United States
Germany
Japan
United Kingdom
China
MTMR6 (NM_004685) Human Untagged Clone
CAT＃: SC128024
MTMR6 (untagged)-Human myotubularin related protein 6 (MTMR6)
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_004685, the custom clone sequence may differ by one or more nucleotides
ATGGAGCATATCCGGACGACCAAGGTCGAACAAGTAAAATTACTTGACCGATTCAGTACCAGCAACAAGT CATTAACAGGAACACTGTATCTTACGGCTACACATCTATTATTTATCGACTCTCATCAAAAAGAAACCTG GATATTACACCACCATATTGCCTCAGTAGAGAAACTTGCTTTGACTACTTCTGGATGCCCCCTTGTGATA CAGTGCAAGAACTTCAGAACTGTGCATTTCATTGTTCCCAGAGAAAGAGATTGCCATGATATTTACAACT CTTTGCTACAACTGTCAAAACAAGCAAAATATGAAGATCTCTATGCATTTTCTTATAATCCCAAACAAAA TGATTCAGAACGACTACAAGGCTGGCAGCTCATTGATCTCGCTGAGGAATATAAGAGGATGGGAGTGCCA AACTCACACTGGCAGTTGTCTGATGCCAACCGGGACTACAAGATTTGTGAAACTTACCCCAGAGAACTTT ATGTTCCCCGGATAGCAAGCAAACCAATAATTGTTGGTAGTTCCAAGTTCCGGAGCAAGGGAAGATTCCC AGTTCTTTCCTACTATCATCAAGATAAGGAGGCTGCCATTTGTCGATGTAGTCAGCCACTCTCTGGATTC AGTGCCAGGTGCCTGGAGGATGAACATTTGCTTCAAGCCATTAGTAAAGCCAATCCAGTCAATCGCTATA TGTACGTCATGGATACCAGGCCAAAACTGAATGCAATGGCCAACAGAGCAGCTGGAAAAGGTTATGAAAA TGAAGACAACTATTCCAATATTAGATTTCAGTTTGTTGGAATTGAAAATATTCATGTCATGAGGTCCAGC CTTCAGAAATTATTGGAAGTCAATGGCACTAAAGGGCTTTCTGTCAATGATTTCTACTCCGGTTTGGAGA GCTCGGGATGGCTTCGCCATATCAAAGCTGTTATGGATGCTGCAATCTTCTTGGCCAAAGCAATAACAGT TGAAAATGCAAGTGTGTTGGTGCATTGTTCCGATGGTTGGGATAGGACTTCCCAGGTTTGTTCCCTGGGT TCTCTTTTATTGGATTCCTACTACAGGACAATCAAAGGATTCATGGTTTTAATAGAAAAGGATTGGATCT CTTTTGGACATAAATTTTCAGAGAGGTGTGGCCAGTTGGATGGTGACCCAAAGGAAGTCTCACCAGTGTT TACTCAGTTCTTGGAATGTGTGTGGCATTTGACCGAACAGTTTCCACAAGCCTTTGAATTCAGTGAAGCA TTTCTTCTTCAGATCCATGAGCATATTCATTCATGCCAGTTTGGAAACTTCCTTGGAAATTGTCAGAAGG AAAGAGAAGAGCTCAAGTTGAAGGAGAAGACTTATTCCCTGTGGCCATTTCTTTTGGAAGACCAAAAGAA GTACTTAAATCCTCTCTACAGTTCCGAATCTCACAGATTTACAGTTTTGGAGCCAAATACAGTATCTTTC AATTTTAAGTTTTGGAGGAACATGTACCATCAATTTGATCGAACACTGCATCCTAGGCAGTCTGTATTTA ATATAATTATGAATATGAATGAGCAAAATAAACAATTAGAGAAAGATATTAAAGACCTAGAATCTAAAAT TAAACAACGCAAAAATAAGCAAACAGATGGCATCCTCACCAAGGAATTGTTACATTCAGTTCATCCTGAA TCACCTAACCTCAAAACTTCCCTGTGTTTTAAAGAGCAGACTCTGCTACCCGTAAATGATGCTCTTCGAA CTATAGAGGGCAGCAGCCCGGCAGATAATCGTTATAGTGAATATGCAGAAGAGTTTTCTAAATCAGAACC TGCTGTGGTCAGCTTAGAGTATGGTGTGGCAAGAATGACTTGTTAG >OriGene 5' read for NM_004685 unedited
TTTCTTATAGGGNNCGGCCGAGAACTTCGGCACGAGGGCTGCCGGCTGACGTCTCCTTGC GATGGAGCATATCCGGACGACCAAGGTCGAACAAGTAAAATTACTTGACCGATTCAGTAC CAGCAACAAGTCATTAACAGGAACACTGTATCTTACGGCTACACATCTATTATTTATCGA CTCTCATCAAAAAGAAACCTGGATATTTCACCACCATATTGCCTCAGTAGAGAAACTTGC TTTGACTACTTCTGGATGCCCCCTTGTGATACAGTGCAAGAACTTCAGAACTGTGCATTT CATTGTTCCCAGAGAAAGAGATTGCCATGATATTTACAACTCTTTGCTACAACTGTCAAA ACAAGCAAAATATGAAGATCTCTATGCATTTTCTTATAATCCCAAACAAAATGATTCAGA ACGACTACAAGGCTGGCAGCTCATTGATCTCGCTGAGGAATATAAGAGGATGGGAGTGCC