COP (CARD16) (BC033638) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	COP; COP1; PSEUDO-ICE
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC033638 edited GAGAAAAGCCATGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCATTCCAT GGGTGAAGGTACAATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCTGAACCA GGAAGAGATGGAGAAAGTAAAACGTGAAAATGCTACAGTTATGGATAAGACCCGAGCTTT GATTGACTCCGTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCATCACATACATTTG TGAAGAAGACAGTTACCTGGCAGAGACGCTGGGACTCTCAGCAGGTAAGGGTCAGTGACT CACACTCAAGTTCACCTAGGGCCTGTCTTCGTGCCTAACATTTGATTTCTTTACTAGTCA TGTTAATCTGCAGAATATCTTCTTATCTCTGCCTTTGGGCCATATTTCTGTAGCAGAGGC CCTATTGCATGTCCCTTGACTCTTTTTGTGTTCCTTCATCCTCAGTGCCCTCTTCTGATT AAAGTTCATTTTCTGTTCTGAGTACATGGTAGCTAATTTCCTTAAGGTCATGAGAACTAT CTAGAAAGCTTCATACAATATGTTCCAGTGTTCCTGGCAAGGCACGATATTTATTGATTG ATTTATTATTTTGTGTCCAGGGTGTCCCTAATCCCTTATGTAGTTGTTTGACATGAGCTT TAGGGTCTGTATTCAAATACTTTTTATAAATTCTTTTCAAACTTTTGCCCTCAGAGAAGA ATAAAGTATATTTAAGTGACGATGATACGTTCAGGAAATACATTCAATGATTACAGAATA GTAAAGATTTCAACAGGGCTCTTTCCTCCCGTTGCCCCCATGCATTTTCTTTTGAGTAAG ATCTGCTTGTCTGTTGCCAAGCTGCAGATCATACTGGGAGGCCTGGACTTCCATCATCTG CAGCCCTCCTAGGGCCTGATACAGTGCTCAGGAAATGAGCTTGCCCATTCTTATAATCCC TTGAACCTACAGCATGGTGAGGATGGGAGTTTTGGTGCACTTGAACATTATTTATTGTCA TTTAGTCAGGGTTGTGGGAGGAATTTGCAGTGAGGAGTGGCTTATGCATTGCTGTAAAGT TTTCCAGAGATGATAAGTGGCTATTTCAATGTTCTTCATCTTTTTATAGGTCCGATACCT GGAAATTAGCTTAGTACACAAGACTCCCAATTACTATTTTCTTCCTTCCCAGGTAATGTT GTTTTTCAATGAAGAGCATTCTTTGAACCCCATCTTCTTTAACATTAATTTAGTGGAATG AGCTCTGCTTGAAGGGGCTATGGAGAATTCCCATAGACTGATCATATAATTTTCTTTTTT AATCTATTCTGTTTTTGCAGAAACTGTTCCCAAAGCTTTACTACTCTTATTTATACTAAC AAAATCTGAATTTGTATCTCAAATTCTGATTACCCAAATAAGTACCAAACTTCATCATTT AAGACTACTGAAATATTCCCTCACATCTTCCAGAGACACATTTATGTAAACAATTTCAGA GCTGAACATGCCATTCTTCCCCACCCTGCTTCTCTTACAGTTTTGTGTAACTTGGTTTTT GATGCCACCATCACCAGTTGTTCAATCCAGGAACTTGAAACTCATCTTGGCCCCCTTCCT CTCATGCACCTCCAATATTCAAGCCATGGCCAAGTTTTATGCATTCTTCTCTCAAATTTG GAAATGTCTCTTCATTCTTACTTCTATTATTTTATTAAAGAACTCTTATTCCTTAAGTGC CCCCCTTAAAATAAAAGAAACTTATATTTGAAAGCAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC033638 unedited NGGTTCAAATTTGTATACGACTCATATAGGCGGCCGCGNATTCAGATCTGGTACCGGTCC GGAATTCCCGGGATGAGAAAGCCTGGCCGACAAGGTCCTGAAGGAGAAGAGAAAGCTGTT TATCCATTCCATGGGTGAAGGTACAATAAATGGCTTACTGGATGAATTATTACAGACAAG GGTGCTGAACCAGGAAGAGATGGAGAAAGTAAAACGTGAAAATGCTACAGTTATGGATAA GACCCGAGCTTTGATTGACTCCGTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCAT CACATACATTTGTGAAGAAGACAGTTACCTGGCAGAGACGCTGGGACTCTCAGCAGGTAA GGGTCAGTGACTCACACTCAAGTTCACCTAGGGCCTGTCTTCGTGCCTAACATTTGATTT CTTTACTAGTCATGTTAATCTGCAGAATATCTTCTTATCTCTGCCTTTGGGCCATATTTC TGTAGCAGAGGCCCTATTGCATGTCCCTTGACTCTTTTTGTGTTCCTTCATCCTCAGTGC CCTCTTCTGATTAAAGTTCATTTTCTGTTCTGAGTACATGGTAGCTAATTTCCTTAAGGT CATGAGAACTATCTAGAAAGCTTCATACAATATGTTCCAGTGTTCCTGGCAAGGCACGAT ATTTATTGATTGATTTATTATTTTGTGTCCAGGGTGTCCCTAATCCCTTATGTAGTTGTT TGACATGAGCNTTTAGGTCTGTATTCAAATACTTTTTATAAATTCTTTTCANACTTTTGC CCTCAGAGAAGATAAAGTATATTTAAGTGACGATGATACGTTCAGGAAAATACATTCATG ATTACAGAATAGTAAAGATTTTCACAGGGCTCTTTNCTNCCGTTGCCCCATGCATTTCTT TTGAGTAAGACTGCCTGCCTGTC
Restriction Sites	Please inquire
ACCN	BC033638
Insert Size	1830 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC033638.1, AAH33638.1
RefSeq Size	1830 bp
Locus ID	114769
Gene Summary	Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.[UniProtKB/Swiss-Prot Function]

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