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KIR2DS3 (NM_012313) Human Untagged Clone
CAT＃: SC303957
KIR2DS3 (untagged)-Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3)
CNY 2,400.00
CNY 6,270.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | NKAT7 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_012313 edited
CCATGTCGCTCATGGTCATCAGCATGGCATGTGTTGGGTTCTTCTGGCTGCAGGGGGCCT GGCCACATGAGGGATTCCGCAGAAAACCTTCCCTCCTGGCCCACCCAGGTCGCCTGGTGA AATCAGAAGAGACAGTCATCCTGCAATGTTGGTCAGATGTCATGTTTGAGCACTTCCTTC TGCACAGAGAGGGGACGTTTAACGACACTTTGCGCCTCATTGGAGAGCACATTGATGGGG TCTCCAAGGCCAACTTCTCCATCGGTCGCATGAGGCAAGACCTGGCAGGGACCTACAGAT GCTACGGTTCTGTTCCTCACTCCCCCTATCAGTTTTCAGCTCCCAGTGACCCTCTGGACA TCGTGATCACAGGTCTATATGAGAAACCTTCTCTCTCAGCCCAGCCGGGCCCCACGGTTC TGGCAGGAGAGAGCGTGACCTTGTCCTGCAGCTCCTGGAGCTCCTATGACATGTACCATC TATCCACGGAGGGGGAGGCCCATGAACGTAGGTTCTCTGCAGGGCCCAAGGTCAACGGAA CATTCCAGGCCGACTTTCCTCTGGGCCCTGCCACCCAAGGAGGAACCTACAGATGCTTCG GCTCTTTCCATGACTCTCCCTACGAGTGGTCAAAGTCAAGTGACCCACTGCTTGTTTCTG TCACAGGAAACCCTTCAAATAGTTGGCCTTCACCCACTGAACCAAGCTCCAAAACCGGTA ACCCCAGACACCTACACGTTCTGATTGGGACCTCAGTGGTCAAACTCCCTTTCACCATCC TCCTCTTCTTTCTCCTTCATCGCTGGTGCTCCGACAAAAAAAATGCATCTGTAATGGACC AAGGGCCTGCGGGGAACAGAACAGTGAACAGGGAGGATTCTGACGAACAGGACCATCAGG AGGTGTCATACGCATAATTGGATCACTGTGTTTTCACACAGAGAAAAATCACTCCCCCTT CTCAGAGGCCCAAGACACCCCCAACAGATAGCAGCATGTACATAGAACTTCCAAATGCTG AGTCCAGATCCAAAGCTGTCTTCTGTCCACGAGCACCACAGTCAGGCCTTGAGGGGATCT TCTAGGGAGTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAACAGATCCCGG GTGGCATCCCTGTGACCCCTCCCCAGTGCCTCTCCTGGCCCTGGAAGTTGCCACTCCAGT GCCCACCAGCCTTGTCCTAATAAAATTAAGTTGCATCATTTTGTCTGACTAGGTGTCCTT CTATAATATTATGGGGTGGAGGG >OriGene 5' read for NM_012313 unedited
CNCACTATAGGGNNCGGCCGCGNAACTCACCATGTTCGCTCATGGTCATCAGCATGGCAT GTGTTGGGTTCTTCTGGCTGCAGGGGGCCTGGCCACATGAGGGATTCCGCAGAAAACCTT CCCTCCTGGCCCACCCAGGTCGCCTGGTGAAATCAGAAGAGACAGTCATCCTGCAATGTT GGTCAGATGTCATGTTTGAGCACTTCCTTCTGCACAGAGAGGGGACGTTTAACGACACTT TGCGCCTCATTGGAGAGCACATTGATGGGGTCTCCAAGGCCAACTTCTCCATCGGTCGCA TGAGGCAAGACCTGGCAGGGACCTACAGATGCTACGGTTCTGTTCCTCACTCCCCCTATC AGTTTTCAGCTCCCAGTGACCCTCTGGACATCGTGATCACAGGTCTATATGAGAAACCTT CTCTCTCAGCCCAGCCGGGCCCCACGGTTCTGGCAGGAGAGAGCGTGACCTTGTCCTGCA GCTCCTGGAGCTCCTATGACATGTACCATCTATCCACGGAGGGGGAGGCCCATGAACGTA GGTTCTCTGCAGGGCCCAAGGTCAACGGAACATTCCAGGCCGACTTTCCTCTGGGCCCTG CCACCCAAGGAGGAACCTACAGATGCTTCGGCTCTTTCCATGACTCTCCCTACGAGTGGT CAAAGTCAAGTGACCCACTGCTTGTTTCTGTCACAGGAAACCCTTCANATAGTTGGCCTT CACCCACTGAACCAAGCTCCAAAACCGGTAACCCCAGACACCTACACGTTCTGATTGNGA CCTCAGTGGTCAAACTCCCTTTCACCATCCTCCTCTTCTTTCTCCTTCATCGCTGGTGCT CCGACAAAAAAATGCATCTGTNATGGACCAAGGG >OriGene 3' read for NM_012313 unedited
