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KCNQ4 (NM_172163) Human Untagged Clone
CAT＃: SC306729
KCNQ4 (untagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2
CNY 4,784.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DFNA2; DFNA2A; KV7.4 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_172163 edited
ATGGCCGAGGCCCCCCCGCGCCGCCTCGGCCTGGGTCCCCCGCCCGGGGACGCCCCCCGC GCGGAGCTAGTGGCGCTCACGGCCGTGCAGAGCGAACAGGGCGAGGCGGGCGGGGGCGGC TCCCCGCGCCGCCTCGGCCTCCTGGGCAGCCCCCTGCCGCCGGGCGCGCCCCTCCCTGGG CCGGGCTCCGGCTCGGGCTCCGCCTGCGGCCAGCGCTCCTCGGCCGCGCACAAGCGCTAC CGCCGCCTGCAGAACTGGGTCTACAACGTGCTGGAGCGGCCCCGCGGCTGGGCCTTCGTC TACCACGTCTTCATATTTTTGCTGGTCTTCAGCTGCCTGGTGCTGTCTGTGCTGTCCACT ATCCAGGAGCACCAGGAACTTGCCAACGAGTGTCTCCTCATCTTGGAATTCGTGATGATC GTGGTTTTCGGCTTGGAGTACATCGTCCGGGTCTGGTCCGCCGGATGCTGCTGCCGCTAC CGAGGATGGCAGGGTCGCTTCCGCTTTGCCAGAAAGCCCTTCTGTGTCATCGACTTCATC GTGTTCGTGGCCTCGGTGGCCGTCATCGCCGCGGGTACCCAGGGCAACATCTTCGCCACG TCCGCGCTGCGCAGCATGCGCTTCCTGCAGATCCTGCGCATGGTGCGCATGGACCGCCGC GGCGGCACCTGGAAGCTGCTGGGCTCAGTGGTCTACGCGCATAGCAAGGAGCTGATCACC GCCTGGTACATCGGGTTCCTGGTGCTCATCTTCGCCTCCTTCCTGGTCTACCTGGCTGAG AAGGACGCCAACTCCGACTTCTCCTCCTACGCCGACTCGCTCTGGTGGGGGACGATTACA TTGACAACCATCGGCTATGGTGACAAGACACCGCACACATGGCTGGGCAGGGTCCTGGCT GCTGGCTTCGCCTTACTGGGCATCTCTTTCTTTGCCCTGCCTGCCGGCATCCTAGGCTCC GGCTTTGCCCTGAAGGTCCAGGAGCAGCACCGGCAGAAGCACTTCGAGAAGCGGAGGATG CCGGCAGCCAACCTCATCCAGGCTGCCTGGCGCCTGTACTCCACCGATATGAGCCGGGCC TACCTGACAGCCACCTGGTACTACTATGACAGTATCCTCCCATCCTTCAGCAGCCGGATG GGCATCAAAGACCGCATCCGCATGGGCAGCTCCCAGCGGCGGACGGGTCCTTCCAAGCAG CATCTGGCACCTCCAACAATGCCCACCTCCCCAAGCAGCGAGCAGGTGGGTGAGGCCACC AGCCCCACCAAGGTGCAAAAGAGCTGGAGCTTCAATGACCGCACCCGCTTCCGGGCATCT CTGAGACTCAAACCCCGCACCTCTGCTGAGGATGCCCCCTCAGAGGAAGTAGCAGAGGAG AAGAGCTACCAGTGTGAGCTCACGGTGGACGACATCATGCCTGCTGTGAAGACAGTCATC CGCTCCATCAGGATTCTCAAGTTCCTGGTGGCCAAAAGGAAATTCAAGGAGACACTGCGA CCGTACGACGTGAAGGACGTCATTGAGCAGTACTCAGCAGGCCACCTGGACATGCTGGGC CGGATCAAGAGCCTGCAAACTCGGGTGGACCAAATTGTGGGTCGGGGGCCCGGGGACAGG AAGGCCCGGGAGAAGGGCGACAAGGGGCCCTCCGACGCGGAGGTGGTGGATGAAATCAGC ATGATGGGACGCGTGGTCAAGGTGGAGAAGCAGGTGCAGTCCATCGAGCACAAGCTGGAC CTGCTGTTGGGCTTCTATTCGCGCTGCCTGCGCTCTGGCACCTCGGCCAGCCTGGGCGCC GTGCAAGTGCCGCTGTTCGACCCCGACATCACCTCCGACTACCACAGCCCTGTGGACCAC GAGGACATCTCCGTCTCCGCACAGACGCTCAGCATCTCCCGCTCGGTCAGCACCAACATG GACTGA >OriGene 5' read for NM_172163 unedited
