ABCA2 (NM_212533) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	ABC2; IDPOGSA
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC308644 representing NM_212533. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGGGAGAAAAACGAGCCGCGTGCAGCAGGGGCCGCCTCGGTCCCCTGCCTGCTCCGCTCACGGCGAG CGTTCCTGGGGCCTCGAGTTTCCCCCCTTCCGCTGGCTGCTCGGAATCGCGGGACGGACCCACCTGGCC GCCCTGCCTCCCTTCCAGTGGGTCCTGGCCTTCGAGATCTTCATCCCCCTGGTGCTGTTCTTTATCCTG CTGGGGCTGCGACAGAAGAAGCCCACCATCTCCGTGAAGGAAGTCTCCTTCTACACAGCGGCGCCCCTG ACGTCTGCCGGCATCCTGCCTGTCATGCAATCGCTGTGCCCGGACGGCCAGCGAGACGAGTTCGGCTTC CTGCAGTACGCCAACTCCACGGTCACGCAGCTGCTTGAGCGCCTGGACCGCGTGGTGGAGGAAGGCAAC CTGTTTGACCCAGCGCGGCCCAGCCTGGGCTCAGAGCTCGAGGCCCTACGCCAGCATCTGGAGGCCCTC AGTGCGGGCCCGGGCACCTCGGGGAGCCACCTGGACAGATCCACAGTGTCTTCCTTCTCTCTGGACTCG GTGGCCAGAAACCCGCAGGAGCTCTGGCGTTTCCTGACGCAAAACTTGTCGCTGCCCAATAGCACGGCC CAAGCACTCTTGGCCGCCCGTGTGGACCCGCCCGAGGTCTACCACCTGCTCTTTGGTCCCTCATCTGCC CTGGATTCACAGTCTGGCCTCCACAAGGGTCAGGAGCCCTGGAGCCGCCTAGGGGGCAATCCCCTGTTC CGGATGGAGGAGCTGCTGCTGGCTCCTGCCCTCCTGGAGCAGCTCACCTGCACGCCGGGCTCGGGGGAG CTGGGCCGGATCCTCACTGTGCCTGAGAGTCAGAAGGGAGCCCTGCAGGGCTACCGGGATGCTGTCTGC AGTGGGCAGGCTGCTGCGCGTGCCAGGCGCTTCTCTGGGCTGTCTGCTGAGCTCCGGAACCAGCTGGAC GTGGCCAAGGTCTCCCAGCAGCTGGGCCTGGATGCCCCCAACGGCTCGGACTCCTCGCCACAGGCGCCA CCCCCACGGAGGCTGCAGGCGCTTCTGGGGGACCTGCTGGATGCCCAGAAGGTTCTGCAGGATGTGGAT GTCCTGTCGGCCCTGGCCCTGCTACTGCCCCAGGGTGCCTGCACTGGCCGGACCCCCGGACCCCCAGCC AGTGGTGCGGGTGGGGCGGCCAATGGCACTGGGGCAGGGGCAGTCATGGGCCCCAACGCCACCGCTGAG GAGGGCGCACCCTCTGCTGCAGCACTGGCCACCCCGGACACGCTGCAGGGCCAGTGCTCAGCCTTCGTA CAGCTCTGGGCCGGCCTGCAGCCCATCTTGTGTGGCAACAACCGCACCATTGAACCCGAGGCGCTGCGG CGGGGCAACATGAGCTCCCTGGGCTTCACGAGCAAGGAGCAGCGGAACCTGGGCCTCCTCGTGCACCTC ATGACCAGCAACCCCAAAATCCTGTACGCGCCTGCGGGCTCTGAGGTCGACCGCGTCATCCTCAAGGCC AACGAGACTTTTGCTTTTGTGGGCAACGTGACTCACTATGCCCAGGTCTGGCTCAACATCTCGGCGGAG ATCCGCAGCTTCCTGGAGCAGGGCAGGCTGCAGCAACACCTGCGCTGGCTGCAGCAGTATGTAGCAGAG CTGCGGCTGCACCCCGAGGCACTGAACCTGTCACTGGATGAGCTGCCGCCGGCCCTGAGACAGGACAAC TTCTCGCTGCCCAGTGGCATGGCCCTCCTGCAGCAGCTGGATACCATTGACAACGCGGCCTGCGGCTGG