AGNAAAGCACTGGGGNAGGGTCACAGGNATGCCACCCGGGATCTGTTCAGGAAACAGCTA TGACCGCGGCCGCAATCTAGAGTCGACTCCCTAGAAGATCCCCTCAAGGCCTGACTGTGG TGCTCGTGGACAGAAGACAGCTTTGGATCTGGACTCAGCATTTGGAAGTTCTATGTACAT GCTGCTATCTGTTGGGGGTGTCTTGGGCCTCTGAGAAGGGGGAGTGATTTTTCTCTGTGT GAAAACACAGTGATCCAATTATGCGTATGACACCTCCTGATGGTCCTGTTCGTCAGAATC CTCCCTGTTCACTGTTCTGTTCCCCGCAGGCCCTTGGTCCATTACAGATGCATTTTTTTT GTCGGAGCACCAGCGATGAAGGAGAAAGAAGAGGAGGATGGTGAAAGGGAGTTTGACCAC TGAGGTCCCAATCAGAACGTGTAGGTGTCTGGGGTTACCGGTTTTGGAGCTTGGTTCAGT GGGTGAAGGCCAACTATTTGAAGGGTTTCCTGTGACAGAAACAAGCAGTGGGTCACTTGA CTTTGACCACTCGTAGGGAGAGTCATGGAAAGAGCCGAAGCATCTGTAGGTTCCTCNCTT GGTGGCAGGGCCCAGAGGAAAGTCGGCCTGGAATGTTCCGTTGACCTTGGGCCCTGCAGA GAACCTACGTTCATGGGCCTCCCCCTCCGTGGATAGATGGTACATGTCATAAGAGCTCCA GGAGCTGCAGGACAAGGTCACGCTCTCTCCTGCCAGAACCGTGGGGCCCGGCTGGGCTGA GAGAAAGGTTTCTCATATAGACCTGTGATCACGATGTCCAGAGGGTCACTGGGAGCTGAA AACTGATAGGGGGAGTGAGG |
| Restriction Sites | Please inquire |
| ACCN | NM_012313 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_012313.1, NP_036445.1 |
| RefSeq Size | 1113 bp |
| RefSeq ORF | 915 bp |
| Locus ID | 3808 |
| UniProt ID | Q14952 |
| Protein Families | Transmembrane |
| Protein Pathways | Antigen processing and presentation, Natural killer cell mediated cytotoxicity |
| Gene Summary | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule
,C J VandenBussche, T J Mulrooney, W R Frazier, S Dakshanamurthy, C K Hurley,
Genes and Immunity (13 Nov 2008), doi: 10.1038/gene.2008.91
[KIR2DS3]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213617 | KIR2DS3 (Myc-DDK-tagged)-Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3) |
CNY 2,400.00 |
|
| RC213617L1 | Lenti ORF clone of Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC213617L2 | Lenti ORF clone of Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3), mGFP tagged |
CNY 5,890.00 |
|
| RC213617L3 | Lenti ORF clone of Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC213617L4 | Lenti ORF clone of Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3), mGFP tagged |
CNY 4,800.00 |
|
| RG213617 | KIR2DS3 (tGFP-tagged) - Human killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 (KIR2DS3) |
CNY 4,000.00 |
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