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BCAR1 (NM_014567) Human Untagged Clone
CAT＃: SC125332
BCAR1 (untagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6
CNY 6,376.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CAS; CAS1; CASS1; CRKAS; P130Cas |
| Vector | pCMV6-XL6 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC125332 sequence for NM_014567 edited (data generated by NextGen Sequencing)
ATGAACCACCTGAACGTGCTGGCCAAAGCGCTCTATGACAATGTGGCCGAGTCCCCGGAT GAGCTCTCCTTCCGCAAGGGTGACATCATGACGGTGCTGGAGCAGGACACGCAGGGCCTG GACGGCTGGTGGCTCTGCTCGCTGCATGGGCGCCAGGGCATCGTGCCTGGGAACCGCCTC AAGATCTTGGTGGGCATGTATGATAAGAAGCCAGCAGGGCCTGGCTCCGGCCCTCCCGCC ACCCCGGCCCAGCCTCAGCCTGGCCTCCATGCCCCAGCGCCTCCGGCCTCCCAGTACACG CCCATGCTCCCCAACACCTACCAGCCCCAGCCAGACAGCGTCTACCTGGTGCCCACTCCC AGCAAGGCTCAGCAAGGCCTCTACCAAGTCCCGGGTCCCAGCCCTCAGTTCCAGTCTCCC CCAGCCAAGCAGACATCCACCTTCTCGAAGCAGACACCCCATCACCCGTTTCCCAGCCCG GCCACAGACCTGTACCAGGTGCCCCCAGGGCCTGGAGGCCCTGCCCAGGATATTTACCAG GTGCCACCTTCTGCCGGGATGGGGCATGACATCTACCAGGTCCCCCCGTCCATGGACACA CGCAGCTGGGAGGGCACGAAGCCCCCGGCAAAGGTGGTGGTGCCCACCCGCGTGGGGCAG GGCTATGTATACGAGGCCGCCCAGCCGGAGCAGGACGAGTACGACATCCCGCGACACCTG CTGGCCCCGGGGCCACAGGACATCTATGATGTGCCCCCGGTTCGGGGGCTGCTTCCCAGC CAGTATGGCCAGGAGGTGTATGACACACCCCCCATGGCTGTCAAGGGTCCCAATGGCCGA GACCCGTTGCTGGAGGTGTATGACGTGCCCCCCAGTGTGGAGAAGGGCCTGCCACCGTCC AATCACCACGCAGTCTACGACGTTCCTCCATCGGTGAGCAAGGATGTGCCCGATGGCCCA CTGCTGCGTGAGGAGACCTACGATGTGCCCCCCGCCTTCGCCAAGGCCAAGCCCTTTGAC CCGGCCCGCACCCCACTGGTACTGGCTGCGCCCCCTCCAGACTCCCCGCCGGCCGAGGAC GTGTATGACGTGCCGCCCCCGGCTCCTGACCTCTACGACGTGCCCCCTGGCTTGCGGCGG CCTGGCCCGGGCACCCTGTACGATGTGCCCCGTGAACGGGTGCTTCCTCCTGAGGTGGCT GATGGTGGCGTGGTCGACAGTGGTGTGTATGCGGTGCCTCCCCCAGCTGAACGTGAAGCC CCGGCAGAGGGCAAGCGCCTGTCGGCCTCCAGCACCGGCAGCACACGCAGCAGCCAGTCT GCGTCCTCCTTGGAGGTGGCAGGGCCGGGCCGGGAACCCCTGGAGCTGGAAGTTGCTGTG GAGGCCCTGGCACGGCTGCAGCAGGGTGTGAGCGCCACCGTTGCCCACCTTCTGGACCTG GCAGGCAGCGCCGGTGCGACTGGGAGCTGGCGTAGCCCCTCTGAGCCACAGGAGCCGCTG GTGCAGGACCTGCAGGCTGCTGTGGCCGCCGTCCAGAGTGCCGTCCACGAGCTGTTGGAG TTTGCCCGCAGCGCGGTGGGCAATGCTGCCCACACATCTGACCGTGCCCTGCATGCCAAG CTTAGCCGGCAGCTGCAGAAGATGGAGGACGTGCACCAGACGCTGGTGGCACATGGTCAG