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p63 (TP63) (NM_003722) Human Untagged Clone
CAT＃: SC128232
TP63 (untagged)-Human tumor protein p63 (TP63), transcript variant 1
CNY 7,480.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC128232 sequence for NM_003722 edited (data generated by NextGen Sequencing)
ATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATCCAG CGTTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACCATG TCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGAT TTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAACCA TCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAGGAC TCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATG GACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCGCAG AACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTCTCT CCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCC TTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGTATTCCACTGAACTGAAGAAA CTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCTCCT CAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTG GTGAAGCGGTGCCCCAACCATGAGCTGAGCCGTGAATTCAACGAGGGACAGATTGCCCCT CCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCCATC ACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACG ACAGTCTTGTACAATTTCATGTGTAACAGCAGTTGTGTTGGAGGGATGAACCGCCGTCCA ATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGCTTT GAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGA AAGCAGCAAGTTTCGGACAGTACAAAGAACGGTGATGGTACGAAGCGCCCGTTTCGTCAG AACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAACTG TTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCC CTGGAACTCATGCAGTACCTTCCTCAGCACACAATTGAAACGTACAGGCAACAGCAACAG CAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAGTCTCCATCTTCATATGGT AACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAG CTTATCAACCCTCAGCAGCGCAACGCCCTCACTCCTACAACCATTCCTGATGGCATGGGA GCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGAGACATGAATGGACTCAGC CCCACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCA CCTCCGTATCCCACAGATTGCAGCATTGTCAGTTTCTTAGCGAGGTTGGGCTGTTCATCA TGTCTGGACTATTTCACGACCCAGGGGCTGACCACCATCTATCAGATTGAGCATTACTCC ATGGATGATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGC ATCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCCCTTCTCATCTCCTGCGGACCCCA AGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGGGGTGAGCGTGTTATTGAT GCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGAC TTCAACTTTGACATGGATGCTCGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGGGAG TGA Clone variation with respect to NM_003722.4 >OriGene 5' read for NM_003722 unedited
NCGTCAAAATTTGTATACGACTCATATAGGCGGCCGCGNATTCAAATCTGGTACCGGTCC GGAATTCCCGGGATATCGTCGACCCACGCGTCCGCCCGGCTTTATATCTATATATACACA GGTATATGTGTATATTTTATATAATTGTTCTCCGTTCGTTGATATCAAAGACAGTTGAAG GAAATGAATTTTGAAACTTCACGGTGTGCCACCCTACAGTACTGCCCTGACCCTTACATC CAGCGTTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGG GATTTTCTGGAACAGCCTATATGTTCAGTTCAGCCCATTGACTTGAACTTTGTGGATGAA CCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG GACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGC ATGGACCAGCAGATTCAGAACGGCTCCTCGTCCACCAGTCCCTATAACACAGACCACGCG CAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTC TCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTG TCCTTCCAGCAGTCGAGCACCGCCAAGTCGGCCACCTGGACGTATTCCACTGAACTGAAG AAACTCTACTGCCAAATTGCANAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCT CCTCAGGGAGCTNGTATCCGCGCCATGCCTGTCTACAAAAAGCTGAGCACGTCACGNAGG TGGTGAACCGTGCCCN >OriGene 3' read for NM_003722 unedited
CCTTGGGGATGGCAACTTCCAGGCCAGNAGAGCACTGGGGNAGGGNNTCACAGGGNATGC CCACCCGGGNATNCTGTTNCAGGNAAACAGCTATGACCGCGGCCGCAATCTAGATACCTA TCACCATACATGATACCCCTTAAGGGAAGGAGTATAGACAAGCCATCCAAAACAAGTAAA TTAAAAAATGGTCAATAAGTGCAACTCAATTTTCTTTCATTTAAATTACATTTTAAACAA TACTCAATGCCCCCCACCCAAAAATCTATACTGTATATTTATACATTTATATATATAGTC TTAGACTATAAGGGTGAACATGCTTTATAAAAGTCAATGAGAAATCTCTGCAGCTTAAGG AGACACCCAACTCTTTTTTGCTCACTTCTACCTAGCCATGGCAGCTACAGTTCTGCAAGC TATAGTTTTGAAGGCTTAAAGCCAGAATCAGAATTAGATGCCAGGTCAGATGTTAGGTAA GAGGTAGCCTCTTACTTCTCCTTCCCCTAAGAAATCAGACAAGAGGAAGGGGAGGAGCTA GGGAGAAGGCTTTGAAGATTAAGCAGGAGTGCTTTTAGGGGGCTGGCAGTTAGGAGAGGG ATAGGAAGAGCTCACATGGTGAGGCTCACTCCCCCTCCTCTTTGATGCGCTGTTGCTTAT TGCGGCGAGCATCCATGTCAAAGTTGAAGTCATTCCACTCATCTCGGGGTGGGAAAGAGA TGGTCTGGGCGGAGGTGAATCGCACAGCATCAATAACACGCTCACCCCGGGTCTCACTGG AGCCCACACTGACTGTAGAGGCACTGCTTGGNGTCCGCAGNAGATGAAGAAGGGAGGAGA ATTCNTGGAGCTTGCGGTGGGTCCAGATGCCCTTTCAGATCGCATGTTCAAATTGCT |
| Restriction Sites | Please inquire |
| ACCN | NM_003722 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003722.3, NP_003713.3 |
| RefSeq Size | 4932 bp |
| RefSeq ORF | 2043 bp |
| Locus ID | 8626 |
| UniProt ID | Q9H3D4 |
| Domains | SAM, P53 |
| Protein Families | Druggable Genome, Transcription Factors |
| Gene Summary | This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016] Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1, also known as TAp63alpha, TA-alpha, KET, and p51B). This isoform is expressed in female germ cells and acts to protect the germline by eliminating oocytes that have suffered DNA damage. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins
,Coppari, E;Yamada, T;Bizzarri, AR;Beattie, CW;Cannistraro, S;,
Int J Nanomedicine 1799-813 9 . April 2014
,PubMed ID 24748790
[TP63]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208013 | TP63 (Myc-DDK-tagged)-Human tumor protein p63 (TP63), transcript variant 1 |
CNY 4,984.00 |
|
| RC208013L1 | Lenti ORF clone of Human tumor protein p63 (TP63), transcript variant 1, Myc-DDK-tagged |
CNY 7,384.00 |
|
| RC208013L2 | Lenti ORF clone of Human tumor protein p63 (TP63), transcript variant 1, mGFP tagged |
CNY 7,700.00 |
|
| RC208013L3 | Lenti ORF clone of Human tumor protein p63 (TP63), transcript variant 1, Myc-DDK-tagged |
CNY 7,384.00 |
|
| RC208013L4 | Lenti ORF clone of Human tumor protein p63 (TP63), transcript variant 1, mGFP tagged |
CNY 7,384.00 |
|
| RG208013 | TP63 (tGFP-tagged) - Human tumor protein p63 (TP63), transcript variant 1 |
CNY 6,584.00 |
|
| SC322630 | TP63 (untagged)-Human tumor protein p63 (TP63), transcript variant 1 |
CNY 7,480.00 |
