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DISC1 (NM_001012957) Human Untagged Clone
CAT＃: SC301729
DISC1 (untagged)-Human disrupted in schizophrenia 1 (DISC1), transcript variant Lv
CNY 9,152.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C1orf136; SCZD9 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_001012957 edited
GGGGCGCATGCCAGGCGGGGGTCCTCAGGGCGCCCCAGCCGCCGCCGGCGGCGGCGGCGT GAGCCACCGCGCAGGCAGCCGGGATTGCTTACCACCTGCAGCGTGCTTTCGGAGGCGGCG GCTGGCACGGAGGCCGGGCTACATGAGAAGCTCGACAGGGCCTGGGATCGGGTTCCTTTC CCCAGCAGTGGGCACACTGTTCCGGTTCCCAGGAGGGGTGTCTGGCGAGGAGTCCCACCA CTCGGAGTCCAGGGCCAGACAGTGTGGCCTTGACTCGAGAGGCCTCTTGGTCCGGAGCCC TGTTTCCAAGAGTGCAGCAGCCCCTACTGTGACCTCTGTGAGAGGAACCTCGGCGCACTT TGGGATTCAGCTCAGAGGTGGCACCAGATTGCCTGACAGGCTTAGCTGGCCGTGTGGCCC TGGGAGTGCTGGGTGGCAGCAAGAGTTTGCAGCCATGGATAGTTCTGAGACCCTGGACGC CAGCTGGGAGGCAGCCTGCAGCGATGGAGCAAGGCGTGTCCGGGCAGCAGGCTCTCTGCC ATCAGCAGAGTTGAGTAGCAACAGCTGCAGCCCTGGCTGTGGCCCTGAGGTCCCCCCAAC CCCTCCTGGCTCTCACAGTGCCTTTACCTCAAGCTTTAGCTTTATTCGGCTCTCGCTTGG CTCTGCCGGGGAACGTGGAGAAGCAGAAGGCTGCCCACCATCCAGAGAGGCTGAGTCCCA TTGCCAGAGCCCCCAGGAGATGGGAGCCAAAGCTGCCAGCTTGGACGGGCCTCACGAGGA CCCGCGATGTCTCTCTCGGCCCTTCAGTCTCTTGGCTACACGGGTCTCTGCAGACTTGGC CCAGGCCGCAAGGAACAGCTCCAGGCCAGAGCGTGACATGCATTCTTTACCAGACATGGA CCCTGGCTCCTCCAGTTCTCTGGATCCCTCACTGGCTGGCTGTGGTGGTGATGGGAGCAG CGGCTCAGGGGATGCCCACTCTTGGGACACCCTGCTCAGGAAATGGGAGCCAGTGCTGCG GGACTGCCTGCTGAGAAACCGGAGGCAGATGGAGGTAATATCCTTAAGATTAAAACTTCA GAAACTTCAGGAAGATGCAGTTGAGAATGATGATTATGATAAAGCTGAGACGTTACAACA AAGATTAGAAGACCTGGAACAAGAGAAAATCAGCCTGCACTTTCAACTTCCTTCAAGGCA GCCAGCTCTTAGCAGTTTCCTGGGTCACCTGGCAGCACAAGTCCAGGCTGCCTTGCGCCG TGGGGCCACTCAGCAGGCCAGCGGAGATGACACCCACACCCCACTGAGAATGGAGCCGAG GCTGTTGGAACCCACTGCTCAGGACAGCTTGCACGTGTCCATCACGAGACGAGACTGGCT TCTTCAGGAAAAGCAGCAGCTACAGAAAGAAATTGAAGCTCTCCAAGCAAGGATGTTTGT GCTGGAAGCCAAAGATCAACAGCTGAGAAGGGAAATAGAGGAGCAAGAGCAGCAACTCCA GTGGCAGGGCTGCGACCTGACCCCACTGGTGGGCCAGCTGTCCCTGGGTCAGCTGCAGGA GGTCAGCAAGGCCTTGCAGGACACCCTGGCCTCAGCCGGTCAGATTCCCTTCCATGCAGA GCCACCGGAAACCATAAGGAGCCTCCAGGAAAGAATAAAATCCCTCAACTTGTCACTTAA AGAAATCACTACTAAGGTGTGTATGAGTGAGAAATTCTGCAGCACCCTGAGGAAGAAAGT TAACGATATTGAAACCCAACTACCAGCCTTGCTTGAAGCCAAAATGCATGCCATATCAGG AAACCATTTCTGGACGGCTAAAGACCTCACCGAGGAGATTAGATCATTAACATCAGAGAG AGAAGGGCTGGAGGGACTCCTCAGCAAGCTGTTGGTGTTGAGTTCCAGGAATGTCAAAAA GCTGGGAAGTGTTAAAGAAGATTACAACAGACTGAGAAGAGAAGTGGAGCACCAGGAGAC TGCCTATGAAACAAGTGTGAAGGAAAATACTATGAAGTACATGGAAACACTTAAGAATAA