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Desmocollin 2 (DSC2) (NM_024422) Human Untagged Clone
CAT＃: SC124977
DSC2 (untagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2a
CNY 9,904.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ARVD11; CDHF2; DG2; DGII/III; DSC3 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC124977 sequence for NM_024422 edited (data generated by NextGen Sequencing)
ATGGAGGCAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTG ACCCTCGCGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCC TCCAAACTAGATGCCGAGAAACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCT GCAAATCTAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTAT ACAACAAATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAAC ACTGAGAACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTCCTA AAGAAAAGACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATT CCTTGTTCGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAA TCTGACACGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAA GAACCTCGGAATTTATTTTATGTGGAGAGAGACACTGGAAACTTGTATTGTACTCGTCCT GTAGATCGTGAGCAGTATGAATCTTTTGAGATAATTGCCTTTGCAACAACTCCAGATGGG TATACTCCAGAACTTCCACTGCCCCTAATAATCAAAATAGAGGATGAAAATGATAACTAC CCAATTTTTACAGAAGAAACTTATACTTTTACAATTTTTGAAAATTGCAGAGTGGGCACT ACTGTGGGACAAGTGTGTGCTACTGACAAAGATGAGCCTGACACGATGCACACACGCCTG AAGTACTCCATCATTGGGCAGGTGCCACCATCACCCACCCTATTTTCTATGCATCCAACT ACAGGCGTGATCACCACAACATCATCTCAGCTAGACAGAGAGTTAATTGACAAGTACCAG TTGAAAATAAAAGTACAAGACATGGATGGTCAGTATTTTGGTCTACAGACAACTTCAACT TGTATCATTAACATTGATGATGTAAATGACCACTTGCCAACATTTACTCGTACTTCTTAT GTGACATCAGTGGAAGAAAATACAGTTGATGTGGAAATCTTACGAGTTACTGTTGAGGAT AAGGACTTAGTGAATACTGCTAACTGGAGAGCTAATTATACCATTTTAAAGGGCAATGAA AATGGCAATTTTAAAATTGTAACAGATGCCAAAACCAATGAAGGAGTTCTTTGTGTAGTT AAGCCTTTGAATTATGAAGAAAAGCAACAGATGATCTTGCAAATTGGTGTAGTTAATGAA GCTCCATTTTCCAGAGAGGCTAGTCCAAGATCAGCCATGAGCACAGCAACAGTTACTGTT AATGTAGAAGATCAGGATGAGGGCCCTGAGTGTAACCCTCCAATACAGACTGTTCGCATG AAAGAAAATGCAGAAGTGGGAACAACAAGCAATGGATATAAAGCATATGACCCAGAAACA AGAAGTAGCAGTGGCATAAGGTATAAGAAATTAACTGATCCAACAGGGTGGGTCACCATT GATGAAAATACAGGATCAATCAAAGTTTTCAGAAGCCTGGATAGAGAGGCAGAGACCATC AAAAATGGCATATATAATATTACAGTCCTTGCATCAGACCAAGGAGGGAGAACATGTACG GGGACACTGGGCATTATACTTCAAGACGTGAATGATAACAGCCCATTCATACCTAAAAAG ACAGTGATCATCTGCAAACCCACCATGTCATCTGCGGAGATTGTTGCGGTTGATCCTGAT GAGCCTATCCATGGCCCACCCTTTGACTTTAGTCTGGAGAGTTCTACTTCAGAAGTACAG AGAATGTGGAGACTGAAAGCAATTAATGATACAGCAGCACGTCTTTCCTATCAGAATGAT CCTCCATTTGGCTCATATGTAGTACCTATAACAGTGAGAGATAGACTTGGCATGTCTAGT GTCACTTCATTGGATGTTACACTGTGTGACTGCATTACCGAAAATGACTGCACACATCGT GTAGATCCAAGGATTGGCGGTGGAGGAGTACAACTTGGAAAGTGGGCCATCCTTGCAATA TTGTTGGGCATAGCATTGCTCTTTTGCATCCTGTTTACGCTGGTCTGTGGGGCTTCTGGG ACGTCTAAACAACCAAAAGTAATTCCTGATGATTTAGCCCAGCAGAACCTAATTGTATCA AACACAGAAGCTCCTGGAGATGACAAAGTGTATTCTGCGAATGGCTTCACAACCCAAACT GTGGGCGCTTCTGCTCAGGGAGTTTGTGGCACCGTGGGATCAGGAATCAAAAACGGAGGT CAGGAGACCATCGAAATGGTGAAAGGAGGACACCAGACCTCGGAATCCTGCCGGGGGGCT GGCCACCATCACACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGA TACACTTACTCGGAGTGGCACAGTTTTACTCAGCCCCGTCTTGGTGAAAAAGTGTATCTG TGTAATCAAGATGAAAATCACAAGCATGCCCAAGACTATGTCCTGACATATAACTATGAA GGAAGAGGATCGGTGGCTGGGTCTGTAGGTTGTTGCAGTGAACGACAAGAAGAAGATGGG CTTGAATTTTTGGATAATTTGGAGCCCAAATTTAGGACACTAGCAGAAGCATGCATGAAG AGATGA Clone variation with respect to NM_024422.3 >OriGene 5' read for NM_024422 unedited