AAACTCACACTGGCAGTTGTCTGATGCCAACCGGGACTACAAGATTTGTGAAACTTACCC CAGAGAACTTTATGTTCCCCGGATAGCAAGCAAACCAATAATTGTTGGTAGTTCCAAGTT CCGGAGCAAGGGAAGATTCCCAGTTCTTTCCTACTATCATCAAGATAAGGAGGCTGCCAT TTGTCGATGTAGTCAGCCACTCTCTGGATNCAGTGCCANGTGCCTGGAGGATGAACATTT GCTTCAGCCATTTAGTAAGCCAATCCAGTCAATCGCTATATGTACGTCATGGATACCANG CCANNAACTGATGCAATGGCCANCAGAGCAGCTGGAANAGGNNTATGAAATGAAGACCAC TATTCCCATATAGATTTCAGTTGGGTGGAATGAAAATATNCTGCCATGAGGGTCAGCCTC AAAANTATTGGAGTCATGGCCTAAGGGCTTNTGTCATGATNCTACTCGGNTGGAAGCTCG GGATGCTCGCATACAGCTGTATGGAGCTGCAGCTCTTGCCAGCATACAGTGAAATGCAGG TGGTGTGCATGTTCGAGGT >OriGene 3' read for NM_004685 unedited
AATATTTGNCCGCGGCCGCATTCTANGATCGGTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGGGGCCCCTTTGGTTTATCCCAAAAAAA AACCTTCAAAGGAAAAGGGGAACCTTTAATTACCTTTAAATCATATTTGAAAAAATTTAC ATGGTTTACCCTTCCAAACCCCCTGAACATAAATTCAACTTTTTAAAAAATATACCCAGG TTGGTTTTGGCAACATAAACCCTGGGGGGCACTTAAAAAGGAACTGGTTTTTCAACCCCC CTGGGGGCATATAAACCCCCAAATGTTTGTTTGAAGTTGAAAATTAAAAAAATAAACCCG AGTTGAATCCCAAAAGTCCGCCCCAAAAAATTTTAAAACCCCAATCAGGGGCGGGAACCC CAAGGGCCAAAAACTTCCCTTTGGAGTCACAAAAATTAAATTTCCATTCCCAGGGCTTAA ATATGGAAGCAGGATTGGGTAAACACAAACTATTTTTTATAGGGCATTTTTGGGGGTGGT TAAAAAGGAAAATTTTTTAAATTACCTAAGGGTTTACAAAAAAGCCTTGGAAAAATAAAC CGGGTAAAAAAAGCTCTCATACAAAAAAGGTTTTTTTGGGCTGAAAAAAAAGTTTATTTT CAAAACTAATATAATAAAGGGGTAACAAAAAGTTCCCTGGGGAACACTTTGCAAATTGCC TAATACTCGAATTGGACTTCATGCCACCATGGTATTTAAATTTTCAATTTTAAAGCCCGT TGGGTGAAATTGCTAATTCCAGGGATAGTTGGGGGGTTTAAAAGGGTTGGGTCCTGGGTT TTGGGGAATTAAAGATATGGCCTGTACCCAGAATAAACAGTAATATACATGGCAAATGAA TCTTCCCAAAATTAATGTGCCTTTTGTTAACAGAACCTTGACTAAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004685 |
| Insert Size | 4100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004685.2, NP_004676.2 |
| RefSeq Size | 4201 bp |
| RefSeq ORF | 1866 bp |
| Locus ID | 9107 |
| UniProt ID | Q9Y217 |
| Domains | PTPc_motif |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | Fructose and mannose metabolism, Metabolic pathways, Riboflavin metabolism, Thiamine metabolism |
| Gene Summary | Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208069 | MTMR6 (Myc-DDK-tagged)-Human myotubularin related protein 6 (MTMR6) |
CNY 4,624.00 |
|
| RC208069L1 | Lenti ORF clone of Human myotubularin related protein 6 (MTMR6), Myc-DDK-tagged |
CNY 7,024.00 |
|
| RC208069L2 | Lenti ORF clone of Human myotubularin related protein 6 (MTMR6), mGFP tagged |
CNY 6,460.00 |
|
| RC208069L3 | Lenti ORF clone of Human myotubularin related protein 6 (MTMR6), Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC208069L4 | Lenti ORF clone of Human myotubularin related protein 6 (MTMR6), mGFP tagged |
CNY 6,460.00 |
|
| RG208069 | MTMR6 (tGFP-tagged) - Human myotubularin related protein 6 (MTMR6) |
CNY 5,040.00 |
