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NOTCH3 (NM_000435) Human Untagged Clone
CAT＃: SC309060
NOTCH3 (untagged)-Human notch 3 (NOTCH3)
CNY 22,992.00
货期*
现货
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CADASIL; CADASIL1; CASIL; IMF2; LMNS |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000435 edited
CGGCGCGGAGGCTGGCCCGGGACGCGCCCGGAGCCCAGGGAAGGAGGGAGGAGGGGAGGG TCGCGGCCGGCCGCCATGGGGCCGGGGGCCCGTGGCCGCCGCCGCCGCCGTCGCCCGATG TCGCCGCCACCGCCACCGCCACCCGTGCGGGCGCTGCCCCTGCTGCTGCTRCTAGCGGGG CCGGGGGCTGCAGCCCCCCCTTGCCTGGACGGAAGCCCGTGTGCAAATGGAGGTCGTTGC ACCCAGCTGCCCTCCCGGGAGGCTGCCTGCCTGTGCCCGCCTGGCTGGGTGGGTGAGCGG TGTCAGCTGGAGGACCCCTGTCACTCAGGCCCCTGTGCTGGCCGTGGTGTCTGCCAGAGT TCAGTGGTGGCTGGCACTGCCCGATTCTCATGCCGGTGCCCCCGTGGCTTCCGAGGCCCT GACTGCTCCCTGCCAGATCCCTGCCTCAGCAGCCCTTGTGCCCACGGTGCCCGCTGCTCA GTGGGGCCCGATGGACGCTTCCTCTGCTCCTGCCCACCTGGCTACCAGGGCCGCAGCTGC CGAAGCGACGTGGATGAGTGCCGGGTGGGTGAGCCCTGCCGCCATGGTGGCACCTGCCTC AACACACCTGGCTCCTTCCGCTGCCAGTGTCCAGCTGGCTACACAGGGCCACTATGTGAG AACCCCGCGGTGCCCTGTGCGCCCTCACCATGCCGTAACGGGGGCACCTGCAGGCAGAGT GGCGACCTCACTTACGACTGTGCCTGTCTTCCTGGGTTTGAGGGTCAGAATTGTGAAGTG AACGTGGACGACTGTCCAGGACACCGATGTCTCAATGGGGGGACATGCGTGGATGGCGTC AACACCTATAACTGCCAGTGCCCTCCTGAGTGGACAGGCCAGTTCTGCACGGAGGACGTG GATGAGTGTCAGCTGCAGCCCAACGCCTGCCACAATGGGGGTACCTGCTTCAACACGCTG GGTGGCCACAGCTGCGTGTGTGTCAATGGCTGGACAGGCGAGAGCTGCAGTCAGAATATC GATGACTGTGCCACAGCCGTGTGCTTCCATGGGGCCACCTGCCATGACCGCGTGGCTTCT TTCTACTGTGCCTGCCCCATGGGCAAGACTGGCCTCCTGTGTCACCTGGATGACGCCTGT GTCAGCAACCCCTGCCACGAGGATGCTATCTGTGACACAAATCCGGTGAACGGCCGGGCC ATTTGCACCTGTCCTCCCGGCTTCACGGGTGGGGCATGTGACCAGGATGTGGACGAGTGC TCTATCGGCGCCAACCCCTGCGAGCACTTGGGCAGGTGCGTGAACACGCAGGGCTCCTTC CTGTGCCAGTGCGGTCGTGGCTACACTGGACCTCGCTGTGAGACCGATGTCAACGAGTGT CTGTCGGGGCCCTGCCGAAACCAGGCCACGTGCCTCGACCGCATAGGCCAGTTCACCTGT ATCTGTATGGCAGGCTTCACAGGAACCTATTGCGAGGTGGACATTGACGAGTGTCAGAGT AGCCCCTGTGTCAACGGTGGGGTCTGCAAGGACCGAGTCAATGGCTTCAGCTGCACCTGC CCCTCGGGCTTCAGCGGCTCCACGTGTCAGCTGGACGTGGACGAATGCGCCAGCACGCCC TGCAGGAATGGCGCCAAATGCGTGGACCAGCCCGATGGCTACGAGTGCCGCTGTGCCGAG