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Silencer of Death Domain (BAG4) (NM_004874) Human Untagged Clone
CAT＃: SC125513
BAG4 (untagged)-Human BCL2-associated athanogene 4 (BAG4), transcript variant 1
CNY 3,656.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BAG-4; SODD |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC125513 sequence for NM_004874 edited (data generated by NextGen Sequencing)
ATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTAC TACGGGCCTGGGGGTGGAGATGTGCCGGTACACCCACCTCCACCCTTATATCCTCTTCGC CCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGCCCGGCGGAGACC ACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCA GAGCCTGGTCGAGCCGGAGGAAGCCACCAGGAGCAGCCACCATATCCTAGCTACAATTCT AACTATTGGAATTCTACTGCGAGATCTAGGGCTCCTTACCCAAGTACATATCCTGTAAGA CCAGAATTGCAAGGCCAGAGTTTGAATTCTTATACAAATGGAGCGTATGGTCCAACATAC CCCCCAGGCCCTGGGGCAAATACTGCCTCATACTCAGGGGCTTATTATGCACCTGGTTAT ACTCAGACCAGTTACTCCACAGAAGTTCCAAGTACTTACCGTTCATCTGGCAACAGCCCA ACTCCAGTCTCTCGTTGGATCTATCCCCAGCAGGACTGTCAGACTGAAGCACCCCCTCTT AGGGGGCAGGTTCCAGGATATCCGCCTTCACAGAACCCTGGAATGACCCTGCCCCATTAT CCTTATGGAGATGGTAATCGTAGTGTTCCACAATCAGGACCGACTGTACGACCACAAGAA GATGCGTGGGCTTCTCCTGGTGCTTATGGAATGGGTGGCCGTTATCCCTGGCCTTCATCA GCGCCCTCAGCACCACCCGGCAATCTCTACATGACTGAAAGTACTTCACCATGGCCTAGC AGTGGCTCTCCCCAGTCACCCCCTTCACCCCCAGTCCAGCAGCCCAAGGATTCTTCATAC CCCTATAGCCAATCAGATCAAAGCATGAACCGGCACAACTTTCCTTGCAGTGTCCATCAG TACGAATCCTCGGGGACAGTGAACAATGATGATTCAGATCTTTTGGATTCCCAAGTCCAG TATAGTGCTGAGCCTCAGCTGTATGGTAATGCCACCAGTGACCATCCCAACAATCAAGAT CAAAGTAGCAGTCTTCCTGAAGAATGTGTACCTTCAGATGAAAGTACTCCTCCGAGTATT AAAAAAATCATACATGTGCTGGAGAAGGTCCAGTATCTTGAACAAGAAGTAGAAGAATTT GTAGGAAAAAAGACAGACAAAGCATACTGGCTTCTGGAAGAAATGCTAACCAAGGAACTT TTGGAACTGGATTCAGTTGAAACTGGGGGCCAGGACTCTGTACGGCAGGCCAGAAAAGAG GCTGTTTGTAAGATTCAGGCCATACTGGAAAAATTAGAAAAAAAAGGATTATGA Clone variation with respect to NM_004874.3 >OriGene 5' read for NM_004874 unedited
GCGCCCCAACCCCCCCCNCACCCGCNCGGTTCAAATTTGTATACGACTCATATAGGCGGC CGCGNAATTCGCACCAGGATCCCTGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGA CGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGAGATGTGCCGGTACACCCACC TCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCG CGGGGGCGGCCCGGCGGAGACCACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTA TCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGAGGAAGCCACCAGGAGCAGCC ACCATATCCTAGCTACAATTCTAACTATTGGAATTCTACTGCGAGATCTAGGGCTCCTTA CCCAAGTACATATCCTGTAAGACCAGAATTGCAAGGCCAGAGTTTGAATTCTTATACAAA TGGAGCGTATGGTCCAACATACCCCCCAGGCCCTGNGGCAAATACTGCCTCATACTCAGG GGCTTATTATGCACCTGGTTATACTCAGACCAGTTACTCCACAGAAGTTCCAAGTACTTA CCGTTCATCTGGCAACAGCCCAACTCCAGTCTCTCGTTGGATCTATCCCCAGCAGGACTG TCAGACTGAAGCACCCCCTCTTAGGGGGCANNGTTCAGGATATCCGCCTTCACAGAACCC TGGAATGACCCTGCCCCATATCCCTATGGAGATGGTAATCGTAGTGGTTCACAATCCAGA CCGACTGTTCGACCCCAAGAAGAGCCTGGGCTTCTCCTGGTGCTAATGGAAGGGGGCCCG TATCCCTGGCCTTTATAAGGCCCTCAGCACCACCCGGAATCTTTACATGACTGAAAGTAC TTCCCATGGGCCTACAAGGGNTCTTTCCCAATCCCCCCTTAACCCCAATCCAGAGGCCCA GGATCTTTCTTCCCTTTTGGCCATTATATCAAGCTTGACCCGGCCAACTTTCCTGGAGGG GTCATAAAAN |
| Restriction Sites | NotI-NotI |
| ACCN | NM_004874 |
| Insert Size | 5050 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_004874.2, NP_004865.1 |
| RefSeq Size | 2182 bp |
| RefSeq ORF | 1374 bp |
| Locus ID | 9530 |
| UniProt ID | O95429 |
| Domains | BAG |
| Protein Families | Druggable Genome |
| Gene Summary | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Hypermutation induced by APOBEC-1 overexpression can be eliminated
,Zhigang Chen, Thomas L. Eggerman, Alexander V. Bocharov, Irina N. Baranova, Tatyana G. Vishnyakova, Gyorgy Csako, and Amy P. Patterson,
RNA, May 2010; 16: 1040 - 1052
[BAG4]
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Other Versions
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|---|---|---|---|
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| RC206235L4 | Lenti ORF clone of Human BCL2-associated athanogene 4 (BAG4), transcript variant 1, mGFP tagged |
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| RG206235 | BAG4 (tGFP-tagged) - Human BCL2-associated athanogene 4 (BAG4), transcript variant 1 |
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