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DVL1 (NM_004421) Human Untagged Clone
CAT＃: SC303481
DVL1 (untagged)-Human dishevelled, dsh homolog 1 (Drosophila) (DVL1)
CNY 4,912.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DRS2; DVL; DVL1L1; DVL1P1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_004421 edited
ATGGCGGAGACCAAGATTATCTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAG CTGCCCGTGGCCCCCGAGCGCGTCACGCTGGCCGACTTCAAGAACGTGCTCAGCAACCGG CCCGTGCACGCCTACAAATTCTTCTTTAAGTCCATGGACCAGGACTTCGGGGTGGTGAAG GAGGAGATCTTTGATGACAATGCCAAGCTTCCCTGCTTCAACGGCCGCGTGGTCTCCTGG CTGGTCCTGGCTGAGGGTGCTCACTCGGATGCGGGGTCCCAGGGCACGGACAGCCACACA GACCTGCCCCCGCCTCTTGAGCGGACAGGCGGCATCGGGGACTCCCGGCCCCCCTCCTTC CACCCGAATGTGGCCAGCAGCCGTGACGGGATGGACAACGAGACAGGCACGGAGTCCATG GTCAGTCACCGGCGGGAGCGTGCCCGACGCCGGAACCGCGAGGAGGCCGCCCGGACCAAT GGGCACCCAAGGGGAGACCGACGGCGGGATGTGGGGCTGCCCCCAGACAGCGCGTCCACC GCCCTCAGCAGCGAGCTTGAGTCCAGCAGCTTTGTGGACTCGGACGAGGATGGCAGCACG AGCAGGCTCAGCAGCTCCACGGAGCAGAGCACCTCATCCAGACTCATCCGGAAGCACAAA CGCCGGCGGAGGAAGCAGCGCCTTCGGCAGGCGGACCGGGCCTCCTCCTTCAGCAGCATA ACCGACTCCACCATGTCCCTCAACATCGTCACTGTCACGCTCAACATGGAAAGACATCAC TTTCTGGGCATCAGCATCGTGGGGCAGAGCAACGACCGTGGAGACGGCGGCATCTACATT GGCTCCATCATGAAGGGCGGGGCTGTGGCCGCTGACGGCCGCATCGAGCCCGGCGACATG TTGCTGCAGGTGAATGACGTGAACTTTGAGAACATGAGCAATGACGATGCCGTGCGGGTG CTGCGGGAGATCGTTTCCCAGACGGGGCCCATCAGCCTCACTGTGGCCAAGTGCTGGGAC CCAACGCCCCGAAGCTACTTCACCGTCCCACGGGCTGACCCGGTGCGGCCCATCGACCCC GCCGCCTGGCTGTCCCACACGGCGGCACTGACAGGAGCCCTGCCCCGCTACGAGCTGGAA GAGGCGCCGCTGACGGTGAAGAGTGACATGAGCGCCGTCGTCCGGGTCATGCAGCTGCCA GACTCGGGACTGGAGATCCGCGACCGCATGTGGCTCAAGATCACCATCGCCAATGCCGTC ATCGGGGCGGACGTGGTGGACTGGCTGTACACACACGTGGAGGGCTTCAAGGAGCGGCGG GAGGCCCGGAAGTACGCCAGCAGCTTGCTGAAGCACGGCTTCCTGCGGCACACGGTCAAC AAGATCACCTTCTCCGAGCAGTGCTACTACGTCTTCGGGGATCTCTGCAGCAATCTCGCC ACCCTGAACCTCAACAGTGGCTCCAGTGGGACTTCGGATCAGGACACGCTGGCCCCGCTG CCCCACCCGGCTGCCCCCTGGCCTCTGGGTCAGGGCTACCCCTACCAGTACCCGGGACCC CCACCCTGCTTCCCGCCTGCCTACCAGGACCCGGGCTTTAGCTATGGCAGCGGCAGCACC GGGAGTCAGCAGAGTGAAGGGAGCAAAAGCAGTGGGTCCACCCGGAGCAGCCGCCGGGCC CCGGGCCGTGAGAAGGAGCGTCGGGCGGCGGGAGCTGGGGGCAGTGGCAGTGAATCGGAT CACACGGCACCGAGTGGGGTGGGGAGCAGCTGGCGAGAGCGTCCGGCCGGCCAGCTCAGC CGTGGCAGCAGCCCACGCAGTCAGGCCTCGGCTACCGCCCCGGGGCTCCCCCCGCCCCAC CCCACGACCAAGGCCTATACAGTGGTGGGGGGGCCACCCGGGGGACCCCCTGTCCGGGAG CTGGCTGCCGTCCCCCCGGAATTGACAGGCAGCCGCCAGTCCTTCCAGAAGGCTATGGGG AACCCCTGCGAGTTCTTCGTGGACATCATGTGA >OriGene 5' read for NM_004421 unedited
CGTCTGAATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGCGCCCCGCG TCCGAGCCTCGGGCCGGGCCCTGAGCGCGCGGGCTCCGCGCCGCCGCCGCGCCATGGCGG AGACCAAGATTATCTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAGCTGCCCG TGGCCCCCGAGCGCGTCACGCTGGCCGACTTCAAGAACGTGCTCAGCAACCGGCCCGTGC ACGCCTACAAATTCTTCTTTAAGTCCATGGACCAGGACTTCGGGGTGGTGAAGGAGGAGA TCTTTGATGACAATGCCAAGCTTCCCTGCTTCAACGGCCGCGTGGTCTCCTGGCTGGTCC TGGCTGAGGGTGCTCACTCGGATGCGGGGTCCCAGGGCACGGACAGCCACACAGACCTGC CCCCGCCTCTTGAGCGGACAGGCGGCATCGGGGACTCCCGGCCCCCCTCCTTCCACCCGA ATGTGGCCAGCAGCCGTGACGGGATGGACAACGAGACAGGCACGGAGTCCATGGTCAGTC ACCGGCGGGAGCGTGCCCGACGCCGGAACCGCGAGGAGGCCGCCCGGACCAATGGGCACC CAAGGGGAGACCGACGGCGGGATGTGGGGCTGCCCCCAGACAGCGCGTCCACCGCCCTCA GCAGCGAGCTTGAGTCCAGCAGCTTTGTGGNACTCGACGAGGATGGCAGCACGAGCAGGC TCAGCAGCNTCACGGAGCAGAGCACCTCATCCAGACTCATCCGGAAGCACAAACGCCCGG CGGNAGAAGCAGCGCCTTTTCGCAGGCGACCGGGCCTCCTNCTTCAGCAGCATAACCGAC TTCACCATGT >OriGene 3' read for NM_004421 unedited
NCGCCGCCAGTGGAGGCAATTCGAGCCAGGAAGCATGGGGAGGGTCAAGGGTGCCCCCGG GCTCGTTCAGAAAAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTT TTTAAAATTAAACGCTTTTTAGTGTTTAAAATAAGCAGCATTTTACACAGAAGCAGCTTC TTTGTTTAACCATCTAAACGCTGGGACTTTGATACAGTATCTACAGCACAGACACGTTGG GGGCCAGAGAAGCCAGGAAGGCCGCGATGTGTGCGCGCAGTGTGTGCACTCACCAAGGAC GGGCCACCTGACTGCCCATCTCCCCAAGACCTCCCTCCCTGTGGCAGCTGTGCACATCGG GGCCCCTTGACCCTGCGGGCCATGGTCCCTCCCTGCCCTGGCTGGGACACGGTGGGCAGG ATGTCCAGCCCTCTCTCGTCTTCCGGTCCCGTCCTCCACGTACTTTCAGACTGTTGCCGG ATGGGAGGAGAGAAGGTGCAGGCTGCTCCAAGGGGCAGCAGCAGGTGGGACAGATGACAG GGTCGCCTCCTCCCCCGAGTCACCGGCCAGGCAATAAATAAATAAATTAGATCCCTACTC CAGACAGGGGGCCTGTGCACCGCAGGGGGTTGCCCCGCGTGGACCACCCTGGGGGCCTGG GCACAGCTGTGCAGGAGGTGGGGGTCAGCCGAGAGCCCGAGGGGGTCTTCCTCATCCCAG GAGGGATCCCCACCAGACACAAGGGGTTTTGGGAGGTCCGAGGCTTCTCGCTGAGGGGCA GAGAGGGAGCGCCCCCAACACGGCTGCTCAGACACAGGTGCTGTCAGGAGCTGGAGCAGC CAGGCTGCCAGGGCAGATGGTGGTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004421 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004421.2, NP_004412.2 |
| RefSeq Size | 2941 bp |
| RefSeq ORF | 2013 bp |
| Locus ID | 1855 |
| UniProt ID | O14640 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS |
| Protein Pathways | Basal cell carcinoma, Colorectal cancer, Melanogenesis, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway |
| Gene Summary | DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs
,Desheng Lu, Howard B. Cottam, Maripat Corr, and Dennis A. Carson,
Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18567-71
[DVL1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217691 | DVL1 (Myc-DDK-tagged)-Human dishevelled, dsh homolog 1 (Drosophila) (DVL1) |
CNY 4,912.00 |
|
| RC217691L1 | Lenti ORF clone of Human dishevelled, dsh homolog 1 (Drosophila) (DVL1), Myc-DDK-tagged |
CNY 7,312.00 |
|
| RC217691L2 | Lenti ORF clone of Human dishevelled, dsh homolog 1 (Drosophila) (DVL1), mGFP tagged |
CNY 7,700.00 |
|
| RC217691L3 | Lenti ORF clone of Human dishevelled, dsh homolog 1 (Drosophila) (DVL1), Myc-DDK-tagged |
CNY 7,312.00 |
|
| RC217691L4 | Lenti ORF clone of Human dishevelled, dsh homolog 1 (Drosophila) (DVL1), mGFP tagged |
CNY 7,312.00 |
|
| RG217691 | DVL1 (tGFP-tagged) - Human dishevelled, dsh homolog 1 (Drosophila) (DVL1) |
CNY 6,512.00 |
