C19orf46 (SYNE4) (BC052573) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	FLJ36445
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC052573 edited TTCGGCACGAGGCTCCAGCGGAGGAGCTCTGGGACACCCTTGTCTAGGGAAGAGGTCTTA CTGGCTGCCCTCACCTGACTTTGTGTCCCCAGGCCCCCAGCCATGGCCCTGTCCCTGCCT CTGGGCCCTAGACTTGGCTCAGAGCCCCTCAACCACCCACCGGGAGCACCTAGAGAGGCG GACATTGTTGGATGCACCGTCTGCCCCGCGTCCGGAGAGGAGAGCACGAGCCCAGAGCAG GCCCAGACCCTGGGACAGGACTCCTTGGGCCCTCCTGAGCACTTCCAGGGTGGGCCAAGG GGCAATGAGCCTGCCGCTCACCCCCCGAGATGGTCAACACCCTCTTCCTACGAGGACCCA GCTGGGGGCAAACACTGTGAGGTGTTCGAGGAGGCCAACACGCTGGACCAGGACTTGGAG GTCGAGGGAGACTCGGACTGGCCAGGACCTGGTGGGGTCTGGGGGCCCTGGGCACCCAGT AGCCTCCCCACTTCCACAGAGTTGGAGTGGGATCCGGCGGGGGACATTGGGGGCCTTGGG CCCTTGGGACAAAAGACAGCCCGGACACTAGGAGTGCCCTGTGAGCTGTGTGGCCACAGG GGGCCCCAGGGCAGGGGACAAGGCCTTGAGGAAGCAGACACCTCTCACTCCCGACAGGAC ATGCTGGAGTCTGGCCTCGGCCACCAGAAACGCTTAGCACGTCACCAAAGACACTCCCTG CTCCGGAAGCCTCAGGACAAGAAGAGGCAAGCATCTCCTCATCTCCAGGATGTGAGGCTG GAGGGGAATCCAGGGGCCCCCGATCCTGCATCCAGGCAGCCTCTGACCTTCCTCCTTATC CTCTTCCTCCTCTTCCTCCTCCTGGTGGGTGCCATGTTTCTCCTGCCCGCGTCAGGAGGC CCCTGCTGCTCTCATGCCCGAATACCCAGGACACCCTACCTGGTGCTCAGCTATGTCAAT GGTCTTCCCCCAGTCTGATGTGTGTAATAAATGGTCACTGTCAAAAAAAAAAAAAAAAAA AAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC052573 unedited NGGTTCAGATTTTGTATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGGCTCCAG CGGAGGAGCTCTGGGACACCCTTGGGTAGGGAAGAGGTCTTACTGGCTGCCCTCACCTGA CTTTGTGTCCCCAGGCCCCCAGCCATGGCCCTGTCCCTGCCTCTGGGCCCTAGACTTGGC TCAGAGCCCCTCAACCACCCACCGGGAGCACCTAGAGAGGCGGACATTGTTGGATGCACC GTCTGCCCCGCGTCCGGAGAGGAGAGCACGAGCCCAGAGCAGGCCCAGACCCTGGGACAG GACTCCTTGGGCCCTCCTGAGCACTTCCAGGGTGGGCCAAGGGGCAATGAGCCTGCCGCT CACCCCCCGAGATGGTCAACACCCTCTTCCTACGAGGACCCAGCTGGGGGCAAACACTGT GAGGTGTTCGAGGAGGCCAACACGCTGGACCAGGACTTGGAGGTCGAGGGAGACTCGGAC TGGCCAGGACCTGGTGGGGTCTGGGGGCCCTGGGCACCCAGTAGCCTCCCCACTTCCACA GAGTTGGAGTGGGATCCGGCGGGGGACATTGGGGGCCTTGGGCCCTTGGGACAAAAGACA GCCCGGACACTANGAGTGCCCTGTGAGCTGTGTGGCCACAGGGGGCCCCANGGCAGGGGA CAAGGCCTTGAGGAAGCAGACACCTCTCACTCCCGACAGGACATGCTGGAGTCTGGCCTC NGCCACCANAAACGCTTAGCACGTCACCAAAGACACTCCCTGCTCCCGGAGCCTCAGGAC AAGAGAGGCAAGCATCTCCTCATCTCCAGGATGTGAGGCTGGAGGGGAATCCAGGGGCCC CCGATCCTGCATNCAGGCAGCCTCTGACCTTCCTCCTATNCTCTTNCTCCTCTTCCTCCC CTGGGGGGGGCCATGTTTCTCCTGCCCCGTCAGGAGGC
Restriction Sites	Please inquire
ACCN	BC052573
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC052573.1, AAH52573.1
RefSeq Size	1026 bp
RefSeq ORF	873 bp
Locus ID	163183
Protein Families	Transmembrane
Gene Summary	This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

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