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ABAT (NM_020686) Human Untagged Clone
CAT＃: SC127432
ABAT (untagged)-Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 1
CNY 3,728.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GABA-AT; GABAT; NPD009 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_020686, the custom clone sequence may differ by one or more nucleotides
ATGGCCTCCATGTTGCTCGCCCAGCGCCTGGCCTGCAGCTTCCAGCACAGCTACCGCCTGCTGGTGCCTG GATCCAGACACATTAGTCAAGCTGCAGCCAAAGTCGACGTTGAATTTGATTATGATGGGCCTCTGATGAA GACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAACAGCTGAATATAATTCAGAATGCAGAGGCT GTGCATTTTTTCTGCAATTACGAAGAGAGCCGAGGCAATTACCTGGTTGATGTGGACGGCAACCGAATGC TGGATCTTTATTCCCAGATCTCCTCTGTCCCCATAGGTTACAGCCACCCCGCCCTGCTGAAACTCATCCA ACAGCCTCAAAATGCGAGCATGTTTGTCAACAGACCCGCCCTCGGAATCCTGCCTCCGGAGAACTTTGTG GAGAAGCTCCGGCAGTCCTTGCTCTCGGTGGCTCCCAAAGGGATGTCCCAGCTCATCACCATGGCCTGCG GCTCCTGCTCCAATGAAAACGCCTTAAAGACCATCTTCATGTGGTACCGGAGCAAGGAAAGAGGGCAGAG GGGCTTCTCCCAGGAGGAGCTGGAGACGTGCATGATTAACCAGGCCCCTGGCTGCCCCGACTACAGCATC CTCTCCTTCATGGGCGCGTTCCATGGGAGGACCATGGGTTGCTTAGCGACCACGCACTCTAAAGCCATTC ACAAGATCGACATCCCTTCCTTTGACTGGCCCATCGCACCGTTCCCACGGCTGAAATACCCTCTGGAAGA GTTTGTGAAAGAGAACCAACAGGAGGAGGCCCGCTGTCTGGAAGAGGTGGAGGATCTGATTGTGAAATAT CGGAAAAAGAAGAAGACGGTGGCCGGGATCATCGTGGAGCCCATCCAGTCCGAGGGTGGAGACAACCACG CATCCGATGACTTCTTTCGGAAGCTGAGAGACATCGCCAGGAAGCATGGCTGCGCCTTCTTGGTGGACGA GGTCCAGACCGGAGGAGGCTGCACGGGCAAGTTCTGGGCCCATGAGCACTGGGGCCTGGATGACCCAGCA GACGTGATGACCTTCAGCAAGAAGATGATGACTGGGGGCTTCTTCCACAAGGAGGAGTTCAGGCCTAATG CTCCCTACCGGATCTTCAACACCTGGCTGGGGGACCCGTCCAAGAACCTGTTGCTGGCTGAGGTCATCAA CATCATCAAGCGGGAGGACCTGCTAAATAATGCAGCCCATGCCGGGAAGGCCCTGCTCACAGGACTGCTG GACCTCCAGGCCCGGTACCCCCAGTTCATCAGCAGGGTGAGAGGACGAGGCACCTTTTGCTCCTTCGATA CTCCCGATGATTCCATACGGAATAAGCTCATTTTAATTGCCAGAAACAAAGGTGTGGTGTTGGGTGGCTG TGGTGACAAATCCATTCGTTTCCGTCCCACGCTGGTCTTCAGGGATCACCACGCTCACCTGTTCCTCAAT ATTTTCAGTGACATCTTAGCAGACTTCAAGTAA >OriGene 5' read for NM_020686 unedited
CACTATAGGGCGGCCGCGAATTCGGCACGAGGCTCTCCCTTGCGCACTTGCCGGGTACCA GCTGAGTGCATCCTTTTCCCAAACCTGCTCTGCTTCCAAGGGGCCCTTTTCTGTCTCCTC CACCTGTCCCCATGTTTTGGGGACTGCCTGGAAATCCGGGACACCCTCCTGAGGAGGGAG CTGGTGCCCAACGGCACCTCTTAGGATGAACCCAGCCAGCTGCGTTCCTGGCCTCTGCAG AATGGCATACAGAAGGCATTTTAAGCAAGCGAGCTGAGCTCGCCGCAGGACTCCGACTAC CAGGCACCGGTGGCAGCACGCAAAGGGTGTCCCTGTCCCTCAAGGGGTCATGGCCTCCAT GTTGCTCGCCCAGCGCCTGGCCTGCAGCTTCCAGCACAGCTACCGCCTGCTGGTGCCTGG ATCCAGACACATTAGTCAAGCTGCAGCCAAAGTTCGACGTTGAATTTGATTATGATGGGC CTCTGATGAAGACGGAAGTCCCAGGGCCTAGATCTCAGGAGTTAATGAAACAGCTGAATA TAATTCAGAATGCAGAGGCTGTGCATTTTTTCTGCAATTACGAAGAGAGCCGAGGCAATT ACCTGGTTTGATGGTGGACGGCAACCGAATGGCTGGATCTTTATTCCCAGATCTCCTCTG NTCCCATAGGNTACAGCCACCCCGCCCTGCTGAAACTCATNCAACAGCCTCAAATGCGAG CCTTGTTTGTCAACAGACCCGCCTCGGAATCCTGCTNCGGANAACNTTGGGGANAACTTN CNGCAGTCTTGNTTTTCGGGGCTCAAAANNGGGATGTCCCANTTATAACCATGGGCTGGG GGTTCTGCTCA >OriGene 3' read for NM_020686 unedited
