Dematin (DMTN) (BC052805) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	dematin; DMT; erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); FLJ78462; FLJ98848
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC052805 edited GTGACCTTGTGGGGAAAGGAGCCAAGAACGGGGCGTCGGGGGGCCTGGGACCCCCCTGCC TGAGAGATACAGGAATCCTGGCCCCGTGTTGTGGACACAAGCGCCCATCCTCAAGGTCCT GAGAACTCCTGAACTTCCAAAGCCTGGAGAGTCACCGCCGAGGGATGAGGACGCGCCAGC CCGGGGGAACGCGCCAGCTGCTTTCGCGGCCCCAAGCGCGCAGTGCCCAGCAGCCGCGCC GAGCCTGACACGCTGTCCTCTCCCCTCGCGCACAGGGCTCTGCGAGTGACCCGGCGGGCG AGCTCCGTGCTGCATGGAACGGCTGCAGAAGCAACCACTTACCTCCCCCGGGAGCGTGAG CCCCTCCCGAGATTCCAGTGTGCCTGGCTCTCCCTCCAGCATCGTGGCCAAGATGGACAA TCAGGTGCTGGGCTACAAGGACCTGGCTGCCATCCCCAAGGACAAGGCCATCCTGGACAT CGAGCGGCCCGACCTCATGATCTACGAGCCTCACTTTACTTATTCCCTCCTGGAACACGT GGAGCTGCCTCGCAGCCGCGAGCGCTCGCTGTCACCCAAATCCACATCCCCCCCACCATC CCCAGAGGTGTGGGCGGACAGCCGGTCGCCTGGAATCATCTCTCAGGCCTCGGCCCCCAG AACCACTGGAACCCCCCGGACCAGCCTGCCCCATTTCCACCACCCTGAGACCTCCCGCCC AGATTCCAACATCTACAAGAAGCCTCCCATCTATAAGCAGAGAGAGTCCGTGGGAGGCAG CCCTCAGACCAAGCACCTCATCGAGGATCTCATCATCGAGTCATCCAAGTTTCCTGCAGC CCAGCCCCCAGACCCCAACCAGCCAGCCAAAATCGAAACCGACTACTGGCCATGCCCCCC GTCTCTGGCTGTTGTGGAGACAGAATGGAGGAAGCGGAAGGCGTCTCGGAGGGGAGCAGA GGAAGAGGAGGAGGAGGAAGATGACGACTCTGGAGAGGAGATGAAGGCTCTCAGGGAGCG TCAGAGAGAGGAACTCAGTAAGGTTACTTCCAACTTGGGAAAGATGATCTTGAAAGAAGA GATGGAAAAGTCATTGCCGATCCGAAGGAAAACCCGCTCTCTGCCTGACCGGACACCCTT CCATACCTCCTTGCACCAGGGAACGTCTAAATCTTCCTCTCTCCCCGCCTATGGCAGGAC CACCCTGAGCCGGCTACAGTCCACAGAGTTCAGCCCATCAGGGAGTGAGACTGGAAGCCC AGGCCTGCAGATCTATCCCTATGAAATGCTAGTGGTGACCAACAAGGGGCGAACCAAGCT GCCACCGGGGGTGGATCGGATGCGGCTTGAGAGGCATCTGTCTGCCGAGGACTTCTCAAG GGTATTTGCCATGTCCCCTGAAGAGTTTGGCAAGCTGGCTCTGTGGAAGCGGAATGAGCT CAAGAAGAAGGCCTCTCTCTTCTGATGGCCCCCACCTGCTCCGGGACGGCCCCCTTACCC CTGCTGCTTCAGGGTTTTTCCCCGGCGGGTTGGGAGGGGCAGGAGGTGGGGTGGAAATAG GGTGGGCTCCTTTCCTCAGGTAGAGTGGGGGGCCAAAACCTCTGCAGTCCCCGGCAGTGA GCTATGGACTTTCTTCCCCCTCACAAGGCTGGGGGCCTCCTGCTCTCGTCCCTGGCCCTC CCTGCACAGGGCAAAGCCAGTCTGGGCTCTGGCACACAGAGTTCATGTTTGCGCCCTCTC CCTGCCCCTCACCCCAGAGGGTGAGGAGGAATGAGGGGCATTGGTGGTTAGGCCGGTTGG