Neurotensin Receptor 2 (NTSR2) (BC022501) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	levocabastine-sensitive neurotensin receptor; neurotensin receptor, type 2; neurotensin receptor 2; NTR2
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC022501 edited AGTGAGAGGGAGGGAGCGCCGGCCGCGGGAGCGGGATGGAAACCAGCAGCCCGCGGCCCC CGCGGCCCAGCTCCAACCCGGGGCTGAGCCTGGACGCCCGGCTGGGCGTGGACACTCGCC TCTGGGCCAAGGTGCTGTTCACCGCGCTCTACGCACTCATCTGGGCGCTGGGCGCGGCGG GCAATGCGCTGTCCGTGCACGTGGTGCTGAAGGCGCGGGCCGGGCGAGCGGGGCGCCTGC GCCACCACGTGCTCAGCCTGGCGCTCGCGGGCCTGCTGCTGCTGCTGGTCGGCGTGCCGG TGGAGCTCTACAGCTTCGTGTGGTTCCACTACCCCTGGGTCTTCGGCGACCTGGGCTGCC GCGGCTACTACTTCGTGCACGAGCTGTGCGCCTACGCCACGGTGCTGAGCGTGGCAGGCC TGAGCGCCGAGCGCTGCCTAGCCGTGTGCCAGCCCCTGCGTGCCCGCAGCCTGCTGACGC CACGCCGGACCCGGTGGCTGGTGGCGCTCTCGTGGGCCGCCTCGCTCGGCCTCGCCATGC CCATGGCCGTCATCATGGGGCAGAAGCACGAACTCGAGACGGCGGACGGGGAGCCGGAGC CCGCCTCGCGAGTGTGCACGGTGCTGGTGAGCCGCACCGCGCTCCAAGTCTTTATCCAGG TGAATGTGCTGGTGTCCTTCGTGCTCCCCTTGGCACTAACTGCTTTCCTGAATGGGGTCA CAGTGAGCCACCTGCTGGCCCTCTGCTCCCAAGTGCCGTCCACTTCTACCCCGGGCAGCT CCACCCCCAGCCGCCTGGAGCTGCTGAGTGAGGAGGGTCTCCTCAGCTTCATCGTATGGA AGAAGACCTTTATCCAGGGAGGCCAGGTCAGCCTGGTGAGACATAAAGACGTGCGCCGGA TCCGCAGCCTCCAGCGCAGCGTCCAGGTTCTCAGAGCCATCGTGGTCATGTATGTCATCT GCTGGCTGCCGTACCATGCCCGCAGGCTCATGTACTGCTACGTACCTGATGACGCGTGGA CTGACCCACTGTACAATTTCTACCACTACTTCTACATGGTGACCAACACACTTTTCTACG TCAGCTCAGCTGTGACTCCTCTTCTCTACAACGCCGTGTCCTCCTCCTTCAGAAGACTCT TCCTGGAAGCCGTCAGCTCCCTGTGTGGAGAGCACCACCCCATGAAGCGGTTACCCCCGA AGCCCCAGAGTCCCACCCTAATGGATACAGCTTCAGGCTTTGGGGATCCCCCAGAAACCC GGACCTGAATGTAATGCAAGAATGAACAGAACAAGCAAAATGACCAGCTGCTTAGTCACC TGGCAAAGCAGGTGAGCAACCTCATCACTAATCATTCAAGCTTCGCAGCCAGGGCGACTT CTATCAACCCCTGCTCTGCTGAGAACCATCAAGCGCAGGGAAGCCACGTGACCCCTCCTA GCCTCAGGCTCCCTCGTCTGTGTAGTGGAGATAAAGAACAGCACCCATCTCTTAGTGTTG CCTGAGACTAAAGTGCTTAGCACAGAACCTGGTGCGTAGTAGATGCTCAATAAATTTTTG CTGGCACAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC022501 unedited GCTCAGGTTTNGTAAACGACTTCGCTATAGGCGGCCGCACAACTTCGTATAGCATACATT ATACGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGAGTGAG AGGGAGGGAGCGCCGGCCGCGGGAGCGGGATGGAAACCAGCAGCCCGCGGCCCCCGCGGC CCAGCTCCAACCCGGGGCTGAGCCTGGACGCCCGGTTGGGCGTGGACACTCGCCTCTGGG CCAAGGTGCTGTTCACCGCGCTCTACGCACTCATCTGGGCGCTGGGCGCGGCGGGCAATG CGCTGTCCGTGCACGTGGTGCTGAAGGCGCGGGCCGGGCGAGCGGGGCGCCTGCGCCACC ACGTGCTCAGCCTGGCGCTCGCGGGCCTGCTGCTGCTGCTGGTCGGCGTGCCGGTGGAGC TCTACAGCTTCGTGTGGTTCCACTACCCCTGGGTCTTCGGCGACCTGGGCTGCCGCGGCT ACTACTTCGTGCACGAGCTGTGCGCCTACGCCACGGTGCTGAGCGTGGCAGGCCTGAGCG CCGAGCGCTGCCTAGCCGTGTGCCAGCCCCTGCGTGCCCGCAGCCTGCTGACGCCACGCC GGACCCGGTGGCTGGTGGCGCTCTCGTGGGCCGCCTCGCTCGGCCTCGCCATGCCCATGG GCCGTCATCATGGGGCAGAAGCACGAACTCGAGACGGCGGACGGGGAGCCGGAGCCCGCC TCGCGAGTGTGCACGGTGCTGGTGAGCCGCACCGCGCTTCAAGTCTNTATCCCAGTGAAT GTGCTAGTGGTCTTCGTGCTCCCCTGGGACTAACTGGCTTTCTTGAAGGGGGACCAGGAG CCACCTGGTGGGCCTCTGTTCCAAGGGCCGGCCCTTTTTACCCCGGGGATTCCCCCCCCA GCCGCCTGAGCTGCTGATGAAGGAG
Restriction Sites	Please inquire
ACCN	BC022501
Insert Size	1583 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC022501.1, AAH22501.1
RefSeq Size	1583 bp
RefSeq ORF	1230 bp
Locus ID	23620
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction
Gene Summary	The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

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