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Syndecan 1 (SDC1) (NM_001006946) Human Untagged Clone
CAT＃: SC301129
SDC1 (untagged)-Human syndecan 1 (SDC1), transcript variant 1
CNY 3,600.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 3,600.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD138; SDC; SYND1; syndecan |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>SC118272 representing NM_002997.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCGGCCGCGAATTCGGCACGAGGCCGAATCCGAGCCGAGCGGAGAGGAATCCGGCAGTAGAGAGCGGAC TCCAGCCGGCGGACCCTGCAGCCCTCGCCTGGGACAGCGGCGCGCTGGGCAGGCGCCCAAGAGAGCATC GAGCAGCGGAACCCGCGAAGCCGGCCCGCAGCCGCGACCCGCGCAGCCTGCCGCTCTCCCGCCGCCGGT CCGGGCAGCATGAGGCGCGCGGCGCTCTGGCTCTGGCTGTGCGCGCTGGCGCTGAGCCTGCAGCCGGCC CTGCCGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGCTCTGGGGATGACTCTGACAAC TTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACCTTGTCACAGCAGACCCCCTCCACTTGGAAG GACACGCAGCTCCTGACGGCTATTCCCACGTCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCC ACCTCCACCCTGCCGGCTGGAGAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCT GGCCTCACCGCCCGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCAT CAGGCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGACATGCAG CCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCACACTCCCCACACAGAG GATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCCTCCAGTCAGCTCCCAGCAGCAGAG GGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCGGGGGAGAATACGGCTGTAGTGGCCGTGGAGCCT GACCGCCGGAACCAGTCCCCAGTGGATCAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAA GAGGTGCTGGGAGGGGTCATTGCCGGAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTC ATGCTGTACCGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGGC GGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGGGAGCCATGCGCCCCCTCCG CCCTGCCACTCACTAGGCCCCCACTTGCCTCTTCCTTGAAGAACTGCAGGCCCTGGCCTCCCCTGCCAC CAGGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCTGCCCACGGAGTCGTGGGGTGTGCTGGGA GCTCCACTCTGCTTCTCTGACTTCTGCCTGGAGACTTAGGGCACCAGGGGTTTCTCGCATAGGACCTTT CCACCACAGCCAGCACCTGGCATCGCACCATTCTGACTCGGTTTCTCCAAACTGAAGCAGCCTCTCCCC AGGTCCAGCTCTGGAGGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGAAGAT CCTGCGGGTGGGGCTTGGGGCTCACACACCTGTAGCACTTACTGGTAGGACCAAGCATCTTGGGGGGGT GGCCGCTGAGTGGCAGGGGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCTAGATATCGACTTG TTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCTTGTTACTTCTGAGGTAAGTTA AGTAAGTTGATTCGGTATCCCCCCATCTTGCTTCCCTAATCTATGGTCGGGAGACAGCATCAGGGTTAA GAAGACTTTTTTTTTTTTTTTAAACTAGGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTG TGTTGTCTCTTGAGTTTGTCGCTCATGTGTGCAACAGGGTATGGACTATCTGTCTGGTGGCCCCGTTTC TGGTGGTCTGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTGC CTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCCCGTGTGAGAA GTGAATGCTGGGACTCAGCCTTCAGACAGAGAGGACTGTAGGGAGGGCGGCAGGGGCCTGGAGATCCTC CTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGGGGCTGCTTCCTCCTGGAAATTGACGAGG GGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCTCCATCCAAGGCCAGGTTCTCCGTTAGCTCCTGTGGCC CCACCCTGGGCCCTGGGCTGGAATCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAA CTCTACTTAATCCAATGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATAAAG TAGTCCTGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC TCTAGATTGCGGCCGC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001006946 |
| Insert Size | 1900 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The open reading frame of this clone has been fully sequenced and found to be a perfect match to the protein associated with this reference, NM_001006946.1. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001006946.1, NP_001006947.1 |
| RefSeq Size | 3309 bp |
| RefSeq ORF | 933 bp |
| Locus ID | 6382 |
| UniProt ID | P18827 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), ECM-receptor interaction |
| Gene Summary | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway
,Haiguo Sun, Yunping Hu, Zhennan Gu, Rick T. Owens, Yong Q. Chen, and Iris J. Edwards,
Carcinogenesis, Oct 2011; 32: 1518 - 1524.
[SDC1]
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Other Versions
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|---|---|---|---|
| RC217847 | SDC1 (Myc-DDK-tagged)-Human syndecan 1 (SDC1), transcript variant 1 |
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| RC217847L1 | Lenti ORF clone of Human syndecan 1 (SDC1), transcript variant 1, Myc-DDK-tagged |
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| RC217847L2 | Lenti ORF clone of Human syndecan 1 (SDC1), transcript variant 1, mGFP tagged |
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| RC217847L3 | Lenti ORF clone of Human syndecan 1 (SDC1), transcript variant 1, Myc-DDK-tagged |
CNY 6,000.00 |
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| RC217847L4 | Lenti ORF clone of Human syndecan 1 (SDC1), transcript variant 1, mGFP tagged |
CNY 6,000.00 |
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| RG217847 | SDC1 (tGFP-tagged) - Human syndecan 1 (SDC1), transcript variant 1 |
CNY 5,200.00 |
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