ATCCAGTTCATGTCCAAGGTGAGCGTGGACATCTTCAAGGGCTTCCCCGACGAGGAGAGCATTGTCAAC TACACCCTCAACCAGGCCTACCAGGACAACGTCACTGTTTTTGCCAGTGTGATCTTCCAGACCCGGAAG GACGGCTCGCTCCCGCCTCACGTGCACTACAAGATCCGCCAGAACTCCAGCTTCACCGAGAAAACCAAC GAGATCCGCCGCGCCTACTGGCGGCCTGGGCCCAATACTGGCGGCCGCTTCTACTTCCTCTACGGCTTC GTCTGGATCCAGGACATGATGGAGCGCGCCATCATCGACACTTTTGTGGGGCACGATGTGGTGGAGCCA GGCAGCTACGTGCAGATGTTCCCCTACCCCTGCTACACACGCGATGACTTCCTGTTTGTCATTGAGCAC ATGATGCCGCTGTGCATGGTGATCTCCTGGGTCTACTCCGTGGCCATGACCATCCAGCACATCGTGGCG GAGAAGGAGCACCGGCTCAAGGAGGTGATGAAGACCATGGGCCTGAACAACGCGGTGCACTGGGTGGCC TGGTTCATCACCGGCTTTGTGCAGCTGTCCATCTCCGTGACAGCACTCACCGCCATCCTGAAGTACGGC CAGGTGCTTATGCACAGCCACGTGGTCATCATCTGGCTCTTCCTGGCAGTCTACGCGGTGGCCACCATC ATGTTCTGCTTCCTGGTGTCTGTGCTGTACTCCAAGGCCAAGCTGGCCTCGGCCTGCGGTGGCATCATC TACTTCCTGAGCTACGTGCCCTACATGTACGTGGCGATCCGAGAGGAGGTGGCGCATGATAAGATCACG GCCTTCGAGAAGTGCATCGCGTCCCTCATGTCCACGACGGCCTTTGGTCTGGGCTCTAAGTACTTCGCG CTGTATGAGGTGGCCGGCGTGGGCATCCAGTGGCACACCTTCAGCCAGTCCCCGGTGGAGGGGGACGAC TTCAACTTGCTCCTGGCTGTCACCATGCTGATGGTGGACGCCGTGGTCTATGGCATCCTCACGTGGTAC ATTGAGGCTGTGCACCCAGGCATGTACGGGCTGCCCCGGCCCTGGTACTTCCCACTGCAGAAGTCCTAC TGGCTGGGCAGTGGGCGGACAGAAGCCTGGGAGTGGAGCTGGCCGTGGGCACGCACCCCCCGCCTCAGT GTCATGGAGGAGGACCAGGCCTGTGCCATGGAGAGCCGGCGCTTTGAGGAGACCCGTGGCATGGAGGAG GAGCCCACCCACCTGCCTCTGGTTGTCTGCGTGGACAAACTCACCAAGGTCTACAAGGACGACAAGAAG CTGGCCCTGAACAAGCTGAGCCTGAACCTCTACGAGAACCAGGTGGTCTCCTTCTTGGGCCACAACGGG GCGGGCAAGACCACCACCATGTCCATCCTGACCGGCCTGTTCCCTCCAACGTCGGGTTCCGCCACCATC TACGGGCACGACATCCGCACGGAGATGGATGAGATCCGCAAGAACCTGGGCATGTGCCCGCAGCACAAT GTGCTCTTTGACCGGCTCACGGTGGAGGAACACCTCTGGTTCTACTCACGGCTCAAGAGCATGGCTCAG GAGGAGATCCGCAGAGAGATGGACAAGATGATCGAGGACCTGGAGCTCTCCAACAAACGGCACTCACTG GTGCAGACATTGTCGGGTGGCATGAAGCGCAAGCTGTCCGTGGCCATCGCCTTCGTGGGCGGCTCTCGC GCCATCATCCTGGACGAGCCCACGGCGGGCGTGGACCCCTACGCGCGCCGCGCCATCTGGGACCTCATC CTGAAGTACAAGCCAGGCCGCACCATCCTTCTGTCCACCCACCACATGGATGAGGCTGACCTGCTTGGG GACCGCATTGCCATCATCTCCCATGGGAAGCTCAAGTGCTGCGGCTCCCCGCTCTTCCTCAAGGGCACC TATGGCGACGGGTACCGCCTCACGCTGGTCAAGCGGCCCGCCGAGCCGGGGGGCCCCCAAGAGCCAGGG CTGGCATCCAGCCCCCCAGGTCGGGCCCCGCTGAGCAGCTGCTCCGAGCTCCAGGTGTCCCAGTTCATC