CAGCTTGCCCGCGGCCGCAATCTAGGATCGGTTTTTTTTTTTTTTTTTTTAAATTATAAA TTTTATTTAAGAATACTGACTAACACAGGAAAACAGATTTAATTCATGGAATTGTGCATA TGGTCATCCGTTACATTGTGACATGTTAATTTTTTTTTTATCATTTATTGGCACTGTCAA CAGATTACTTGTGAACAAGATCACTTTGTACGCTTAAGTCTGCGATGCTACTTAGCTATG GTTTTCTACCATGAGCTTATATATAGATAGGTGTAGGTATGTAGATACATTAATGCTATA CACAATTTTGCATGGTTACTGAGCGTCAGTAAAAATTATGAAAAAACACCCATTTATAAT AAAAGTGAGGATGTACTAAGACTTGCTATTACTGGACCTTGTTTTCTGTAAAAGTGATGA CACTTGCTGGACGGTTACTAAACTCTATGGCACTAATGTATGATGGATTCATTTCCAGAC TGTCGGCCACGGAAGCACTTCTTCATGGCCTCTGCCCTGGACAGCAGCCTGTCCTCCGGG CTCCCCATGTTTTTACCAGCTTCTGCTGAGTTTCTACAATCTTGAGCTCTGCTGAGAATT CTTTTCCTTGAAATTCTTCTACCTAAAGCCCCAGCCCCCAAAAGAGCATGTCTCAGGAAC TCATTATGCCCTGAGTCAACANGAACTTGTTGATAAATGGCTTAAAAGTTTTTACAAGAA AGTACTTCCCTTGGTAAGGAGTAAATAATAGCTCTGGAATTTTCCAGATAAAACTATTTN ATTTNCTCTGTCAGTGGCCCCATGGGGGAGAGAACGAAATTATTGGAGCCTCTCTCCCTA CCAAAGAGAGCCACTTNTTCTGGNTGTGCCCCTGNCCTTAAAACCCTTTTGAACTCCGCA GACCCATACTGAATTATTTGCACCCAATGCCTAAGTTTTTCAGGAGAAGACCTTACTTAA GCCCAATAAN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_020686 |
| Insert Size | 5270 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_020686.3, NP_065737.2 |
| RefSeq Size | 4830 bp |
| RefSeq ORF | 1503 bp |
| Locus ID | 18 |
| UniProt ID | P80404 |
| Protein Families | Druggable Genome |
| Protein Pathways | Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Butanoate metabolism, Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation |
| Gene Summary | 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) has a more distal alternate 5' UTR. Variants 1-3 encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
High-yield synthesis and purification of recombinant human GABA transaminase for high-throughput screening assays
,null,
Journal of Enzyme Inhibition and Medicinal Chemistry
,PubMed ID 34514924
[ABAT]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC218980 | ABAT (Myc-DDK-tagged)-Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 1 |
CNY 3,656.00 |
|
| RC218980L3 | Lenti ORF clone of Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged |
CNY 6,460.00 |
|
| RC218980L4 | Lenti ORF clone of Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged |
CNY 6,460.00 |
|
| RG218980 | ABAT (tGFP-tagged) - Human 4-aminobutyrate aminotransferase (ABAT), nuclear gene encoding mitochondrial protein, transcript variant 1 |
CNY 5,256.00 |
