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EPO (NM_000799) Human Untagged Clone
CAT＃: SC125341
EPO (untagged)-Human erythropoietin (EPO)
CNY 2,400.00
CNY 3,990.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DBAL; ECYT5; EP; MVCD2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC125341 sequence for NM_000799 edited (data generated by NextGen Sequencing)
ATGGGGGTGCACGAATGTCCTGCCTGGCTGTGGCTTCTCCTGTCCCTGCTGTCGCTCCCT CTGGGCCTCCCAGTCCTGGGCGCCCCACCACGCCTCATCTGTGACAGCCGAGTCCTGGAG AGGTACCTCTTGGAGGCCAAGGAGGCCGAGAATATCACGACGGGCTGTGCTGAACACTGC AGCTTGAATGAGAATATCACTGTCCCAGACACCAAAGTTAATTTCTATGCCTGGAAGAGG ATGGAGGTCGGGCAGCAGGCCGTAGAAGTCTGGCAGGGCCTGGCCCTGCTGTCGGAAGCT GTCCTGCGGGGCCAGGCCCTGTTGGTCAACTCTTCCCAGCCGTGGGAGCCCCTGCAGCTG CATGTGGATAAAGCCGTCAGTGGCCTTCGCAGCCTCACCACTCTGCTTCGGGCTCTGGGA GCCCAGAAGGAAGCCATCTCCCCTCCAGATGCGGCCTCAGCTGCTCCACTCCGAACAATC ACTGCTGACACTTTCCGCAAACTCTTCCGAGTCTACTCCAATTTCCTCCGGGGAAAGCTG AAGCTGTACACAGGGGAGGCCTGCAGGACAGGGGACAGATGA Clone variation with respect to NM_000799.2 >OriGene 5' read for NM_000799 unedited
GACCTACTATATGGCGGCCGCGAATTCGAGATGGGGGTGCACGAATGTCCTGCCTGGCTG TGGCTTCTCCTGTTCCTGCTGTCGCTCCCTCTGGGCCTCCCAGTCCTGGGCGCCCCACCA CGCCTCATCTGTGACAGCCGAGTCCTGGAGAGGTACCTCTTGGAGGCCAAGGAGGCCGAG AATATCACGACGGGCTGTGCTGAACACTGCAGCTTGAATGAGAATATCACTGTCCCAGAC ACCAAAGTTAATTTCTATGCCTGGAAGAGGATGGAGGTCGGGCAGCAGGCCGTAGAAGTC TGGCAGGGCCTGGCCCTGCTGTCGGAAGCTGTCCTGCGGGGCCAGGCCCTGTTGGTCAAC TCTTCCCAGCCGTGGGAGCCCCTGCAGCTGCATGTGGATAAAGCCGTCAGTGGCCTTCGC AGCCTCACCACTCTGCTTCGGGCTCTGGGAGCCCAGAAGGAAGCCATCTCCCCTCCAGAT GCGGCCTCAGCTGCTCCACTCCGAACAATCACTGCTGACACTTTCCGCAAACTCTTCCGA GTCTACTCCAATTTCCTCCGGGGAAAGCTGAAGCTGTACACAGGGGAGGCCTGCATGACA GGGGACAGATGACCAGGCTCGACTCTAGATTGCGGCCGCGGTCATAGCTGTTTCCTGAAC AGATCCCCGGTGGGATTCCTGGTGACCCCTCCCCAGTGCCTTTTCGGGCCCTGGAAGTTG GCACTCCGTGGCCAACCAACCTGGCCTAATAAAATTAAATGCACCATTTGTCTGACAGGG G >OriGene 3' read for NM_000799 unedited
CCGTGGCGCATTGGNGATGGCACTTCCCAGGNCCGGNGAAAGCACTGGGGNAGTGGGTCA CAGGGCATGCCACCCGGGTTCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAG TCGAGCCTGGTCATCTGTCCCCTGTCCTGCAGGCCTCCCCTGTGTACAGCTTCAGCTTTC CCCGGAGGAAATTGGAGTAGACTCGGAAGAGTTTGCGGAAAGTGTCAGCAGTGATTGTTC GGAGTGGAGCAGCTGAGGCCGCATCTGGAGGGGAGATGGCTTCCTTCTGGGCTCCCAGAG CCCGAAGCAGAGTGGTGAGGCTGCGAAGGCCACTGACGGCTTTATCCACATGCAGCTGCA GGGGCTCCCACGGCTGGGAAGAGTTGACCAACAGGGCCTGGCCCCGCANGACAGCTTCCG ACAGCAGGGCCAGGCCCTGCCAGACTTCTACGGCCTGCTGCCCGACCTCCATCCTCTTCC AGGCATAGAAATTAACTTTGGTGTCTGGGACAGTGATATTCTCATTCAAGCTGCAGTGTT CAGCACAGCCCGTCGTGATATTCTCGGCCTCCTTGGCCTNCAAGAGGTACCTCTCCANGA CTCGGCTGTCACAGATGAGGCGTGGTGGGGCGCCCAGNACTGGGAGGCCCAGAGGGAGCG ACAGCAGGGACAAGAGAAGCACAGCCAGGCAGGACATTCGTGCACCCCCATCTCGAATTC GCGGCCCGCCTATAGTGAGTCGTATTACAAAATTCTGACGGTTCACTAAACGAGCTCTGC TTATTTTAGACCTCCAACCGTCACGCCTACCGGCCATTTTCCGTTCACGGGGCCGGGNTT ATTACAACATTTTGGGAAAGTCCCTTTGATTTTGGTGCCCAAAACAAACTCCCCTTGTCC TTCAAGGGGGTTGAAAACTA |
| Restriction Sites | Please inquire |
| ACCN | NM_000799 |
| Insert Size | 640 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000799.2, NP_000790.2 |
| RefSeq Size | 1340 bp |
| RefSeq ORF | 582 bp |
| Locus ID | 2056 |
| UniProt ID | P01588 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway |
| Gene Summary | This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Safety and angiogenic effects of systemic gene delivery of a modified erythropoietin
,de Lucas Cerrillo, AM;Bond, WS;Rex, TS;,
Gene Ther.
,PubMed ID 25716531
[EPO]
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