GGCTTTGAGGGCACGCTGTGTGATCGCAACGTGGACGACTGCTCCCCTGACCCATGCCAC CATGGTCGCTGCGTGGATGGCATCGCCAGCTTCTCATGTGCCTGTGCTCCTGGCTACACG GGCACACGCTGCGAGAGCCAGGTGGACGAATGCCGCAGCCAGCCCTGCCGCCATGGCGGC AAATGCCTAGACCTGGTGGACAAGTACCTCTGCCGCTGCCCTTCTGGGACCACAGGTGTG AACTGCGAAGTGAACATTGACGACTGTGCCAGCAACCCCTGCACCTTTGGAGTCTGCCGT GATGGCATCAACCGCTACGACTGTGTCTGCCAACCTGGCTTCACAGGGCCCCTTTGTAAC GTGGAGATCAATGAGTGTGCTTCCAGCCCATGCGGCGAGGGAGGTTCCTGTGTGGATGGG GAAAATGGCTTCCGCTGCCTCTGCCCGCCTGGCTCCTTGCCCCCACTCTGCCTCCCCCCG AGCCATCCCTGTGCCCATGAGCCCTGCAGTCACGGCATCTGCTATGATGCACCTGGCGGG TTCCGCTGTGTGTGTGAGCCTGGCTGGAGTGGCCCCCGCTGCAGCCAGAGCCTGGCCCGA GACGCCTGTGAGTCCCAGCCGTGCAGGGCCGGTGGGACATGCAGCAGCGATGGAATGGGT TTCCACTGCACCTGCCCGCCTGGTGTCCAGGGACGTCAGTGTGAACTCCTCTCCCCCTGC ACCCCGAACCCCTGTGAGCATGGGGGCCGCTGCGAGTCTGCCCCTGGCCAGCTGCCTGTC TGCTCCTGCCCCCAGGGCTGGCAAGGCCCACGATGCCAGCAGGATGTGGACGAGTGTGCT GGCCCCGCACCCTGTGGCCCTCATGGTATCTGCACCAACCTGGCAGGGAGTTTCAGCTGC ACCTGCCATGGAGGGTACACTGGCCCTTCCTGTGATCAGGACATCAATGACTGTGACCCC AACCCATGCCTGAACGGTGGCTCGTGCCAAGACGGCGTGGGCTCCTTTTCCTGCTCCTGC CTCCCTGGTTTCGCCGGCCCACGATGCGCCCGCGATGTGGATGAGTGCCTGAGCAACCCC TGCGGCCCGGGCACCTGTACCGACCACGTGGCCTCCTTCACCTGCACCTGCCCGCCGGGC TACGGAGGCTTCCACTGCGAACAGGACCTGCCCGACTGCAGCCCCAGCTCCTGCTTCAAT GGCGGGACCTGTGTGGACGGCGTGAACTCGTTCAGCTGCCTGTGCCGTCCCGGCTACACA GGAGCCCACTGCCAACATGAGGCAGACCCCTGCCTCTCGCGGCCCTGCCTACACGGGGGC GTCTGCAGCGCCGCCCACCCTGGCTTCCGCTGCACCTGCCTCGAGAGCTTCACGGGCCCG CAGTGCCAGACGCTGGTGGATTGGTGCAGCCGCCAGCCTTGTCAAAACGGGGGTCGCTGC GTCCAGACTGGGGCCTATTGCCTTTGTCCCCCTGGATGGAGCGGACGCCTCTGTGACATC CGAAGCTTGCCCTGCAGGGAGGCCGCAGCCCAGATCGGGGTGCGGCTGGAGCAGCTGTGT CAGGCGGGTGGGCAGTGTGTGGATGAAGACAGCTCCCACTACTGCGTGTGCCCAGAGGGC CGTACTGGTAGCCACTGTGAGCAGGAGGTGGACCCCTGCTTGGCCCAGCCCTGCCAGCAT GGGGGGACCTGCCGTGGCTATATGGGGGGCTACATGTGTGAGTGTCTTCCTGGCTACAAT GGTGATAACTGTGAGGACGACGTGGACGAGTGTGCCTCCCAGCCCTGCCAGCACGGGGGT TCATGCATTGACCTCGTGGCCCGCTATCTCTGCTCCTGTCCCCCAGGAACGCTGGGGGTG CTCTGCGAGATTAATGAGGATGACTGCGGCCCAGGCCCACCGCTGGACTCAGGGCCCCGG TGCCTACACAATGGCACCTGCGTGGACCTGGTGGGTGGTTTCCGCTGCACCTGTCCCCCA GGATACACTGGTTTGCGCTGCGAGGCAGACATCAATGAGTGTCGCTCAGGTGCCTGCCAC