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Cezanne (OTUD7B) (NM_020205) Human Untagged Clone
CAT＃: SC304721
OTUD7B (untagged)-Human OTU domain containing 7B (OTUD7B)
CNY 7,220.00
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CEZANNE; ZA20D1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC304721 representing NM_020205.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGACCCTGGACATGGATGCTGTTCTGTCAGATTTTGTCCGTTCCACAGGAGCAGAGCCAGGGCTAGCG CGAGATCTCCTAGAAGGAAAGAATTGGGATGTGAATGCCGCCCTCAGTGATTTTGAACAGCTACGTCAA GTCCATGCTGGAAACCTACCCCCATCCTTTAGTGAGGGGAGTGGTGGCTCCAGGACCCCTGAAAAAGGG TTTTCTGACAGAGAGCCTACTCGCCCTCCCCGACCCATCCTCCAGCGGCAGGATGACATCGTTCAAGAA AAACGCCTGTCTAGGGGCATCTCCCACGCCAGCTCCAGCATTGTTTCCCTGGCCCGGTCCCATGTCTCC TCCAATGGTGGGGGTGGGGGGAGCAATGAGCACCCCCTGGAAATGCCCATCTGTGCCTTCCAGCTTCCA GATCTCACTGTATACAATGAAGACTTCCGCAGCTTCATAGAGAGAGACCTCATTGAGCAGTCCATGCTG GTTGCCTTGGAACAGGCAGGGCGTTTGAACTGGTGGGTGAGTGTGGATCCCACCTCTCAGAGGCTGCTT CCTTTGGCAACTACTGGAGATGGGAACTGCCTCCTGCATGCAGCCTCCCTTGGAATGTGGGGTTTCCAT GATCGGGACTTGATGCTGCGGAAAGCTTTGTATGCACTGATGGAGAAGGGAGTTGAGAAGGAAGCGTTG AAAAGGCGCTGGAGGTGGCAGCAGACACAGCAGAATAAAGAGTCAGGGCTGGTATACACAGAAGATGAA TGGCAGAAGGAGTGGAATGAACTGATCAAGCTTGCCTCAAGTGAACCCCGAATGCATCTAGGTACCAAT GGAGCCAACTGTGGTGGGGTGGAGAGTTCTGAGGAGCCTGTATATGAGAGCCTTGAAGAGTTTCACGTC TTTGTCCTTGCTCATGTGCTTAGGAGGCCCATAGTCGTCGTGGCAGACACCATGCTGAGGGACTCCGGA GGGGAAGCATTTGCCCCTATTCCCTTTGGAGGAATCTATCTGCCTTTGGAGGTCCCAGCCAGCCAGTGT CACCGCTCCCCTCTGGTGCTCGCCTATGATCAGGCCCACTTTTCTGCACTCGTGTCCATGGAGCAGAAG GAGAATACCAAGGAACAAGCTGTGATCCCACTTACAGATTCAGAGTATAAGCTGCTGCCCTTGCACTTT GCTGTGGACCCTGGAAAGGGCTGGGAGTGGGGCAAAGATGATAGTGACAATGTCCGATTGGCCAGTGTA ATTCTGTCCCTAGAGGTCAAATTGCATCTGCTGCATAGCTACATGAATGTGAAGTGGATCCCACTGTCC TCTGATGCACAGGCTCCTCTGGCCCAGCCTGAGTCCCCCACCGCCTCAGCTGGAGATGAGCCCCGGTCC ACTCCTGAGTCTGGAGACTCAGACAAGGAGTCAGTTGGCAGCAGTTCCACCAGCAACGAGGGCGGCCGG CGGAAGGAGAAGTCAAAGCGAGATCGGGAGAAGGACAAGAAGAGAGCAGATTCTGTGGCTAACAAACTG GGCAGCTTTGGCAAAACCTTGGGCAGCAAGCTCAAGAAGAACATGGGGGGCCTGATGCACAGCAAGGGT TCAAAGCCTGGAGGGGTGGGGACAGGGTTGGGAGGAAGCAGCGGCACTGAGACACTGGAGAAGAAGAAG AAAAACTCACTGAAGAGCTGGAAGGGTGGCAAGGAGGAGGCAGCTGGGGATGGGCCTGTGTCTGAGAAG CCCCCAGCTGAGTCTGTTGGTAACGGAGGGAGCAAGTATAGCCAGGAGGTGATGCAGAGCCTGAGCATT CTGAGGACTGCCATGCAAGGGGAGGGGAAGTTTATTTTTGTTGGAACCCTGAAGATGGGTCACCGTCAC CAGTATCAGGAGGAAATGATCCAGCGCTACCTTTCTGATGCTGAGGAGAGATTCCTGGCAGAACAGAAG CAGAAGGAGGCAGAGAGGAAGATCATGAATGGAGGAATAGGGGGTGGCCCTCCTCCAGCCAAAAAGCCA GAGCCAGATGCTAGGGAAGAGCAGCCGACCGGTCCCCCAGCAGAGTCCAGGGCAATGGCATTTTCCACT GGCTACCCTGGGGACTTTACTATCCCTCGGCCGTCTGGGGGCGGAGTCCACTGCCAGGAACCCCGGAGG CAGTTGGCAGGGGGTCCATGTGTCGGGGGCCTACCACCATATGCCACCTTCCCCAGACAGTGCCCTCCT GGGCGACCCTACCCCCACCAGGACAGCATCCCTTCTCTGGAGCCAGGCAGCCACTCTAAGGATGGACTT CACAGGGGTGCCTTGTTACCACCCCCCTACCGAGTGGCTGATTCCTATAGCAATGGCTACAGAGAGCCC CCTGAGCCAGATGGATGGGCTGGAGGTCTCCGGGGCCTTCCCCCAACTCAGACCAAATGCAAACAACCG AACTGCAGCTTCTATGGACACCCTGAGACAAACAACTTCTGTTCCTGTTGTTACAGGGAAGAACTGAGG AGGAGGGAGCGGGAACCGGATGGGGAGCTCCTGGTGCACAGGTTCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_020205 |
| Insert Size | 2532 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_020205.3 |
| RefSeq Size | 6415 bp |
| RefSeq ORF | 2532 bp |
| Locus ID | 56957 |
| UniProt ID | Q6GQQ9 |
| MW | 92.5 kDa |
| Gene Summary | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209932 | OTUD7B (Myc-DDK-tagged)-Human OTU domain containing 7B (OTUD7B) |
CNY 6,176.00 |
|
| RC209932L1 | Lenti ORF clone of Human OTU domain containing 7B (OTUD7B), Myc-DDK-tagged |
CNY 8,576.00 |
|
| RC209932L2 | Lenti ORF clone of Human OTU domain containing 7B (OTUD7B), mGFP tagged |
CNY 9,030.00 |
|
| RC209932L3 | Lenti ORF clone of Human OTU domain containing 7B (OTUD7B), Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC209932L4 | Lenti ORF clone of Human OTU domain containing 7B (OTUD7B), mGFP tagged |
CNY 9,030.00 |
|
| RG209932 | OTUD7B (tGFP-tagged) - Human OTU domain containing 7B (OTUD7B) |
CNY 7,776.00 |
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