United States
Germany
Japan
United Kingdom
China
IL12RB1 (NM_005535) Human Untagged Clone
CAT＃: SC303661
IL12RB1 (untagged)-Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1
CNY 4,936.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD212; IL-12R-BETA1; IL12RB; IMD30 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005535 edited
ACCTCGCAGGTGGCAGAGAGGCTCCCCTGGGGCTGTGGGGCTCTACGTGGATCTGATGGA GCCGCTGGTGACCTGGGTGGTCCCCCTCCTCTTCCTCTTCCTGCTGTCCAGGCAGGGCGC TGCCTGCAGAACCAGTGAGTGCTGTTTTCAGGACCCGCCATATCCGGATGCAGACTCAGG CTCGGCCTCGGGCCCTAGGGACCTGAGATGCTATCGGATATCCAGTGATCGTTACGAGTG CTCCTGGCAGTATGAGGGTCCCACAGCTGGGGTCAGCCACTTCCTGCGGTGTTGCCTTAG CTCCGGGCGCTGCTGCTACTTCGCCGCCGGCTCAGCCACCAGGCTGCAGTTCTCCGACCA GGCTGGGGTGTCTGTGCTGTACACTGTCACACTCTGGGTGGAATCCTGGGCCAGGAACCA GACAGAGAAGTCTCCTGAGGTCACCCTGCAGCTCTACAACTCAGTTAAATATGAGCCTCC TCTGGGAGACATCAAGGTGTCCAAGTTGGCCGGGCAGCTGCGTATGGAGTGGGAGACCCC GGATAACCAGGTTGGTGCTGAGGTGCAGTTCCGGCACCGGACACCCAGCAGCCCATGGAA GTTGGGCGACTGCGGACCTCAGGATGATGATACTGAGTCCTGCCTCTGCCCCCTGGAGAT GAATGTGGCCCAGGAATTCCAGCTCCGACGACGGCGGCTGGGGAGCCAAGGAAGTTCCTG GAGCAAGTGGAGCAGCCCTGTGTGCGTTCCCCCTGAAAACCCCCCACAGCCTCAGGTGAG ATTCTCGGTGGAGCAGCTGGGCCAGGATGGGAGGAGGCGGCTGACCCTGAAAGAGCAGCC AACCCAGCTGGAGCTTCCAGAAGGCTGTCAAGGGCTGGCGCCTGGCACGGAGGTCACTTA CCGACTACAGCTCCACATGCTGTCCTGCCCGTGTAAGGCCAAGGCCACCAGGACCCTGCA CCTGGGGAAGATGCCCTATCTCTCGGGTGCTGCCTACAACGTGGCTGTCATCTCCTCGAA CCAATTTGGTCCTGGCCTGAACCAGACGTGGCACATTCCTGCCGACACCCACACAGAACC AGTGGCTCTGAATATCAGCGTCGGAACCAACGGGACCACCATGTATTGGCCAGCCCGGGC TCAGAGCATGACGTATTGCATTGAATGGCAGCCTGTGGGCCAGGACGGGGGCCTTGCCAC CTGCAGCCTGACTGCGCCGCAAGACCCGGATCCGGCTGGAATGGCAACCTACAGCTGGAG TCGAGAGTCTGGGGCAATGGGGCAGGAAAAGTGTTACTACATTACCATCTTTGCCTCTGC GCACCCCGAGAAGCTCACCTTGTGGTCTACGGTCCTGTCCACCTACCACTTTGGGGGCAA TGCCTCAGCAGCTGGGACACCGCACCACGTCTCGGTGAAGAATCATAGCTTGGACTCTGT GTCTGTGGACTGGGCACCATCCCTGCTGAGCACCTGTCCCGGCGTCCTAAAGGAGTATGT TGTCCGCTGCCGAGATGAAGACAGCAAACAGGTGTCAGAGCATCCCGTGCAGCCCACAGA GACCCAAGTTACCCTCAGTGGCCTGCGGGCTGGTGTAGCCTACACGGTGCAGGTGCGAGC AGACACAGCGTGGCTGAGGGGTGTCTGGAGCCAGCCCCAGCGCTTCAGCATCGAAGTGCA GGTTTCTGATTGGCTCATCTTCTTCGCCTCCCTGGGGAGCTTCCTGAGCATCCTTCTCGT GGGCGTCCTTGGCTACCTTGGCCTGAACAGGGCCGCACGGCACCTGTGCCCGCCGCTGCC CACACCCTGTGCCAGCTCCGCCATTGAGTTCCCTGGAGGGAAGGAGACTTGGCAGTGGAT CAACCCAGTGGACTTCCAGGAAGAGGCATCCCTGCAGGAGGCCCTGGTGGTAGAGATGTC CTGGGACAAAGGCGAGAGGACTGAGCCTCTCGAGAAGACAGAGCTACCTGAGGGTGCCCC TGAGCTGGCCCTGGATACAGAGTTGTCCTTGGAGGATGGAGACAGGTGCAAGGCCAAGAT GTGATCGTTGAGGCTC >OriGene 5' read for NM_005535 unedited
GTTCACCATTTGTATACGACTCATATAGGCGGCCGCGNATTCAGATCTGGTACCGAGCTC GGATCCACTAGTAACGGCCGCCATGTGCTGGAATTCGCCCTTACCTCGCAGGTGGCAGAG AGGCTCCCCTGGGGCTGTGGGGCTCTACGTGGATCTGATGGAGCCGCTGGTGACCTGGGT GGTCCCCCTCCTCTTCCTCTTCCTGCTGTCCAGGCAGGGCGCTGCCTGCAGAACCAGTGA GTGCTGTTTTCAGGACCCGCCATATCCGGATGCAGACTCAGGCTCGGCCTCGGGCCCTAG GGACCTGAGATGCTATCGGATATCCAGTGATCGTTACGAGTGCTCCTGGCAGTATGAGGG TCCCACAGCTGGGGTCAGCCACTTCCTGCGGTGTTGCCTTAGCTCCGGGCGCTGCTGCTA CTTCGCCGCCGGCTCAGCCACCAGGCTGCAGTTCTCCGACCAGGCTGGGGTGTCTGTGCT GTACACTGTCACACTCTGGGTGGAATCCTGGGCCAGGAACCAGACAGAGAAGTCTCCTGA GGTCACCCTGCAGCTCTACAACTCAGTTAAATATGAGCCTCCTCTGGGAGACATCAAGGT GTCCAAGTTGGCCGGGCAGCTGCGTATGGAGTGGGAGACCCCGGATAACCAGGTTGGTGC TNGAGTGCAGTTCCGGCACCGGACACCCAGCAGCCCATGGAAGTTGGGCGACTGCGGACC TCANGATGATGATACTGAGTCCTGCCTCTGCCCCCTGGAGATGAATGTGGCCCCAAGAAT TCCAGCTCCGACGACGGCGGCTGGGGAGCCAAGGGAAGTCCTGGAGCAA >OriGene 3' read for NM_005535 unedited
CATTGGNGATGGCAACTTCCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCC ACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGATGCATGCTCGAG CGGCCGCCAGTGTGATGGATATCTGCAGAATTCGCCCTTGAGCCTCAACGATCACATCTT GGCCTTGCACCTGTCTCCATCCTCCAAGGACAACTCTGTATCCAGGGCCAGCTCAGGGGC ACCCTCAGGTAGCTCTGTCTTCTCGAGAGGCTCAGTCCTCTCGCCTTTGTCCCAGGACAT CTCTACCACCAGGGCCTCCTGCAGGGATGCCTCTTCCTGGAAGTCCACTGGGTTGATCCA CTGCCAAGTCTCCTTCCCTCCAGGGAACTCAATGGCGGAGCTGGCACAGGGTGTGGGCAG CGGCGGGCACAGGTGCCGTGCGGCCCTGTTCAGGCCAAGGTAGCCAAGGACGCCCACGAG AAGGATGCTCAGGAAGCTCCCCAGGGAGGCGAAGAAGATGAGCCAATCAGAAACCTGCAC TTCGATGCTGAAGCGCTGGGGCTGGCTCCAGACACCCCTCAGCCACGCTGTGTCTGCTCG CACCTGCACCGTGTAGGCTACACCAGCCCCGCAGCCACTGAGGGTAACTTGNGTCTCTGT GGGCTGCACGGGATGCTCTGACACCTGTTTGCTGTCTTCATCTCGGCAGCGGACAACATA CTCCTTATAGACGCCGGGACAGGTGCTCAACAGGGATGGTGCCCCAGTCCACAGACACAG AGTCCAAGCTATGATTCCTTCACCGAGACGTGGTGCGGTGTCCCAGCTGCTGAGGCATTT GCCCCCAAAGTGTAAGTGGAACCGGACC |
| Restriction Sites | Please inquire |
| ACCN | NM_005535 |
| Insert Size | 2100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | There are 4 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 1 amino acid. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005535.1, NP_005526.1 |
| RefSeq Size | 2100 bp |
| RefSeq ORF | 1989 bp |
| Locus ID | 3594 |
| UniProt ID | P42701 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
| Gene Summary | The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] Transcript Variant: This variant (1) represents the use of an alternate promoter, differs in the 5' UTR and uses a downstream start codon compared to variant 4. The encoded isoform (1, also known as Long) has a shorter N-terminus compared to isoform 4. Sequence Note: The 5' UTR was inferred from partial sequence data. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET
,Lay, CS;Bridges, A;Goulding, J;Briddon, SJ;Soloviev, Z;Craggs, PD;Hill, SJ;,
Cell chemical biology
,PubMed ID 34038748
[IL12RB1]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221974 | IL12RB1 (Myc-DDK-tagged)-Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1 |
CNY 4,928.00 |
|
| RC221974L1 | Lenti ORF clone of Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1, Myc-DDK-tagged |
CNY 7,328.00 |
|
| RC221974L2 | Lenti ORF clone of Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC221974L3 | Lenti ORF clone of Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1, Myc-DDK-tagged |
CNY 7,328.00 |
|
| RC221974L4 | Lenti ORF clone of Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1, mGFP tagged |
CNY 7,328.00 |
|
| RG221974 | IL12RB1 (tGFP-tagged) - Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1 |
CNY 6,528.00 |
其它IL12RB1产品