ACTGTGCAGCTGCAAGTGTCCACTGCTTGGGAAAGTGTGGGAAGCTGACTTGGAAGCTTG TCGATTGCTTATCCAGAGCCTACAGCTCCAGGAAGCCAGGGGAAGCCTGTCTGTAGAAGA TGAGAGGCAGATGGATGACTTAGAGGGAGCTGCTCCTCCTATTCCCCCCAGGCTCCACTC CGAGGATAAAAGGAAGACCCCTTTGAAGGAATCTTACATCCTTTCTGCAGAACTTGGAGA AAAGTGTGAAGACATAGGCAAGAAGCTATTGTACTTGGAAGATCAACTTCACACAGCAAT CCACAGTCATGATGAAGATCTCATTCAGTCTCTCAGGAGGGAGCTCCAGATGGTGAAGGA AACTCTGCAGGCCATGATCCTGCAGCTCCAGCCAGCAAAGGAGGCGGGAGAAAGAGAAGC TGCAGCTTCCTGCATGACAGCTGGTGTCCACGAAGCACAAGCCTGAGGAGTGACGGGATG GGGGAGGGAGGTGGGCCACCATGTTTGGACCCGGGGGGCTGCTCTTCCCTCCCCCGCCAT AGCTAAGATGCCTGAATCAATTACGGAGATACAGAGCCTTGAGGTCTTTCAGTGGAAAGG TGGTTCATGTTCATTCTCATCAGTGTGAAACTGAGGAGTCTGCAATTTGGAATATGGAGA GAGAGACTGATTTGCTGAATTTCCTTCTAAATGTCACTCAAAAATTTCTTTTCCATGTCA TTCTTGAGAATGTCTTCCACAGGATTTGAGAATAGTTTCATCTCAGCCCCCATTAGAGAG AAGTTGGGGTGAATTCTGGAAAAATGTCTCTTTTTCCTGTGCCATTTGCCTTCTGCTGCA ACGAAAATATTTCCTGATTCAAGATTCTATAAAAAGGAAACCAAGCATAAGACTCTGTCA TCATACCTGTTACACGTTCCTACAGGTGCACAATCTAAGAGAGCTAATTAACCTCAGAGT CTGGAGTTAACAGCTTTTCACCTTACT >OriGene 5' read for NM_001012957 unedited
NGGGTTAAATTTGTATACGATCATATAGGCGGCCGCGNAATCGCCCTTAGCGGGGCGCAT GCCAGGCGGGGGTCCTCAGGGCGCCCCAGCCGCCGCCGGCGGCGGCGGCGTGAGCCACCG CGCAGGCAGCCGGGATTGCTTACCACCTGCAGCGTGCTTTCGGAGGCGGCGGCTGGCACG GAGGCCGGGCTACATGAGAAGCTCGACAGGGCCTGGGATCGGGTTCCTTTCCCCAGCAGT GGGCACACTGTTCCGGTTCCCAGGAGGGGTGTCTGGCGAGGAGTCCCACCACTCGGAGTC CAGGGCCAGACAGTGTGGCCTTGACTCGAGAGGCCTCTTGGTCCGGAGCCCTGTTTCCAA GAGTGCAGCAGCCCCTACTGTGACCTCTGTGAGAGGAACCTCGGCGCACTTTGGGATTCA GCTCAGAGGTGGCACCAGATTGCCTGACAGGCTTAGCTGGCCGTGTGGCCCTGGGAGTGC TGGGTGGCAGCAAGAGTTTGCAGCCATGGATAGTTCTGAGACCCTGGACGCCAGCTGGGA GGCAGCCTGCAGCGATGGAGCAAGGCGTGTCCGGGCAGCAGGCTCTCTGCCATCAGCAGA GTTGAGTAGCAACAGCTGCAGCCCTGGCTGTGGCCCTGAGGTCCCCCCAACCCCTCCTGG CTCTCACAGTGCCTTTACCTCAAGCTNTAGCTNTATTCGGCTCTCGCTTGGCTCTGCCGG NGAACGTGGAGAAGCAGAAAGCTGCCCACCATCCAGAGAGGCTGAGTCCCATTGCCAGAG CCCCAGGAGATGGGAGCCAAAGCGCCAGTTTTGGGACGGGCCTCACGAGGACCCCGCGAT GTCTCTCTCGGCCCTTCAGTCTCTGGGCTACACGGGTCTCTGCAGAC >Forward primer walk for NM_001012957 unedited
NTTCTCCTGCATGCCAAATACTATGNAGATACATGGNAAACACTTAAGGATAAACTGTGC AGCTGCAAGTGTCCACTGCTTGGGAAATGTGGGAAGCTGACTTGGAAGCTTGTCGATTGC TTATCCAGAGCCTACAGCTCCAGGAAGCCAGGGGAAGCCTGTCTGTAGAAGATGAGAGGC AGATGGATGACTTAGAGGGAGCTGCTCCTCCTATTCCCCCCAGGCTCCACTCCGAGGATA AAAGGAAGACCCCTTTGAAGGAATCTTACATCCTTTCTGCAGAACTTGGAGAAAAGTGTG AAGACATAGGCAAGAAGCTATTGTACTTGGAAGATCAACTTCACACAGCAATCCACAGTC