GCGGCACACACCCGGGACTGCCTGCAGGACCCAGGCGGAGGTTTCCGTTGCCTTTGTCAT GCTGGCTTCTCAGGTCCTCGCTGTCAGACTGTCCTGTCTCCCTGCGAGTCCCAGCCATGC CAGCATGGAGGCCAGTGCCGTCCTAGCCCGGGTCCTGGGGGTGGGCTGACCTTCACCTGT CACTGTGCCCAGCCGTTCTGGGGTCCGCGTTGCGAGCGGGTGGCGCGCTCCTGCCGGGAG CTGCAGTGCCCGGTGGGCGTCCCATGCCAGCAGACGCCCCGCGGGCCGCGCTGCGCCTGC CCCCCAGGGTTGTCGGGACCCTCCTGCCGCAGCTTCCCGGGGTCGCCGCCGGGGGCCAGC AACGCCAGCTGCGCGGCCGCCCCCTGTCTCCACGGGGGCTCCTGCCGCCCCGCGCCGCTC GCGCCCTTCTTCCGCTGCGCTTGCGCGCAGGGCTGGACCGGGCCGCGCTGCGAGGCGCCC GCCGCGGCACCCGAGGTCTCGGAGGAGCCGCGGTGCCCGCGCGCCGCCTGCCAGGCCAAG CGCGGGGACCAGCGCTGCGACCGCGAGTGCAACAGCCCAGGCTGCGGCTGGGACGGCGGC GACTGCTCGCTGAGCGTGGGCGACCCCTGGCGGCAATGCGAGGCGCTGCAGTGCTGGCGC CTCTTCAACAACAGCCGCTGCGACCCCGCCTGCAGCTCGCCCGCCTGCCTCTACGACAAC TTCGACTGCCACGCCGGTGGCCGCGAGCGCACTTGCAACCCGGTGTACGAGAAGTACTGC GCCGACCACTTTGCCGACGGCCGCTGCGACCAGGGCTGCAACACGGAGGAGTGCGGCTGG GATGGGCTGGATTGTGCCAGCGAGGTGCCGGCCCTGCTGGCCCGCGGCGTGCTGGTGCTC ACAGTGCTGCTGCCGCCGGAGGAGCTACTGCGTTCCAGCGCCGACTTTCTGCAGCGGCTC AGCGCCATCCTGCGCACCTCGCTGCGCTTCCGCCTGGACGCGCACGGCCAGGCCATGGTC TTCCCTTACCACCGGCCTAGTCCTGGCTCCGAACCCCGGGCCCGTCGGGAGCTGGCCCCC GAGGTGATCGGCTCGGTAGTAATGCTGGAGATTGACAACCGGCTCTGCCTGCAGTCGCCT GAGAATGATCACTGCTTCCCCGATGCCCAGAGCGCCGCTGACTACCTGGGAGCGTTGTCA GCGGTGGAGCGCCTGGACTTCCCGTACCCACTGCGGGACGTGCGGGGGGAGCCGCTGGAG CCTCCAGAACCCAGCGTCCCGCTGCTGCCACTGCTAGTGGCGGGCGCTGTCTTGCTGCTG GTCATTCTCGTCCTGGGTGTCATGGTGGCCCGGCGCAAGCGCGAGCACAGCACCCTCTGG TTCCCTGAGGGCTTCTCACTGCACAAGGACGTGGCCTCTGGTCACAAGGGCCGGCGGGAA CCCGTGGGCCAGGACGCGCTGGGCATGAAGAACATGGCCAAGGGTGAGAGCCTGATGGGG GAGGTGGCCACAGACTGGATGGACACAGAGTGCCCAGAGGCCAAGCGGCTAAAGGTAGAG GAGCCAGGCATGGGGGCTGAGGAGGCTGTGGATTGCCGTCAGTGGACTCAACACCATCTG GTTGCTGCTGACATCCGCGTGGCACCAGCCATGGCACTGACACCACCACAGGGCGACGCA GATGCTGATGGCATGGATGTCAATGTGCGTGGCCCAGATGGCTTCACCCCGCTAATGCTG GCTTCCTTCTGTGGGGGGGCTCTGGAGCCAATGCCAACTGAAGAGGATGAGGCAGATGAC ACATCAGCTAGCATCATCTCCGACCTGATCTGCCAGGGGGCTCAGCTTGGGGCACGGACT GACCGTACTGGCGAGACTGCTTTGCACCTGGCTGCCCGTTATGCCCGTGCTGATGCAGCC AAGCGGCTGCTGGATGCTGGGGCAGACACCAATGCCCAGGACCACTCAGGCCGCACTCCC