GGCAGCAATTTGTAATACGACTCACTATAGGGCGGCCGCGAAATCGGCACCAGGNATGAG AGGCAGGCGCTTCAGAGAAGCTAAGAAAACACCTCTCCGCGCGCCCCACCTCCTCCGCCT CGCGCTCCTCCTGAGCAGCGGGCCCAGACTGCGCTCCGGCCGCGGCCCTCGCCCCGCGGA GCCCTCCTACCCCGGCCCGACGCTCGGCCCGCGACCTGCCCCGAGCCCTCTCCATGGAGG CAGCCCGCCCCTCCGGCTCCTGGAACGGAGCCCTCTGCCGGCTGCTCCTGCTGACCCTCG CGATCTTAATATTTGCCAGTGATGCCTGCAAAAATGTGACATTACATGTTCCCTCCAAAC TAGATGCCGAGAAACTTGTTGGTAGAGTTAACCTGAAAGAGTGCTTTACAGCTGCAAATC TAATTCATTCAAGTGATCCTGACTTCCAAATTTTGGAGGATGGTTCAGTCTATACAACAA ATACTATTCTATTGTCCTCGGAGAAGAGAAGTTTTACCATATTACTTTCCAACACTGAGA ACCAAGAAAAGAAGAAAATATTTGTCTTTTTGGAGCATCAAACAAAGGTCCTAAAGAAAA GACATACTAAAGAAAAAGTTCTAAGGCGCGCCAAGAGAAGATGGGCTCCAATTCCTTGTT CGATGCTAGAAAACTCCTTGGGTCCTTTTCCACTTTTCCTTCAACAGGTTCAATCTGACA CGGCCCAAAACTATACCATATACTATTCCATAAGAGGTCCTGGAGTTGACCAAGAACCTC GGAATTTATTTTATGTGGAGAGAGAACTGNNGAACTGTATTGTACTCGTCCTGTAGATCG TGAGCAGTATGAAATCTTTGAGATATNGCCCTTGCACAACTCAGATGGTATCTNCAGAAC TTCATGNCCNNTATATCAATAGAGATGAAATGATACTACCCATTTTACAGAGAAACTAAC TT >OriGene 3' read for NM_024422 unedited
GGGGCTACTCGGGTCCCGAACCCAAATAGTTTTTNCAATAACACCCAGCGCCAAACACCG GAATATATCGGAANGACACCAACAGTGGCCCTTAGTGGACCAAAAAGAATGACTGTCATG CTTCAAAAATAATTTTTATTGAAGTGACTTACACTGGAGCCTGATGAAACAAGTTCTGTT ATTATCCCCCATTTTAAAATGATGAAAATGGACTTATCAAAAGCAAGCAACTTAACCTTT AGGGGGGGGCCTCACAGCCTTTAGAATAGTCATATTATATAAATATGGCAATAACAATGC ACTGAAAATGTCTCCCAAACACACTCTACTCTTTTAAAAAATGTATAACAGGCAATCTAA GGAAGGGGTCTTACTTCTCTGATTCACGGAGTGCTAAATCCCTTAAACTCAAATCAGACC TGTGATGAGCAAGCTGCAACAAAGTTACAGAAACTGCTTAACTTACTTTATCATGGCCTA TTATTGTATACGAATTTCTTATTTACTTTACTAAACACAACTTTGGAAAACTAATTTAGG CTGTCCGGCATAAAACTTCCGGTAAGATAACCTGCTCACCACACAACTCCGTAGAGATAA CCTGGCCGACAATTGTTCGAACAGCGTCGGGGACCTTAACACCCGCCCCGTCGCCGCCGT TCAAATAAGTAGGAGCCGCTTTAACCTCTGCCTTATGTTCACTATAAATAGAAAACTCTT TGCACCACCATTCTCGCGAAACATCGCCCGGACCTATCGCGAGCCGCCACGCGAACGTTC GATTCACGCGCCCACCAGTCACAGCGTTGGCCGCCGTGCCCCCGCGTCTCTTCGCTGCAG TCTAAGACGAAATCCACAGCCGTCACCCCCGCCCCGGCCCCACACCACCCATCCCA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_024422 |
| Insert Size | 4700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_024422.2, NP_077740.1 |
| RefSeq Size | 5140 bp |
| RefSeq ORF | 2706 bp |
| Locus ID | 1824 |
| UniProt ID | Q02487 |
| Domains | CA |
| Protein Families | Transmembrane |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| Gene Summary | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] Transcript Variant: This variant (Dsc2a, also known as DGII) encodes the longer isoform (Dsc2a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209218 | DSC2 (Myc-DDK-tagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2a |
CNY 9,896.00 |
|
| RC209218L1 | Lenti-ORF clone of DSC2 (Myc-DDK-tagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2a |
CNY 9,030.00 |
|
| RC209218L2 | Lenti-ORF clone of DSC2 (mGFP-tagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2a |
CNY 9,030.00 |
|
| RC209218L3 | Lenti-ORF clone of DSC2 (Myc-DDK-tagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2a |
CNY 9,030.00 |
|
| RC209218L4 | Lenti-ORF clone of DSC2 (mGFP-tagged)-Human desmocollin 2 (DSC2), transcript variant Dsc2a |
CNY 9,030.00 |
|
| RG209218 | DSC2 (tGFP-tagged) - Human desmocollin 2 (DSC2), transcript variant Dsc2a |
CNY 7,890.00 |
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