ATGATGAAGATCTCATTCAGTCTCTCAGGAGGGAGCTCCAGATGGTGAAGGAAACTCTGC AGGCCATGATCCTGCAGCTCCAGCCAGCAAAGGAGGCGGGAGAAAGAGAAGCTGCAGCTT CCTGCATGACAGCTGGTGTCCACGAAGCACAAGCCTGAGGAGTGACGGGATGGGGGANGG GAGGTGGGCCACCATGTTTGGACCCGGGGGGCTGCTCTTCCCTCCCCCGCCATAGCTAAG ATGCCTGAATCAATTACGGAGATACAGAGCCTTGAGGTCTTTCAGTGGAAAGGTGGTTCA TGTTCATTCTCATCAGTGTGAAACTGAGGAGTCTGCAATTTGGAATATGGAGAGAGAGAC TGATTTGCTGAATTTCCTTCTAAATGTCACTCAAAAATTTCTTTTCCATGTCATTCTTGA GAATGTTTCCACAGGATTTGAGAATAGTTTCATCTCAGCCCCCATTAAAGAGAAGTTGGG GTTGAATTCTGGAAAAATGTCTCTTTTTCCTGTGCCATTTGCCTTCTGCTGGCACGAAAA T |
| Restriction Sites | Please inquire |
| ACCN | NM_001012957 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001012957.1, NP_001012975.1 |
| RefSeq Size | 7003 bp |
| RefSeq ORF | 2499 bp |
| Locus ID | 27185 |
| UniProt ID | Q9NRI5 |
| Gene Summary | This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (Lv) has an alternate splice site in the 3' coding region, as compared to variant L. The reading frame is not changed, and the resulting isoform (Lv, also known as the 'Long variant' isoform) lacks an internal segment, as compared to isoform L. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Disrupted-in-Schizophrenia 1 (DISC1) Is Necessary for the Correct Migration of Cortical Interneurons
,null,
The Journal of Neuroscience
,PubMed ID 22238109
[DISC1]
|
|
Disrupted-in-Schizophrenia 1 (DISC1) Is Necessary for the Correct Migration of Cortical Interneurons
,André Steinecke, Christin Gampe, Christina Valkova, Christoph Kaether, and Jürgen Bolz,
J. Neurosci., Jan 2012; 32: 738 - 745.
[DISC1]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC216669 | DISC1 (Myc-DDK-tagged)-Human disrupted in schizophrenia 1 (DISC1), transcript variant Lv |
CNY 9,136.00 |
|
| RC216669L1 | Lenti-ORF clone of DISC1 (Myc-DDK-tagged)-Human disrupted in schizophrenia 1 (DISC1), transcript variant Lv |
CNY 11,536.00 |
|
| RC216669L2 | Lenti-ORF clone of DISC1 (mGFP-tagged)-Human disrupted in schizophrenia 1 (DISC1), transcript variant Lv |
CNY 7,700.00 |
|
| RC216669L3 | Lenti-ORF clone of DISC1 (Myc-DDK-tagged)-Human disrupted in schizophrenia 1 (DISC1), transcript variant Lv |
CNY 7,700.00 |
|
| RC216669L4 | Lenti-ORF clone of DISC1 (mGFP-tagged)-Human disrupted in schizophrenia 1 (DISC1), transcript variant Lv |
CNY 7,700.00 |
|
| RG216669 | DISC1 (tGFP-tagged) - Human disrupted in schizophrenia 1 (DISC1), transcript variant Lv |
CNY 6,370.00 |