GCCCTCGACGCTGGCCGGGGAGGCTCTGGAGCCACCCTTGAGGACCTGGACCGGCTGGTG GCCTGCTCGCGGGCTGTGCCCGAGGACGCCAAGCAGCTGGCCTCCTTCCTGCACGGCAAT GCCTCACTGCTCTTCAGACGGACCAAGGCCACTGCCCCGGGGCCTGAGGGGGGTGGCACC CTGCACCCCAACCCCACTGACAAGACCAGCAGCATCCAGTCACGACCCCTGCCCTCACCC CCTAAGTTCACCTCCCAGGACTCGCCAGATGGGCAGTACGAGAACAGCGAGGGGGGCTGG ATGGAGGACTATGACTACGTCCACCTACAGGGGAAGGAGGAGTTTGAGAAGACCCAGAAG GAGCTGCTGGAAAAGGGCAGCATCACGCGGCAGGGCAAGAGCCAGCTGGAGTTGCAGCAG CTGAAGCAGTTTGAACGACTGGAACAGGAGGTGTCACGGCCCATAGACCACGACCTGGCC AACTGGACGCCAGCCCAACCCCTGGCCCCGGGGCGAACAGGCGGCCTGGGGCCCTCGGAC CGGCAGCTGCTGCTCTTCTACCTGGAGCAGTGTGAGGCCAACCTGACCACACTGACCAAC GCCGTGGACGCCTTCTTTACCGCCGTGGCCACCAACCAGCCGCCCAAGATCTTTGTGGCG CACAGCAAGTTCGTCATCCTCAGCGCCCACAAGCTGGTGTTCATCGGGGACACACTGTCA CGGCAGGCCAAGGCTGCTGACGTGCGCAGCCAGGTGACCCACTACAGCAACCTGCTGTGC GACCTCCTGCGCGGCATCGTGGCCACCACCAAGGCCGCTGCCTTGCAGTACCCATCGCCT TCCGCGGCCCAGGACATGGTGGAGAGGGTCAAGGAGCTGGGCCACAGCACCCAGCAGTTC CGCCGCGTCCTAGGCCAGCTGGCAGCCGCCTGA Clone variation with respect to NM_014567.3 226 c=>t;903 c=>t;1530 t=>c >OriGene 5' read for NM_014567 unedited
CCCCCGCCCCGTTGCCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAG AGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAA TTCGGCACGAGGCTCTGGGTGGCCGAGGCGGCAGCTGCGCGGCGGCACCGGGGCGGCTGC GGCGCGCTCGGAGCCCCGAGGGCACGCGGCCCGGGCAGCTCGGTGTGCGCCCCCGCGAGA GCCGGGGCCCCAGGCCCGCCGGACACCATGAACCACCTGAACGTGCTGGCCAAAGCGCTC TATGACAATGTGGCCGAGTCCCCGGATGAGCTCTCCTTCCGCAAGGGTGACATCATGACG GTGCTGGAGCAGGACACGCAGGGCCTGGACGGCTGGTGGCTCTGCTCGCTGCATGGGCGC CAGGGCATCGTGCCTGGGAACCGCCTCAAGATCTTGGTGGGCATGTATGATAAGAAGCCA GCAGGGCCTGGCTCCGGCCCTCCCGCCACCCCGGCCCAGCCTCAGCCTGGCCTCCATGCC CCAGCGCCTCCGGCCTCCCAGTACACGCCCATGCTCCCCAACACCTACCAGCCCCAGCCA GACAGCGTCTACCTGGTGCCCACTCCCAGCAAGGCTCAGCAAGGCCTCTACCAAGTCCCG GGTCCCAGCCCTCAGTTCCAGTCTCCCCCAGCCAAGCAGACATCCACCTTCTCGAAGCAG ACACCCCATCACCCGTTTCCCAGCCCGCCACAGACCTGTACCAGTGCCCCCAGGCCCTGN AGGGCCTGCCCAGGATATTACCCAGTGCCCACTCTGCCGGATGGGGCATGACTCTACCAG TCCCCCGTCCATGACACCGCAGCTGGAGGGCACGAACCCCGCCAAGTGGTGGTGCCACCC CGTGGGCAGGCTATGATACCAGCCGCCCAGCG >OriGene 3' read for NM_014567 unedited
