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KCNH2 (NM_172057) Human Untagged Clone
CAT＃: SC124103
KCNH2 (untagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 3
CNY 9,008.00
货期*
现货
规格
| Cited in 1 publication. |
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ERG-1; ERG1; H-ERG; HERG; HERG1; Kv11.1; LQT2; SQT1 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC124103 sequence for NM_172057 edited (data generated by NextGen Sequencing)
ATGGCGGCCCCAGCCGGGAAGGCGAGCAGGACAGGGGCTCTGCGGCCCAGGGCCCAGAAA GGCCGGGTGAGGCGGGCCGTGCGCATCTCCAGCCTCGTGGCCCAGGAGGTCCTGTCCCTG GGCGCCGACGTGCTGCCTGAGTACAAGCTGCAGGCACCGCGCATCCACCGCTGGACCATC CTGCATTACAGCCCCTTCAAGGCCGTGTGGGACTGGCTCATCCTGCTGCTGGTCATCTAC ACGGCTGTCTTCACACCCTACTCGGCTGCCTTCCTGCTGAAGGAGACGGAAGAAGGCCCG CCTGCTACCGAGTGTGGCTACGCCTGCCAGCCGCTGGCTGTGGTGGACCTCATCGTGGAC ATCATGTTCATTGTGGACATCCTCATCAACTTCCGCACCACCTACGTCAATGCCAACGAG GAGGTGGTCAGCCACCCCGGCCGCATTGCCGTCCACTACTTCAAGGGCTGGTTCCTCATC GACATGGTGGCCGCCATCCCCTTCGACCTGCTCATCTTTGGCTCTGGCTCTGAGGAGCTG ATCGGGCTGCTGAAGACTGCGCGGCTGCTGCGGCTGGTGCGCGTGGCGCGGAAGCTGGAT CGCTACTCAGAGTACGGCGCGGCCGTGCTGTTCTTGCTCATGTGCACCTTTGCGCTCATC GCGCACTGGCTGGCCTGCATCTGGTACGCCATCGGCAACATGGAGCAGCCACACATGGAC TCACGCATCGGCTGGCTGCACAACCTGGGCGACCAGATAGGCAAACCCTACAACAGCAGC GGCCTGGGCGGCCCCTCCATCAAGGACAAGTATGTGACGGCGCTCTACTTCACCTTCAGC AGCCTCACCAGTGTGGGCTTCGGCAACGTCTCTCCCAACACCAACTCAGAGAAGATCTTC TCCATCTGCGTCATGCTCATTGGCTCCCTCATGTACGCTAGCATCTTCGGCAACGTGTCG GCCATCATCCAGCGGCTGTACTCGGGCACAGCCCGCTACCACACACAGATGCTGCGGGTG CGGGAGTTCATCCGCTTCCACCAGATCCCCAATCCCCTGCGCCAGCGCCTCGAGGAGTAC TTCCAGCACGCCTGGTCCTACACCAACGGCATCGACATGAACGCGGTGCTGAAGGGCTTC CCTGAGTGCCTGCAGGCTGACATCTGCCTGCACCTGAACCGCTCACTGCTGCAGCACTGC AAACCCTTCCGAGGGGCCACCAAGGGCTGCCTTCGGGCCCTGGCCATGAAGTTCAAGACC ACACATGCACCGCCAGGGGACACACTGGTGCATGCTGGGGACCTGCTCACCGCCCTGTAC TTCATCTCCCGGGGCTCCATCGAGATCCTGCGGGGCGACGTCGTCGTGGCCATCCTGGGG AAGAATGACATCTTTGGGGAGCCTCTGAACCTGTATGCAAGGCCTGGCAAGTCGAACGGG GATGTGCGGGCCCTCACCTACTGTGACCTACACAAGATCCATCGGGACGACCTGCTGGAG GTGCTGGACATGTACCCTGAGTTCTCCGACCACTTCTGGTCCAGCCTGGAGATCACCTTC AACCTGCGAGATACCAACATGATCCCGGGCTCCCCCGGCAGTACGGAGTTAGAGGGTGGC TTCAGTCGGCAACGCAAGCGCAAGTTGTCCTTCCGCAGGCGCACGGACAAGGACACGGAG CAGCCAGGGGAGGTGTCGGCCTTGGGGCCGGGCCGGGCGGGGGCAGGGCCGAGTAGCCGG GGCCGGCCGGGGGGGCCGTGGGGGGAGAGCCCGTCCAGTGGCCCCTCCAGCCCTGAGAGC AGTGAGGATGAGGGCCCAGGCCGCAGCTCCAGCCCCCTCCGCCTGGTGCCCTTCTCCAGC CCCAGGCCCCCCGGAGAGCCGCCGGGTGGGGAGCCCCTGATGGAGGACTGCGAGAAGAGC AGCGACACTTGCAACCCCCTGTCAGGCGCCTTCTCAGGAGTGTCCAACATTTTCAGCTTC TGGGGGGACAGTCGGGGCCGCCAGTACCAGGAGCTCCCTCGATGCCCCGCCCCCACCCCC AGCCTCCTCAACATCCCCCTCTCCAGCCCGGGTCGGCGGCCCCGGGGCGACGTGGAGAGC AGGCTGGATGCCCTCCAGCGCCAGCTCAACAGGCTGGAGACCCGGCTGAGTGCAGACATG GCCACTGTCCTGCAGCTGCTACAGAGGCAGATGACGCTGGTCCCGCCCGCCTACAGTGCT GTGACCACCCCGGGGCCTGGCCCCACTTCCACATCCCCGCTGTTGCCCGTCAGCCCCCTC CCCACCCTCACCTTGGACTCGCTTTCTCAGGTTTCCCAGTTCATGGCGTGTGAGGAGCTG CCCCCGGGGGCCCCAGAGCTTCCCCAAGAAGGCCCCACACGACGCCTCTCCCTACCGGGC CAGCTGGGGGCCCTCACCTCCCAGCCCCTGCACAGACACGGCTCGGACCCGGGCAGTTAG Clone variation with respect to NM_172057.2 447 c=>t;519 c=>t;672 a=>g;936 t=>c >OriGene 5' read for NM_172057 unedited
GAGTCAGAATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGGGCACCCT GGCAGCAGGGCCCACGCCACGGGGCCATGGGCAGCTCGAGCCAGGCAGGCTGCTGCCCAC GCTTACTGCCAGGGTGACCCCAGCCCTGGGGCCCAGCCACAACCACCCTGGCTTCATGCC AGGGGCTGCTCTGGTTGCCAGTCGGCCAGCCTCGGGGGTGCAGCCTGGGCTGGGACTGCT GCTGGGGTGCAGGTGAGGCAGTGGCCGGGCCCTCAGGCCCCAGGGCAGGCAGGCTGCAGG GAGCCAAGTCCTCCATGGCGGCCCCAGCCGGGAAGGCGAGCAGGACAGGGGCTCTGCGGC CCAGGGCCCAGAAAGGCCGGGTGAGGCGGGCCGTGCGCATCTCCAGCCTCGTGGCCCAGG AGGTCCTGTCCCTGGGCGCCGACGTGCTGCCTGAGTACAAGCTGCAGGCACCGCGCATCC ACCGCTGGACCATCCTGCATTACAGCCCCTTCAAGGCCGTGTGGGACTGGCTCATCCTGC TGCTGGTCATCTACACGGCTGTCTTCACACCCTACTCGGCTGCCTTCCTGCTGAAGGAGA CGGAAGAAGGCCCGCCTGCTACCGAGTGTGGCTACGCCTGCCAGCCGCTGGCTGTGGTGG ACCTCATCGTGGACATCATGTTCATTGTGGACATCCTCATCAACTTCCGCACCACCTACG TCAATGCCAACGAGGAGGTGGTCAGCCAACCCGGCCGCATTGGCGTCCACTACTTCAGGG GCTGGTTTCTCATCGACATGGTGGCCGCCATCCCCTTCGAACTGCTTATCTTTGGCTCTG GGTCTTAAGACCTGATCGGGCCTGTGAAAAATGGCCCGCTGCTGCGGCTGGTGCCCCTGG CCCCGAAACTGAT >OriGene 3' read for NM_172057 unedited
AGTTTGCTGACAGGCAACCGCGGGGATGTGGAAGTGGGGCCAGGCCCCGGGGTGGTCACA GCTTTTTAGGCGGGCGGGACNNNNNAATGTGCCTCGGTAGCATCTGCAGGACAGTGGCCA TGTCTGCACTCAGCCGGGTCTCCAGCCTGTTGAGCTGGCGCTGGAGGGCATCCAGCCTGC TCTCCACGTCGCCCCGGGGCCGCCGACCCGGGCTGGAGAGGGGGATGTTGAGGAGGCTGG GGGTGGGGGCGGGGCATCGAGGGAGCTCCTGGTACTGGCGGCCCCGACTGTCCCCCCAGA AGCTGAAAATGTTGGACACTCCTGAGAAGGCGCCTGACAGGGGGTTGCAAGTGTCGCTGC TCTTCTCGCAGTCCTCCATCAGGGGCTCCCCACCCGGCGGCTCTCCGGGGGGCCTGGGGC TGGAGAAGGGCACCAGGCGGAGGGGGCTGGAGCTGCGGCCTGGGCCCTCATCCTCACTGC TCTCAGGGCTGGAGGGGCCACTGGACGGGCTCTCCCCCCACGGCCCCCCCGGCCGGCCCC GGCTACTCGGCCCTGGCCCCGCCCGGCCCGGCCCCAAGGCCGACACCCTCCCTGGGCTGC TTCCGTGTCCTTGGTCCGTGCGCCCTGCGGAAAGGACAAACTTGGCGCTTGGCGTTGCCG GACTGAAGCCCACCTCTTCTAACTCTCGTACCTGCCCGGGGGGAGACCCTCGGAATCATG GCTGGGTAATCCTCCGCAGGGTTTGCAAAGGCTGATCTTCCCAGGCCTGGGACTCAAGTA ATTGGGTTCCGAAGAAAATCTCG |
| Restriction Sites | Please inquire |
| ACCN | NM_172057 |
| Insert Size | 3300 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_172057.1, NP_742054.1 |
| RefSeq Size | 3191 bp |
| RefSeq ORF | 2460 bp |
| Locus ID | 3757 |
| UniProt ID | Q12809 |
| Domains | cNMP, ion_trans |
| Protein Families | Druggable Genome, Ion Channels: Potassium, Transcription Factors, Transmembrane |
| Gene Summary | This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (3), also known as HERG1b, differs in the 5' UTR and 5' coding region compared to variant 1, resulting in a shorter isoform (c) with a different N-terminus compared to isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
,Tay, YL;Amanah, A;Adenan, MI;Wahab, HA;Tan, ML;,
Sci Rep
,PubMed ID 31874991
[KCNH2]
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| RG216897 | KCNH2 (tGFP-tagged) - Human potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 3 |
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