CTGCACACAGCTGTCACAGCCGATGCCCAGGGTGTCTTCCAGATTCTCATCCGAAACCGC TCTACAGACTTGGATGCCCGCATGGCAGATGGCTCAACGGCACTGATCCTGGCGGCCCGC CTGGCAGTAGAGGGCATGGTGGAAGAGCTCATCGCCAGCCATGCTGATGTCAATGCTGTG GATGAGCTTGGGAAATCAGCCTTACACTGGGCTGCGGCTGTGAACAACGTGGAAGCCACT TTGGCCCTGCTCAAAAATGGAGCCAATAAGGACATGCAGGATAGCAAGGAGGAGACCCCC CTATTCCTGGCCGCCCGCGAGGGCAGCTATGAGGCTGCCAAGCTGCTGTTGGACCACTTT GCCAACCGTGAGATCACCGACCACCTGGACAGGCTGCCGCGGGACGTAGCCCAGGAGAGA CTGCACCAGGACATCGTGCGCTTGCTGGATCAACCCAGTGGGCCCCGCAGCCCCCCCGGT CCCCACGGCCTGGGGCCTCTGCTCTGTCCTCCAGGGGCCTTCCTCCCTGGCCTCAAAGCG GCACAGTCGGGGTCCAAGAAGAGCAGGAGGCCCCCCGGGAAGGCGGGGCTGGGGCCGCAG GGGCCCCGGGGGCGGGGCAAGAAGCTGACGCTGGCCTGCCCGGGCCCCCTGGCTGACAGC TCGGTCACGCTGTCGCCCGTGGACTCGCTGGACTCCCCGCGGCCTTTCGGTGGGCCCCCT GCTTCCCCTGGTGGCTTCCCCCTTGAGGGGCCCTATGCAGCTGCCACTGCCACTGCAGTG TCTCTGGCACAGCTTGGTGGCCCAGGCCGGGCGGGTCTAGGGCGCCAGCCCCCTGGAGGA TGTGTACTCAGCCTGGGCCTGCTGAACCCTGTGGCTGTGCCCCTCGATTGGGCCCGGCTG CCCCCACCTGCCCCTCCAGGCCCCTCGTTCCTGCTGCCACTGGCGCCGGGACCCCAGCTG CTCAACCCAGGGACCCCCGTCTCCCCGCAGGAGCGGCCCCCGCCTTACCTGGCAGTCCCA GGACATGGCGAGGAGTACCCGGTGGCTGGGGCACACAGCAGCCCCCCAAAGGCCCGCTTC CTGCGGGTTCCCAGTGAGCACCCTTACCTGACCCCATCCCCCGAATCCCCTGAGCACTGG GCCAGCCCCTCACCTCCCTCCCTCTCAGACTGGTCCGAATCCACGCCTAGCCCAGCCACT GCCACTGGGGCCATGGCCACCACCACTGGGGCACTGCCTGCCCAGCCACTTCCCTTGTCT GTTCCCAGCTCCCTTGCTCAGGCCCAGACCCAGCTGGGGCCCCAGCCGGAAGTTACCCCC AAGAGGCAAGTGTTGGCCTGAGACGCTCGTCAGTTCTTAGATCTTGGGGGCCTAAAGAGA CCCCCGTCCTGCCTCCTTTCTTTCTCTGTCTCTTCCTTCCTTTTAGTCTTTTTCATCCTC TTCTCTTTCCACCAACCCTCCTGCATCCTTGCCTTGCAGCGTGACCGAGATAGGTCATCA GCCCAGGGCTTCAGTCTTCCTTTATTTATAATGGGTGGGGGCTACCACCCACCCTCTCAG TCTTGTGAAGAGTCTGGGACCTCCTTCTTCCCCACTTCTCTCTTCCCTCATTCCTTTCTC TCTCCTTCTGGCCTCTCATTTCCTTACACTCTGACATGAATGAATTATTATTATTTTTCT TTTTCTTTTTTTTTTTACATTTTGTATAGAAACAAATTCATTTAAACAAACTTATTATTA TTATTTTTTACAAAATATATATATGGAGATGCTCCCTCCCCCTGTGAACCCCCCAGTGCC CCCGTGGGGCTGAGTCTGTGGGCCCATTCGGCCAAGCTGGATTCTGTGTACCTAGTACAC AGGCATGACTGGGATCCCGTGTACCGAGTACACGACCCAGGTATGTACCAAGTAGGCACC CTTGGGCGCACCCACTGGGGCCAGGGGTCGGGGGAGTGTTGGGAGCCTCCTCCCCACCCC ACCTCCCTCACTTCACTGCATTCCAGATTGGACATGTTCCATAGCCTTGCTGGGGAAGGG