCTGCTCCCCACTTCCTTCGTATCTGGAGGGTTCTGGCTGTGTG ATAGCGGAGGAGCAAAACTCACAGACACCACTTCGAGATGTCTGCTTTCACCTTCTAAAA CTCTACAGTGACAGCATACGTGAGAAGGCTGTTCGAGAGCTGCTTACCCGGCACTGCCAG CTGTTGGAGACCCCTGAATCTTGGGCTAAAGAGACTTTCCTTACCCAGAAGCTCCGTGTA CCTGCCAAATGGATCCACGAGGCCAAAGCTGTGCGAGCACACATGGAATCTGACAAGCAC TTAGAGGCCCTTTGCTTATTTAAGGCTGAGCACTGGAACCGCTGCCACAAGCTCATCATC CGACACTTAGCTTCTGATGCCATCATTAATGAGAACTATGACTACCTGAAGGGGTTCTTG GAAGACCTGGCACCTCCAGAGCGCAGCAGCCTAATTCAGGATTGGGAAACATCTGGGCTT GTTTACCTGGACTATATTAGAGTCATTGAAATGCTCCGCCATATACAGCAGGTGGATTGC TCAGGTAATGACCTGGAGCAGTTACACATCAAAGTGACTTCACTGTGCAGTCGGATAGAG CAGATTCAGTGTTACAGTGCTAAAGATCGCCTGGCTCAGTCAGACATGGCCAAACGTGTA GCCAACCTGCTGCGCGTGGTGCTGAGTCTGCATCATCCTCCTGATAGAACCTCCGACTCA ACACCAGACCCTCAGCGAGTCCCTTTGCGCCTCTTGGCTCCCCACATTGGCCGGCTTCCC ATGCCTGAGGACTATGCCATGGACGAACTGCGCAGCCTTACCCAGTCCTATCTGCGAGAA CTGGCTGTTGGGAGCCTGTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_139132 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_139132.2, NP_624358.2 |
| RefSeq Size | 6628 bp |
| RefSeq ORF | 5181 bp |
| Locus ID | 4928 |
| UniProt ID | P52948 |
| Protein Families | Druggable Genome |
| Gene Summary | Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016] Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) has the same N- and C-termini, but is shorter than isoform 1. This isoform (4) may undergo proteolytic processing similar to that of isoform 1. |
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