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Cytochrome P450 3A5 (CYP3A5) (NM_000777) Human Untagged Clone
CAT＃: SC120801
CYP3A5 (untagged)-Human cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), transcript variant 1
CNY 5,616.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CP35; CYPIIIA5; P450PCN3; PCN3 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC120801 sequence for NM_000777 edited (data generated by NextGen Sequencing)
ATGGACCTCATCCCAAATTTGGCGGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG CTCCTCTATCTATATGGGACCCGTACACATGGACTTTTTAAGAGACTGGGAATTCCAGGG CCCACACCTCTGCCTTTGTTGGGAAATGTTTTGTCCTATCGTCAGGGTCTCTGGAAATTT GACACAGAGTGCTATAAAAAGTATGGAAAAATGTGGGGAACGTATGAAGGTCAACTCCCT GTGCTGGCCATCACAGATCCCGACGTGATCAGAACAGTGCTAGTGAAAGAATGTTATTCT GTCTTCACAAATCGAAGGTCTTTAGGCCCAGTGGGATTTATGAAAAGTGCCATCTCTTTA GCTGAGGATGAAGAATGGAAGAGAATACGGTCATTGCTGTCTCCAACCTTCACCAGCGGA AAACTCAAGGAGATGTTCCCCATCATTGCCCAGTATGGAGATGTATTGGTGAGAAACTTG AGGCGGGAAGCAGAGAAAGGCAAGCCTGTCACCTTGAAAGACATCTTTGGGGCCTACAGC ATGGATGTGATTACTGGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA GACCCCTTTGTGGAGAGCACTAAGAAGTTCCTAAAATTTGGTTTCTTAGATCCATTATTT CTCTCAATAATACTCTTTCCATTCCTTACCCCAGTTTTTGAAGCATTAAATGTCTCTCTG TTTCCAAAAGATACCATAAATTTTTTAAGTAAATCTGTAAACAGAATGAAGAAAAGTCGC CTCAACGACAAACAAAAGCACCGACTAGATTTCCTTCAGCTGATGATTGACTCCCAGAAT TCGAAAGAAACTGAGTCCCACAAAGCTCTGTCTGATCTGGAGCTCGCAGCCCAGTCAATA ATCTTCATTTTTGCTGGCTATGAAACCACCAGCAGTGTTCTTTCCTTCACTTTATATGAA CTGGCCACTCACCCTGATGTCCAGCAGAAACTGCAAAAGGAGATTGATGCAGTTTTGCCC AATAAGGCACCACCTACCTATGATGCCGTGGTACAGATGGAGTACCTTGACATGGTGGTG AATGAAACACTCAGATTATTCCCAGTTGCTATTAGACTTGAGAGGACTTGCAAGAAAGAT GTTGAAATCAATGGGGTATTCATTCCCAAAGGGTCAATGGTGGTGATTCCAACTTATGCT CTTCACCATGACCCAAAGTACTGGACAGAGCCTGAGGAGTTCCGCCCTGAAAGGTTCAGT AAGAAGAAGGACAGCATAGATCCTTACATATACACACCCTTTGGAACTGGACCCAGAAAC TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCTTGAAATTAGACACGCAAGGA CTTCTTCAACCAGAAAAACCCATTGTTCTAAAGGTGGATTCAAGAGATGGAACCCTAAGT GGAGAATGA Clone variation with respect to NM_000777.3 >OriGene 5' read for NM_000777 unedited
NGGGTCAGGATTTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGGGAAGC TCCAGGCAAACAGCCCAGCAAACAGCAGCACTCAGCTAAAAGGAAGACTCACAGAACACA GTTGAAGAAGGAAAGTGGCGATGGACCTCATCCCAAATTTGGCGGTGGAAACCTGGCTTC TCCTGGCTGTCAGCCTGGTGCTCCTCTATCTATATGGGACCCGTACACATGGACTTTTTA AGAGACTGGGAATTCCAGGGCCCACACCTCTGCCTTTGTTGGGAAATGTTTTGTCCTATC GTCAGGGTCTCTGGAAATTTGACACAGAGTGCTATAAAAAGTATGGAAAAATGTGGGGAA CGTATGAAGGTCAACTCCCTGTGCTGGCCATCACAGATCCCGACGTGATCAGAACAGTGC TAGTGAAAGAATGTTATTCTGTCTTCACAAATCGAAGGTCTTTAGGCCCAGTGGGATTTA TGAAAAGTGCCATCTCTTTAGCTGAGGATGAAGAATGGAAGAGAATACGGTCATTGCTGT CTCCAACCTTCACCAGCGGAAAACTCAAGGAGATGTTCCCCATCATTGCCCAGTATGGAG ATGTATTGGTGAGAAACTTGAGGCGGGAAGCAGAGAAAGGCAAGCCTGTCACCTTGAAAG ACATCTTTGGGGCCTACAGCATGGATGTGATTACTGGCACATCATTTGGAGTGAACATCG ACTCTCTCAACAATCCACAAGACCCCTTTGTGGAGAGCACTAAGAAGTTCCTAANATTTG GTTTCTTAGATCCATTATTTCTCTCAATATACTCTNTCCATTCCTTACCCCAGTNTTTGA GCATTAATGTCTCTCTGTTTCCAAAGATACATANATTTTTTAAGTAATCTGTAACAGAAT GAAGAAAGN >OriGene 3' read for NM_000777 unedited