CTGTCTTGAACAGCTGGAGGGAAGATGCAGGGGTGGGAAGCGGCCAGGCAGAAAGAGCTC CAGGCTCTTGTGTCGCCCACCCAGCCCTCCCATACTCACTCCTGACAGCTTTCCTGCACT GCAGCTTCCTGCTCCTCTGACTCTAGTGGGAACAGGCCCCAGCTCAGCCTCCGGCAGGGA GGTCACCCCTCCACTTCAGCTTGCCCTGACCTCCGCTCGCAAACCCCGAGCTTCCAAGCC TTTTGCTCCAGCCCTGCGGCTTCCCCAGAAGCCTGGGCTTAGGGTGGAGATGCCGCCTAC ACACGATCCTGGCCCTCCACCTGCCTCCAGGCCACGAAATGGGAATTCCAGCACTAAGCC AGGCACCGGGCAGAAGCTGGGCCTTCCGCCTCCCTTGGATGGGGTCAAGAGGCCAGGCCT GGCACATTTTGGAGTGTCCTGGCTACCAGCTCTCACCTACACCCACGCACCCCCCCACAC ACTATGCTCTCTCAAGAATGTAATTTATTGGGGCCCCCCCAGCTGCTTTCCTCACCTGCC CCTGCCCTACCTTACACCCCCAGCTTGACTTCTTTCCAGTCCACGTGTGTATATAATGAT ATCTATATTTTTGCCCAGGTCTGGGTATTGCTCCTGCCCAGACCCTGACATCCCTTTCCA CTGTGTGTGTGACCATGCTGGGGGAGGGGGACTCTGCTTGGAATTAAAAGGTTGCATTGG GTCCCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC052805 unedited GTCAAATATTTGTATACGACTCACTATAGGCGGACCGCGAATTCGCACGAGGGTGACCTT GTGGGGAAAGGAGCCAAGAACGGGGCGTCGGGGGGCCTGGGACCCCCCTGCCTGAGAGAT ACAGGAATCCTGGCCCCGTGTTGTGGACACAAGCGCCCATCCTCAAGGTCCTGAGAACTC CTGAACTTCCAAAGCCTGGAGAGTCACCGCCGAGGGATGAGGACGCGCCAGCCCGGGGGA ACGCGCCAGCTGCTTTCGCGGCCCCAAGCGCGCAGTGCCCAGCAGCCGCGCCGAGCCTGA CACGCTGTCCTCTCCCCTCGCGCACAGGGCTCTGCGAGTGACCCGGCGGGCGAGCTCCGT GCTGCATGGAACGGCTGCAGAAGCAACCACTTACCTCCCCCGGGAGCGTGAGCCCCTCCC GAGATTCCAGTGTGCCTGGCTCTCCCTCCAGCATCGTGGCCAAGATGGACAATCAGGTGC TGGGCTACAAGGACCTGGCTGCCATCCCCAAGGACAAGGCCATCCTGGACATCGAGCGGC CCGACCTCATGATCTACGAGCCTCACTTTACTTATTCCCTCCTGGAACACGTGGAGCTGC CTCGCAGCCGCGAGCGCTCGCTGTCACCCAAATCCACATCCCCCCCACCATCCCCAGAGG TGTGGGCGGACAGCCGGTCGCCTGGAATCATCTCTCAGGCCTCGGCCCCCAGAACCACTG GAACCCCCCGGACCAGCCTGCCCCATTTCCACCACCCTGAGACCTCCCGCCCAGATTCCA CATCTACAAGAAGCCTCCCATCTATAAGCAGAGAGAGTCCGTGGGAGGCAGCCCTCAGAC CAGGCACTCATCGAGGATCTCATCATCGAGTCATCCCAGTTTCCTGCAGCCCACCCCCAG ACCCCAACAGCCAGCCAAAATCGAAACCGCTACTGGCCATGCCCCCA
Restriction Sites	Please inquire
ACCN	BC052805
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC052805.1, AAH52805.1
RefSeq Size	2579 bp
Locus ID	2039
Gene Summary	The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

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