CCCACTGCCAACTCCCTCTGCCCCAGCCCCACCCTTGGCCATCTCCCTTTGGGAACTAGG GGGCTGCTGGTGGGAAATGGGAGCCAGGGCAGATGTATGCATTCCTTTATGTCCCTGTAA ATGTGGGACTACAAGAAGAGGAGCTGCCTGAGTGGTACTTTCTCTTCCTGGTAATCCTCT GGCCCAGCCTTATGGCAGAATAGAGGTATTTTTAGGCTATTTTTGTAATATGGCTTCTGG TCAAAATCCCTGTGTAGCTGAATTCCCAAGCCCTGCATTGTACAGCCCCCCACTCCCCTC ACCACCTAATAAAGGAATAGTTAACACTCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_000435 unedited
NNNAAACGGGAACGTCAGTATTTGTAAACGACTCACTATAGGCGGCCGCGAAATCGGCAC CAGGCGGCGCGGAAGCTGGCCCGGGACGCGCCCGGAGCCCAAGGAAGAGGGAGGAGGGGA GGGTCGCGGCCGGCCGCCATGGGGCCGGGGGCCCGTGGCCGCCGCCGCCGCCGTCGCCCG ATGTCGCCGCCACCGCCACCGCCACCCGTGCGGGCGCTGCCCCTGCTGCTGCTACTAAGC GGGCCGGGGGGCTGCAGCCCCCCCCTTGCCTGGACNGAAGCCCGTGTGCAAATGGAAGTC GTTGCAACCAACTGCCCTCCCGGAAGCTGGCTGGCTGTGCCCCCTGGCTGGTTGGTTAAC CGGTACACTGAAAAAACCTGTAATAAGGCCCTGGCTTGCCTGGGGTTTGCCAAATTAAGG GGGGCTGGAATGCCCATATTAAGCCCGGGCCCCTGGGTTCCAAGACTTAAAGTTTCTGGC AAACCCGGTAAAAAACCTTTTGCCAAGGGGCCCTTTTAAAGGGGGCCAAGAAACTTTTTT GTTCTGGCACCTTGTATAAAGGCCAAATTCCCAAAAACTTTAAAAAACCCCCGGGGGAAA CCCTCCGCCAAATGGAAACATGTAAAAAAAAAGGGGTTTTTCGTGAAAAGTAAACGGGGA AAAAAGGGCCTTTTGGAAAAACCCCGGGGGCCCTGGGCCCCCCACAAAGCCTAAAAGGGG CCCCTGGCGAAAAAGGGCACCCCAAAAAAAAAGGGACCTTTTTCCGGGGTTTGGGGGAAA AAATGAAAAAAAAGGGGAAAATATTCCCAAC |
| Restriction Sites | Please inquire |
| ACCN | NM_000435 |
| Insert Size | 8200 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000435.1, NP_000426.1 |
| RefSeq Size | 8091 bp |
| RefSeq ORF | 6966 bp |
| Locus ID | 4854 |
| UniProt ID | Q9UM47 |
| Domains | NL, EGF_CA, ANK, EGF, EGF |
| Protein Families | Druggable Genome |
| Protein Pathways | Dorso-ventral axis formation, Notch signaling pathway |
| Gene Summary | This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC224711 | NOTCH3 (Myc-DDK-tagged)-Human notch 3 (NOTCH3) |
CNY 22,984.00 |
|
| RC224711L1 | Lenti ORF clone of Human notch 3 (NOTCH3), Myc-DDK-tagged |
CNY 25,384.00 |
|
| RG224711 | NOTCH3 (tGFP-tagged) - Human notch 3 (NOTCH3) |
CNY 24,584.00 |
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