GTTCAGCATTTGTATACGACTCACTATAGGCGGCCGCGNATTCAGATCTGGTACCGATAT CAAGCTTATGGCCGAGGCCCCCCCGCGCCGCCTCGGCCTGGGTCCCCCGCCCGGGGACGC CCCCCGCGCGGAGCTAGTGGCGCTCACGGCCGTGCAGAGCGAACAGGGCGAGGCGGGCGG GGGCGGCTCCCCGCGCCGCCTCGGCCTCCTGGGCAGCCCCCTGCCGCCGGGCGCGCCCCT CCCTGGGCCGGGCTCCGGCTCGGGCTCCGCCTGCGGCCAGCGCTCCTCGGCCGCGCACAA GCGCTACCGCCGCCTGCANAACAGNNNNNACAACGNGCNGNNNCNNNNNNNNNNNNNAGA CCNNNNNCCACCACGNCCGACCAGAAAAGCNGGACNNCAACNGCCCGGAGCAGACAGAGC AGGACACNANCCNNNANCACCANNAACCCCCCCCCCNNNGNCCCCCCCCCCCGGAACCCN NGAAGATCGNGGNTTTCGGCTTGGAGTACATCGTCCGGGTCTGGTCCGCCGGATGCTGCT GCCGCTACCGAGGATGGCAGGGTCGCTTCCGCTTTGCCNNNNNNNCCNNNNNNNNNNNNN NACNNCNNCNNGNNCNTGGCCTCGGTGGCCGTCATCGCCGCGGGTACCCAAGGCAACATC TTCGCCACGTCCGCGCTGCGCAGCATGCGCTTCCTGCAGATCCTGCGCATGGTGCGCATG GACCGCCGCGGCGGCACCTGGAAGCTGCTGGGCTCAAAGGTCTACCCGCATTGCAAGGAG CTGATCACCCGCCTGTACATCGGGTTCCT >OriGene 3' read for NM_172163 unedited
CATTGGGGATGGCAACTTCCAGGGCAGGNAAAGCACTGGGGAGGGGTCACAGGNATGCCA CCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTCAGTCC ATGTTGGTGCTGACCGAGCGGGAGATGCTGAGCGTCTGTGCGGAGACGGAGATGTCCTCG TGGTCCACAGGGCTGTGGTAGTCGGAGGTGATGTCGGGGTCGAACAGCGGCACTTGCACG GCGCCCAGGCTGGCCGAGGTGCCAGAGCGCAGGCAGCGCGAATAGAAGCCCAACAGCAGG TCCAGCTTGTGCTCGATGGACTGCACCTGCTTCTCCACCTTGACCACNCNTCCCATCATG CTNATTTCATCCACCACCTCCNCGTCGGAGGGCCCCTTGTCGCCCTTCTCCCGGGCCTTC CTGTCCCCGGGCCCCCGACCCACAATTTGNTCCCCCCNAGTTTGCAGGCTCTTGATCCGG CCCAGCATGTCCAGGTGGCCTGCTGAGTACTGCTCAATGACGTCCTTCACGTCGTACGGT CGCAGTGTCTCCTTGAATTTCCTTTTGGCCACCAGGAACTTGANAATCCTGNNGGANCNN NNNACTGGCTTCACAGCAGGCATGATGTCGTCCACCGTGAGCTCACACTGGTAGCTCTTC TCCTCTGCTACTTCCTCTGAGGGGGCATCCTCAGCAGAGGTGCGGGGTTTGAGTCTCAGA GATGCCCGGAAGCGGGTGCGGTCATTGAAGCTCCAGCTCTTTTGCACCTTGGTGGGGCTG GTGGCCTCACCCACCTGCTCGCTGCTTGGGGAGGT |
| Restriction Sites | Please inquire |
| ACCN | NM_172163 |
| Insert Size | 1900 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_172163.1, NP_751895.1 |
| RefSeq Size | 2173 bp |
| RefSeq ORF | 1926 bp |
| Locus ID | 9132 |
| UniProt ID | P56696 |
| Protein Families | Druggable Genome, Ion Channels: Potassium, Transmembrane |
| Gene Summary | The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. There are no publicly available transcripts supporting this variant; it is represented based on data in PMID:10025409. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
KCNQ5/Kv7.5 potassium channel expression and subcellular localization in primate retinal pigment epithelium and neural retina
,Xiaoming Zhang, Dongli Yang, and Bret A. Hughes,
Am J Physiol Cell Physiol, Nov 2011; 301: C1017 - C1026.
[KCNQ4]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213421 | KCNQ4 (Myc-DDK-tagged)-Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2 |
CNY 4,776.00 |
|
| RC213421L3 | Lenti ORF clone of Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC213421L4 | Lenti ORF clone of Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
| RG213421 | KCNQ4 (tGFP-tagged) - Human potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4), transcript variant 2 |
CNY 4,370.00 |