CGCAAGCATGTGGCCTCCTGCCTGCTGGTCTCAGACACAAGCACGGAGCTCTCCTACATCCTGCCCAGC GAGGCCGCCAAGAAGGGGGCTTTCGAGCGCCTCTTCCAGCACCTGGAGCGCAGCCTGGATGCACTGCAC CTCAGCAGCTTCGGGCTGATGGACACGACCCTGGAGGAAGTGTTCCTCAAGGTGTCGGAGGAGGATCAG TCGCTGGAGAACAGTGAGGCCGATGTGAAGGAGTCCAGGAAGGATGTGCTCCCTGGGGCGGAGGGCCCG GCGTCTGGGGAGGGTCACGCTGGCAATCTGGCCCGGTGCTCGGAGCTGACCCAGTCGCAGGCATCGCTG CAGTCGGCGTCATCTGTGGGCTCTGCCCGTGGCGACGAGGGAGCTGGCTACACCGACGTCTATGGCGAC TACCGCCCCCTCTTTGATAACCCACAGGACCCAGACAATGTCAGCCTGCAAGAGGTGGAGGCAGAGGCC CTGTCGAGGGTCGGCCAGGGCAGCCGCAAGCTGGACGGCGGGTGGCTGAAGGTGCGCCAGTTCCACGGG CTGCTGGTCAAACGCTTCCACTGCGCCCGCCGCAACTCCAAGGCACTCTTCTCCCAGATCTTGCTGCCA GCCTTCTTCGTCTGCGTGGCCATGACCGTGGCCCTGTCCGTCCCGGAGATTGGTGATCTGCCCCCGCTG GTCCTGTCACCTTCCCAGTACCACAACTACACCCAGCCCCGTGGCAATTTCATCCCCTACGCCAACGAG GAGCGCCGCGAGTACCGGCTGCGGCTATCGCCCGACGCCAGCCCCCAGCAGCTCGTGAGCACGTTCCGG CTGCCGTCGGGGGTGGGTGCCACCTGCGTGCTCAAGTCTCCCGCCAACGGCTCGCTGGGGCCCACGTTG AACCTGAGCAGCGGGGAGTCGCGCCTGCTGGCGGCTCGGTTCTTCGACAGCATGTGTCTGGAGTCCTTC ACACAGGGGCTGCCACTGTCCAATTTCGTGCCACCCCCACCCTCGCCCGCCCCATCTGACTCGCCAGCG TCCCCGGATGAGGACCTGCAGGCCTGGAACGTCTCCCTGCCGCCCACCGCTGGGCCAGAAATGTGGACG TCGGCACCCTCCCTGCCGCGCCTGGTACGGGAGCCCGTCCGCTGCACCTGCTCTGCGCAGGGCACCGGC TTCTCCTGCCCCAGCAGTGTGGGCGGGCACCCGCCCCAGATGCGGGTGGTCACAGGCGACATCCTGACC GACATCACCGGCCACAATGTCTCTGAGTACCTGCTCTTCACCTCCGACCGCTTCCGACTGCACCGGTAT GGGGCCATCACCTTTGGAAACGTCCTGAAGTCCATCCCAGCCTCATTTGGCACCAGGGCCCCACCCATG GTGCGGAAGATCGCGGTGCGCAGGGCTGCCCAGGTTTTCTACAACAACAAGGGCTATCACAGCATGCCC ACCTACCTCAACAGCCTCAACAACGCCATCCTGCGTGCCAACCTGCCCAAGAGCAAGGGCAACCCGGCG GCTTACGGCATCACCGTCACCAACCACCCCATGAATAAGACCAGCGCCAGCCTCTCCCTGGATTACCTG CTGCAGGGCACGGATGTCGTCATCGCCATCTTCATCATCGTGGCCATGTCCTTCGTGCCGGCCAGCTTC GTTGTCTTCCTCGTGGCCGAGAAGTCCACCAAGGCCAAGCACCTGCAGTTTGTCAGCGGCTGCAACCCC ATCATCTACTGGCTGGCGAACTACGTGTGGGACATGCTCAACTACCTGGTCCCCGCTACCTGCTGTGTC ATCATCCTGTTTGTGTTCGACCTGCCGGCCTACACGTCGCCCACCAACTTCCCTGCCGTCCTCTCCCTC TTCCTGCTCTATGGGTGGTCCATCACGCCCATCATGTACCCGGCCTCCTTCTGGTTCGAGGTCCCCAGC TCCGCCTACGTGTTCCTCATTGTCATCAATCTCTTCATCGGCATCACCGCCACCGTGGCCACCTTCCTG