CCTTGTTAGGCCCTCTTTTTTCAGGTTTTATTGACTAAGTTGAAATCTCTGGTGTTCTGG GGCACAGCTTTCTTGAAGACCAAAGTAGAAGTCCTTAGAATAACTCATTCTCCACTTAGG GTTCCATCTCTTGAATCCACCTTTAGAACAATGGGTTTTTCTGGTTGAAGAAGTCCTTGC GTGTCTAATTTCAAGGGGATCTGTGTTTCTTTACAAGGTTTGAAGGAGAAGTTCTGAAGG ACTCTGATTAGAGCAAGTTTCATGTTCATGAGAGCAAACCTCATGCCAATGCAGTTTCTG GGTCCAGTTCCAAAGGGTGTGTATATGTAAGGATCTATGCTGTCCTTCTTCTTACTGAAC CTTTCAGGGCGGAACTCCTCAGGCTCTGTCCAGTACTTTGGGTCATGGTGAAGAGCATAA GTTGGAATCACCACCATTGACCCTTTGGGAATGAATACCCCATTGATTTCAACATCTTTC TTGCAAGTCCTCTCAAGTCTAATAGCAACTGGGAATAATCTGAGTGTTTCATTCACCACC ATGTCAAGGTACTCCATCTGTACCACGGCATCATAGGTAGGTGGTGCCTTATTGGGCAAA ACTGCATCAATCTCCTTTTGCAGTTTCTGCTGGACATCAGGGTGAGTGGCCAGTTCATAT AAAGTGAAGGAAAGAACACTGCTGGTGGTTTCATAGCCAGCAAAAATGAAGATTATTGAC TGNGCTGCGAGCTCCAGATCAGACAGAGCTTTGTGGGACTCAGTTTCTTTCGAATTCTGG GAGTCAATCATCAGCTGAAGGAAATCTAGTCGGTGCTTTTGTTTGTCGTTGAGGCGACTT TTCTTCATTCTGTTTACANGATTACTTAAAAATTTATGGTATCTTTTGGAACAGAGAGAC ATTAATGCTTCANAACTGNNGTA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000777 |
| Insert Size | 1800 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_000777.2, NP_000768.1 |
| RefSeq Size | 1707 bp |
| RefSeq ORF | 1509 bp |
| Locus ID | 1577 |
| UniProt ID | P20815 |
| Domains | p450 |
| Protein Families | Druggable Genome, P450, Transmembrane |
| Protein Pathways | Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] Transcript Variant: This variant (1) encodes the longest isoform (1). |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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A Naturally Occurring Isoform-Specific Probe for Highly Selective and Sensitive Detection of Human Cytochrome P450 3A5
,Wu, JJ;Cao, YF;Feng, L;He, YQ;Hong, JY;Dou, TY;Wang, P;Hao, DC;Ge, GB;Yang, L;,
J. Med. Chem.
,PubMed ID 28441491
[CYP3A5]
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Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc
,Yanhui Lu, Craig W. Hendrix, and Namandjé N. Bumpus,
Drug Metab. Dispos., Dec 2012; 40: 2221 - 2230.
[CYP3A5]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207432 | CYP3A5 (Myc-DDK-tagged)-Human cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), transcript variant 1 |
CNY 5,608.00 |
|
| RC207432L1 | Lenti ORF clone of Human cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), transcript variant 1, Myc-DDK-tagged |
CNY 8,008.00 |
|
| RC207432L2 | Lenti ORF clone of Human cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), transcript variant 1, mGFP tagged |
CNY 6,460.00 |
|
| RC207432L3 | Lenti ORF clone of Human cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), transcript variant 1, Myc-DDK-tagged |
CNY 8,008.00 |
|
| RC207432L4 | Lenti ORF clone of Human cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), transcript variant 1, mGFP tagged |
CNY 8,008.00 |
|
| RG207432 | CYP3A5 (tGFP-tagged) - Human cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), transcript variant 1 |
CNY 7,208.00 |
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