TTTTGCCAAATTTGGACCGCGCCGCATTCTANATCGAGTTTTTTTTTTTTTTTTTTCCTT TTAAAAACTTTATTTAAATGGAGACTCTTAGTCAAATGATTGGAAAACCAATAACGAAAA ATAGTTCTTCAGGTTCTTCTCCTGGAAAGGCGGAGGACACACCAAACTGCACTGGCCCTG TCAGGGGACACGGCACCCTCGTGGGACCAGGCTCAGCCCTCGGGGTGGCACGAGGTCCTG CAGGCTGCAGGACCCTCACACTCCAGCCCCGTCTGGTGACCCAACCCGGGCCCGTGGTGC ATGCTGGAGAAGGCCACTGGCCGGCCCCTGGGCTTCGGCTCCTGAGGAGGCATGGCCCCA CACCCTGCCCGGCCATAAATATATACAGATTCCTGGGCATCCAGGGCACCAGGACCGACG CAGAGCTGGGGTCCTGTCCCTAAGCCTGTGGCACAGCGACTCTTGACATGGGAGCCAGGG AGCTGGGACCGCCGCACCCCTCCCCTGCCTCCCTCCTGGGGTCACCACCCTCAGGCGGCT GCCAGCTGGCCTAGGACGCGGCGGAACTGCTGGGTGCTGTGGCCCAGCTCCTTGACCCTC TCCACCATGTCCTGGGCCGCGGAAGGCGATGGGTACTGCAAGGCAGCGGCCTTGGTGGTG GCCACGATGCCGCGCAGGAGGTCGCACAGCAGGTTGCTGTAGTGGGTCACCTGGCTGCGC ACGTCAGCAGCCTTGGCCTGCCGTGACAGTGTGTCCCCGATGAACACCAGCTTGTGGGCG CTGAGGATGACGAACTTGCTGTGCGCCACANAGATCTTGGGCGGCTGGTTGGTGGCCACG GCGGTAAAGAAGGCGTCCACGGCGTTGGTCAGTGTGA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_014567 |
| Insert Size | 3500 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_014567.2, NP_055382.2 |
| RefSeq Size | 3241 bp |
| RefSeq ORF | 2613 bp |
| Locus ID | 9564 |
| UniProt ID | P56945 |
| Domains | SH3, Extensin_2 |
| Protein Families | Druggable Genome |
| Protein Pathways | Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton |
| Gene Summary | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] Transcript Variant: This variant (6) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (6) is shorter and has a different N-terminus, as compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209133 | BCAR1 (Myc-DDK-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6 |
CNY 6,376.00 |
|
| RC209133L1 | Lenti-ORF clone of BCAR1 (Myc-DDK-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6 |
CNY 8,776.00 |
|
| RC209133L2 | Lenti-ORF clone of BCAR1 (mGFP-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6 |
CNY 9,030.00 |
|
| RC209133L3 | Lenti-ORF clone of BCAR1 (Myc-DDK-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6 |
CNY 9,030.00 |
|
| RC209133L4 | Lenti-ORF clone of BCAR1 (mGFP-tagged)-Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6 |
CNY 9,030.00 |
|
| RG209133 | BCAR1 (tGFP-tagged) - Human breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6 |
CNY 7,976.00 |