CTACAGCTCTTCGAGCACGACAAGGACCTGAAGGTTGTCAACAGTTACCTGAAAAGCTGCTTCCTCATT TTCCCCAACTACAACCTGGGCCACGGGCTCATGGAGATGGCCTACAACGAGTACATCAACGAGTACTAC GCCAAGATTGGCCAGTTTGACAAGATGAAGTCCCCGTTCGAGTGGGACATTGTCACCCGCGGACTGGTG GCCATGGCGGTTGAGGGCGTCGTGGGCTTCCTCCTGACCATCATGTGCCAGTACAACTTCCTGCGGCGG CCACAGCGCATGCCTGTGTCTACCAAGCCTGTGGAGGATGATGTGGACGTGGCCAGTGAGCGGCAGCGA GTGCTCCGGGGAGACGCCGACAATGACATGGTCAAGATTGAGAACCTGACCAAGGTCTACAAGTCCCGG AAGATTGGCCGTATCCTGGCCGTTGACCGCCTGTGCCTGGGTGTGCGTCCTGGCGAGTGCTTCGGGCTC CTGGGCGTCAACGGTGCGGGCAAGACCAGCACCTTCAAGATGCTGACCGGCGACGAGAGCACGACGGGG GGCGAGGCCTTCGTCAATGGACACAGCGTGCTGAAGGAGCTGCTCCAGGTGCAGCAGAGCCTCGGCTAC TGCCCGCAGTGTGACGCGCTGTTCGACGAGCTCACGGCCCGGGAGCACCTGCAGCTGTACACGCGGCTG CGTGGGATCTCCTGGAAGGACGAGGCCCGGGTGGTGAAGTGGGCTCTGGAGAAGCTGGAGCTGACCAAG TACGCAGACAAGCCGGCTGGCACCTACAGCGGCGGCAACAAGCGGAAGCTCTCCACGGCCATCGCCCTC ATTGGGTACCCAGCCTTCATCTTCCTGGACGAGCCCACCACAGGCATGGACCCCAAGGCCCGGCGCTTC CTCTGGAACCTCATCCTTGACCTCATCAAGACAGGGCGTTCAGTGGTGCTGACATCACACAGCATGGAG GAGTGCGAGGCGCTGTGCACGCGGCTGGCCATCATGGTGAACGGTCGCCTGCGGTGCCTGGGCAGCATC CAGCACCTGAAGAACCGGTTTGGAGATGGCTACATGATCACGGTGCGGACCAAGAGCAGCCAGAGTGTG AAGGACGTGGTGCGGTTCTTCAACCGCAACTTCCCGGAAGCCATGCTCAAGGAGCGGCACCACACAAAG GTGCAGTACCAGCTCAAGTCGGAGCACATCTCGCTGGCCCAGGTGTTCAGCAAGATGGAGCAGGTGTCT GGCGTGCTGGGCATCGAGGACTACTCGGTCAGCCAGACCACACTGGACAATGTGTTCGTGAACTTTGCC AAGAAGCAGAGTGACAACCTGGAGCAGCAGGAGACGGAGCCGCCATCCGCACTGCAGTCCCCTCTCGGC TGCTTGCTCAGCCTGCTCCGGCCCCGGTCTGCCCCCACGGAGCTCCGGGCACTTGTGGCAGACGAGCCC GAGGACCTGGACACGGAGGACGAGGGCCTCATCAGCTTCGAGGAGGAGCGGGCCCAGCTGTCCTTCAAC ACGGACACGCTCTGCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites	SgfI-MluI
ACCN	NM_212533
Insert Size	7401 bp
OTI Disclaimer	Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_212533.2
RefSeq Size	8163 bp
RefSeq ORF	7401 bp
Locus ID	20
UniProt ID	Q9BZC7
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	ABC transporters, Lysosome
MW	273 kDa
Gene Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is longer and has a distinct N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene.

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