INSIG1 (NM_198336) Human Untagged Clone
CAT#: SC126582
INSIG1 (untagged)-Human insulin induced gene 1 (INSIG1), transcript variant 2
CNY 3,990.00
Product images
Specifications
Product Data | |
Type | Human Untagged Clone |
Tag | Tag Free |
Synonyms | CL6 |
Vector | pCMV6-XL5 |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | None |
Restriction Sites | NotI-NotI |
ACCN | NM_198336 |
Insert Size | 3240 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_198336.1, NP_938150.1 |
RefSeq Size | 3049 bp |
RefSeq ORF | 993 bp |
Locus ID | 3638 |
UniProt ID | O15503 |
Protein Families | Druggable Genome, Transmembrane |
Gene Summary | This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016] Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC219403 | INSIG1 (Myc-DDK-tagged)-Human insulin induced gene 1 (INSIG1), transcript variant 2 |
CNY 3,990.00 |
|
RC219403L1 | Lenti ORF clone of Human insulin induced gene 1 (INSIG1), transcript variant 2, Myc-DDK-tagged |
CNY 5,040.00 |
|
RC219403L2 | Lenti ORF clone of Human insulin induced gene 1 (INSIG1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
RC219403L3 | Lenti ORF clone of Human insulin induced gene 1 (INSIG1), transcript variant 2, Myc-DDK-tagged |
CNY 5,890.00 |
|
RC219403L4 | Lenti ORF clone of Human insulin induced gene 1 (INSIG1), transcript variant 2, mGFP tagged |
CNY 5,890.00 |
|
RG219403 | INSIG1 (tGFP-tagged) - Human insulin induced gene 1 (INSIG1), transcript variant 2 |
CNY 4,240.00 |